Effect of sodium triphosphate on particle size of heat‐induced whey protein concentrate aggregates

Liu, Diru; Cheng, Jianjun; Zhao, Changhui; Guo, Mingruo

doi:10.1002/fsn3.665

Cited by 4 publications

(3 citation statements)

References 41 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PWPC-GSH system was prepared with advantages of simplicity, mildness, and organic solvent-free in comparison with other carriers based on poly isobutylcyanoacrylate [ 30 ], Eudragit RS 100/cyclodextrin [ 31 ] and montmorillonite [ 32 ]. As shown in Figure 1 A, PWPC exhibited bimodal pattern with two peaks at 594 nm and 4580 nm with a wide particle size distribution (span of 9.22), consistent with previous research [ 33 ]. Combination with GSH (287.83 ± 6.18 nm) slightly increased particle size (D 50 ) from 1085 ± 35.35 to 1115 ± 7.07 nm with decreased span from 9.22 ± 0.22 to 6.86 ± 0.19.…”

Section: Resultssupporting

confidence: 91%

Polymerized Whey Protein Concentrate-Based Glutathione Delivery System: Physicochemical Characterization, Bioavailability and Sub-Chronic Toxicity Evaluation

et al. 2021

Self Cite

View full text Add to dashboard Cite

Glutathione (GSH) is a powerful antioxidant, but its application is limited due to poor storage stability and low bioavailability. A novel nutrient encapsulation and delivery system, consisting of polymerized whey protein concentrate and GSH, was prepared and in vivo bioavailability, antioxidant capacity and toxicity were evaluated. Polymerized whey protein concentrate encapsulated GSH (PWPC-GSH) showed a diameter of roughly 1115 ± 7.07 nm (D50) and zeta potential of 30.37 ± 0.75 mV. Differential scanning calorimetry (DSC) confirmed that GSH was successfully dispersed in PWPC particles. In vivo pharmacokinetics study suggested that PWPC-GSH displayed 2.5-times and 2.6-fold enhancement in maximum concentration (Cmax) and area under the concentration–time curve (AUC) as compared to free GSH. Additionally, compared with plasma of mice gavage with free GSH, significantly increased antioxidant capacity of plasma in mice with PWPC-GSH was observed (p < 0.05). Sub-chronic toxicity evaluation indicated that no adverse toxicological reactions related to oral administration of PWPC-GSH were observed on male and female rats with a diet containing PWPC-GSH up to 4% (w/w). Data indicated that PWPC may be an effective carrier for GSH to improve bioavailability and antioxidant capacity.

show abstract

Section: Resultssupporting

confidence: 91%

Polymerized Whey Protein Concentrate-Based Glutathione Delivery System: Physicochemical Characterization, Bioavailability and Sub-Chronic Toxicity Evaluation

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The crosslinker TPP is generally recognized as safe and permitted to use as a food additive by the U.S. Food and Drug Administration [39].…”

Section: Main Textmentioning

confidence: 99%

Degradability of chitosan micro/nanoparticles for pulmonary drug delivery

Islam

Dmour

Taha

2019

Heliyon

203

View full text Add to dashboard Cite

Chitosan, a natural carbohydrate polymer, has long been investigated for drug delivery and medical applications due to its biodegradability, biocompatibility and low toxicity. The micro/nanoparticulate forms of chitosan are reported to enhance the efficiency of drug delivery with better physicochemical properties including improved solubility and bioavailability. This polymer is known to be biodegradable and biocompatible; however, crosslinked chitosan particles may not be biodegradable. Crosslinkers (e.g., tripolyphosphate and glutaraldehyde) are needed for efficient micro/nanoparticle formation, but it is not clear whether the resultant particles are biodegradable or able to release the encapsulated drug fully. To date, no studies have conclusively demonstrated the complete biodegradation or elimination of chitosan nanoparticles in vivo . Herein we review the synthesis and degradation mechanisms of chitosan micro/nanoparticles frequently used in drug delivery especially in pulmonary drug delivery to understand whether these nanoparticles are biodegradable.

show abstract

“…The heat treatment can denature bovine milk serum proteins, which then leads to a decrease in milk serum protein concentration and a weakening of the intensity of the major milk serum protein bands in bovine milk such as α‐lactalbumin and β‐lactoglobulin (Qian et al., 2017). Furthermore, when milk serum proteins were heat‐denatured, the sulfhydryl groups and disulfide bonds contained inside its molecules would be exposed, and protein aggregates could be formed through the exchange of sulfhydryl–disulfide bonds (Liu et al., 2018). Although these protein aggregates exist in the soluble state in bovine milk, a part of them was removed during high‐speed centrifugation, which leads to a decrease in milk serum protein concentration and a weakened intensity of the α‐lactalbumin and β‐lactoglobulin bands (Corredig & Dalgleish, 1996, 1999).…”

Section: Resultsmentioning

confidence: 99%

Investigating changes of proteome in the bovine milk serum after retort processing using proteomics techniques

Wei

Kang

Liao

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

The objective of this study was to investigate the changes of the proteins in bovine milk serum after retort processing by label‐free quantification proteomics techniques. A total of 96 and 106 proteins were quantified in control group (CG) and retort group (RG), respectively. Hierarchical clustering analysis of the identified milk serum proteins showed a decrease in the abundance of most proteins, such as serum albumin, lactoperoxidase, lactotransferrin, and complement C3, and an increase in the abundance of other proteins such as κ‐casein, lipocalin 2, and Perilipin. Student's t‐test showed 21 proteins significantly differential abundance between CG and RG (p < .05), of which intensity‐based absolute quantification (iBAQ) of five proteins decreased and iBAQ of 16 proteins increased. Bioinformatics analysis demonstrated that retort processing increased the digestibility of proteins, but this improvement was offset by a decrease in the digestibility of proteins caused by protein modification. Our results provide insight into the proteome of retort sterilized milk for the first time. Given the extremely high security of retort sterilized milk, the proteome of bovine milk serum changes after retort sterilization exposed in this study will contribute to the formula design of retort sterilized milk products.

show abstract

Effect of sodium triphosphate on particle size of heat‐induced whey protein concentrate aggregates

Cited by 4 publications

References 41 publications

Polymerized Whey Protein Concentrate-Based Glutathione Delivery System: Physicochemical Characterization, Bioavailability and Sub-Chronic Toxicity Evaluation

Polymerized Whey Protein Concentrate-Based Glutathione Delivery System: Physicochemical Characterization, Bioavailability and Sub-Chronic Toxicity Evaluation

Degradability of chitosan micro/nanoparticles for pulmonary drug delivery

Investigating changes of proteome in the bovine milk serum after retort processing using proteomics techniques

Contact Info

Product

Resources

About