Effect of SOCS1 overexpression on RPE cell activation by proinflammatory cytokines

Bazewicz, M; Draganova, Dafina; Makhoul, Maya; Chtarto, Abdelwahed; Elmaleh, Valerie; Tenenbaum, Liliane; Caspers, Laure; Bruyns, Catherine; Willermain, François

doi:10.1016/j.neulet.2016.07.054

Cited by 2 publications

(1 citation statement)

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“…The differential expression of SOCS1 has been observed in corneal cells of myopic patients 30 and SOCS1 deficient mice develop severe eye diseases 31 . In RPE cells, SOCS1 higher expression inhibits IFNγ-mediated responses which leads to uveitis 32 . GRB2 was found to be upregulated in chicks during imposed myopic defocus 33 and also during retinal stress and neovascularization 34 .…”

Section: Discussionmentioning

confidence: 99%

Epigenetically dysregulated genes and pathways implicated in the pathogenesis of non-syndromic high myopia

Vishweswaraiah

Swierkowska

Ratnamala

et al. 2019

Sci Rep

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Myopia, commonly referred to as nearsightedness, is one of the most common causes of visual disability throughout the world. It affects more people worldwide than any other chronic visual impairment condition. Although the prevalence varies among various ethnic groups, the incidence of myopia is increasing in all populations across globe. Thus, it is considered a pressing public health problem. Both genetics and environment play a role in development of myopia. To elucidate the epigenetic mechanism(s) underlying the pathophysiology of high-myopia, we conducted methylation profiling in 18 cases and 18 matched controls (aged 4–12 years), using Illumina MethylationEPIC BeadChips array. The degree of myopia was variable among subjects, ranging from −6 to −15D. We identified 1541 hypermethylated CpGs, representing 1745 genes (2.0-fold or higher) (false discovery rate (FDR) p ≤ 0.05), multiple CpGs were p < 5 × 10−8 with a receiver operating characteristic area under the curve (ROC-AUC) ≥ 0.75 in high-myopia subjects compared to controls. Among these, 48 CpGs had excellent correlation (AUC ≥ 0.90). Herein, we present the first genome-wide DNA methylation analysis in a unique high-myopia cohort, showing extensive and discrete methylation changes relative to controls. The genes we identified hold significant potential as targets for novel therapeutic intervention either alone, or in combination.

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Section: Discussionmentioning

confidence: 99%