Effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone and pranoprofen eye drops in the treatment of dry eye after phacoemulsification

Abstract

Purpose: To investigate the clinical effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone, and pranoprofen eye drops in the treatment of dry eye after phacoemulsification. Methods: Medical records of 188 patients with dry eye after phacoemulsification, treated in our hospital from August 2020 to August 2021, were included and divided into groups based on the type of dry eye treatment. Patients in the control group ( n = 90) were treated with tobramycin, dexamethasone, and pranoprofen eye drops. Patients in the test group ( n = 98) were treated with sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops. The tear secretion test (TST), film rupture time (BUT), corneal fluorescence staining (FS) score, levels of interleukin (IL)-6, and tumor necrosis factor (TNF)-α before the treatment and at 1 month follow-up, the overall total effective rate and the number of completely cured cases were compared between the two groups. Multiple linear regression was used to calculate coefficients for predicting clinical variables. Ordinal logistic regression was used to compute coefficients and odds ratios for predicting effective scores. Results: The total effective rate in the observation group (99%) was significantly higher than that in the control group (80.00%). After the treatment, the TST and BUT indexes of the observation group were higher compared to the control group, and the FS score of the observation group was lower than that of the control group. TNF-α and IL-6 levels of the observation group were lower compared to the control group. Logistic regression analysis demonstrated that the differences in the effective rate and clinical variables between the two groups remained significant after adjusting for the effect of age. Conclusion: A combination of sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops for the treatment of dry eye after phacoemulsification can improve the curative effect, reduce corneal fluorescein staining and inflammatory factor index levels compared to the treatment regimen lacking sodium hyaluronate eye drops.

Efficacy of adding sodium hyaluronate eye drops to tobramycin and dexamethasone in the treatment of post- cataract surgery dry eye disease: A Retrospective Analysis and Prospective Questionnaire Assessment

“…Similar ndings were reported in the few earlier studies that assessed the bene t of adding sodium hyaluronate to the treatment regimen of DED after cataract surgery. 13,15,22 Chen et al 13 observed that sodium hyaluronate was able to restore the structure of the tear lm and improve the regularity of the corneal surface. In agreement with our study, Lu et al 15 found that combining sodium hyaluronate with pranoprofen, tobramycin, and dexamethasone improved the curative effect compared to when sodium hyaluronate was lacking.…”

“…13,15,22 Chen et al 13 observed that sodium hyaluronate was able to restore the structure of the tear lm and improve the regularity of the corneal surface. In agreement with our study, Lu et al 15 found that combining sodium hyaluronate with pranoprofen, tobramycin, and dexamethasone improved the curative effect compared to when sodium hyaluronate was lacking. Yang and Wang 22 reported that sodium hyaluronate combined with pranoprofen had effectively treated DED and was able to enhance tear secretion, keep ocular moisture, recover tear lm stability, and improve the patients' quality of life.…”

“…Based on a published similar study, 15 which reported that adding sodium hyaluronate increased the e cacy scores from 88.9-99%, and using an α level of 0.05 and a power of 80%, a minimum of 68 patients were required in each group.…”

Efficacy of Adding Sodium Hyaluronate Eye Drops to Tobramycin and Dexamethasone in the Treatment of Post-Cataract Surgery Dry Eye Disease: A Retrospective Analysis and Prospective Questionnaire Assessment

“…The calculation was conducted using the formula for comparing two independent proportions. Specifically, we used the formula based on the Z-test for proportions, taking into account the reported efficacy scores from a similar published study, 19 which found that adding sodium hyaluronate increased the efficacy scores from 88.9% to 99%. The minimum number of participants required in each group to achieve a statistically significant result with a confidence level of 95% (α level of 0.05) and a power of 80% was 68 patients in each group.…”