Effect of Sodium Salicylate on the Viscoelastic Properties and Stability of Polyacrylate-Based Hydrogels for Medical Applications

Abstract

Investigation was made into the effect exerted by the presence of sodium salicylate (0–2 wt.%), in Carbomer-based hydrogel systems, on processing conditions, rheological and antimicrobial properties in tests against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacterial strains, and examples of yeast (Candida albicans) and mould (Aspergillus niger). In addition, the work presents an examination of long-term stability by means of aging over one year the given hydrogels at 8°C and 25°C. The results show that 0.5 wt.% NaSal demonstrated a noticeable effect on the hydrogel neutralization process, viscosity, and antimicrobial properties against all of the tested microorganisms. The long-term stability studies revealed that hydrogels can maintain antimicrobial activity as well as viscosity to a degree that would be sufficient for practical use.

An ionic hydrogel with stimuli-responsive, self-healable and injectable characteristics for the targeted and sustained delivery of doxorubicin in the treatment of breast cancer

“…22 Raskova presented the effect exerted by the presence of NaSal in Carbomer-based hydrogel systems, which shows antimicrobial properties against Gram-positive, Gram-negative bacterial strains, yeast and mould. 23 Combining different ionic functionalization to the judiciously composed structural architecture of the IL can specifically exploit the advantages of both, IL and solid polymer structures, enhancing the mechanical stability, improved processability and durability of the hydrogels. 12 Bearing in mind all abovedescribed considerations and in the framework of our interest in obtaining supramolecular gels from IL, herein we synthesized active pharmaceutical ingredient based IL, i.e.1-methyl-3-hexadecylimidazolium salicylate (C 16 MeImSal) as the LMWG.…”

Effect of polyethylene glycol plasticizer on long‐term antibacterial activity and the release profile of bacteriocin nisin from polylactide blends

“…Indeed, other “added value” functionality is needed in order to increase their competitiveness on the market. An example of such added value in packaging materials is enhancement with antibacterial activity, a desirable property to the packaging, textile, automotive, and medical sectors, among others …”

Recombinant Humanized Collagen Type XVII Promotes Oral Ulcer Healing via Anti-Inflammation and Accelerate Tissue Healing

“…Carbomer viscosity is affected by soluble ions. 29 The presence of soluble ions in saliva will reduce its viscosity. The solubility of rhCol 17 in carbomer is greatly affected by PH.…”