Abstract:Despite the great impairment in water balance occurring in the Brattleboro rat, homozygous for diabetes insipidus and lacking hypothalamic arginine-vasopressin, fed a normal sodium diet, the metabolic effects of a chronic sodium deprivation were similar in the Brattleboro rat and in the Long-Evans rat used as control. Concomitantly, whilst the plasma and adrenal concentrations of aldosterone were two fold lower in the Brattleboro rat than in the Long-Evans rat fed a normal diet, after ten days of sodium restri… Show more
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