Effect of soccer heading ball speed on S100B, sideline concussion assessments and head impact kinematics

Dorminy, Millie; Hoogeveen, Ashley; Tierney, Ryan; Higgins, Michael J.; McDevitt, Jane; Kretzschmar, Jan

doi:10.3109/02699052.2015.1035324

Cited by 44 publications

(46 citation statements)

References 39 publications

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“…Moreover, Dorminy et al examined the effects of soccer ball heading on blood levels of S100β. In this study, approximately 16 collegiate soccer players were asked to complete 5 soccer ball headers at 25, 35 or 45 miles per hour (Dorminy et al, 2015). Results showed no differences in blood levels of S100β either before or immediately after headers, regardless of ball velocity.…”

Section: Serological Biomarkers For Brain Injurymentioning

confidence: 99%

Blood biomarkers for brain injury: What are we measuring?

Kawata

Liu

Merkel

et al. 2016

Neuroscience & Biobehavioral Reviews

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187

168

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Accurate diagnosis for mild traumatic brain injury (mTBI) remains challenging, as prognosis and return-to-play/work decisions are based largely on patient reports. Numerous investigations have identified and characterized cellular factors in the blood as potential biomarkers for TBI, in the hope that these factors may be used to gauge the severity of brain injury. None of these potential biomarkers have advanced to use in the clinical setting. Some of the most extensively studied blood biomarkers for TBI include S100β, neuron-specific enolase, glial fibrillary acidic protein, and Tau. Understanding the biological function of each of these factors may be imperative to achieve progress in the field. We address the basic question: what are we measuring? This review will discuss blood biomarkers in terms of cellular origin, normal and pathological function, and possible reasons for increased blood levels. Considerations in the selection, evaluation, and validation of potential biomarkers will also be addressed, along with mechanisms that allow brain-derived proteins to enter the bloodstream after TBI. Lastly, we will highlight perspectives and implications for repetitive neurotrauma in the field of blood biomarkers for brain injury.

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Section: Serological Biomarkers For Brain Injurymentioning

confidence: 99%

Blood biomarkers for brain injury: What are we measuring?

Kawata

Liu

Merkel

et al. 2016

Neuroscience & Biobehavioral Reviews

Self Cite

187

168

View full text Add to dashboard Cite

show abstract

“…Beginning in the 21st century, S100B has been under investigation as a serum biomarker of mild traumatic brain injury in sport, specifically as an indicator of sport‐related concussion and subconcussion injury . Although serum S100B concentration ([S100B]) has been shown to increase in response to the number of contacts an athlete experiences, [S100B] has also been shown to rise in relation to exercise alone .…”

Section: Introductionmentioning

confidence: 99%

Response of protein S100B to playing American football, lifting weights, and treadmill running

Rogatzki

Keuler

Harris

et al. 2018

Scandinavian Med Sci Sports

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“…32, 33 Several studies have found increased serum levels of S100β in the absence of head injury in soccer players and marathon runners, and individuals participating in vigorous exercise. 19, 28, 34, 35 …”

Section: Biofluid Biomarkers Of Astroglial Injurymentioning

confidence: 99%

“…34, 35, 44–47 In the article by Otto et al twelve soccer players performed twenty controlled headers and showed no rise in S100β protein levels. Similarly, controlled headers in studies by Mussack and Zetterberg, produced insignificant elevations in S100β.…”

Section: Biofluid Biomarkers Of Astroglial Injurymentioning

confidence: 99%

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Potential Blood-based Biomarkers for Concussion

Papa

2016

Sports Medicine and Arthroscopy Review

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Mounting research in the field of sports concussion biomarkers has led to a greater understanding of the effects of brain injury from sports. A recent systematic review of clinical studies examining biomarkers of brain injury following sports-related concussion established that almost all studies have been published either in or after the year 2000. In an effort to prevent CTE and long-term consequences of concussion, early diagnostic and prognostic tools are becoming increasingly important; particularly in sports and in military personnel, where concussions are common occurrences. Early and tailored management of athletes following a concussion with biomarkers could provide them with the best opportunity to avoid further injury. Should blood-based biomarkers for concussion be validated and become widely available, they could have many roles. For instance, a point-of-care test could be used on the field by trained sport medicine professionals to help detect a concussion. In the clinic or hospital setting, it could be used by clinicians to determine the severity of concussion and be used to screen players for neuroimaging (CT and/or MRI) and further neuropsychological testing. Furthermore, biomarkers could have a role in monitoring progression of injury and recovery and in managing patients at high risk of repeated injury by being incorporated into guidelines for return to duty, work or sports activities. There may even be a role for biomarkers as surrogate measures of efficacy in the assessment of new treatments and therapies for concussion.

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Effect of soccer heading ball speed on S100B, sideline concussion assessments and head impact kinematics

Abstract: In this controlled setting, an acute bout of soccer heading across various ball velocities did not affect S100B or concussion assessment test scores. These findings are preliminary, as the small sample size in each group may have played a role in the lack of significant findings.

Cited by 44 publications

References 39 publications

Blood biomarkers for brain injury: What are we measuring?

Blood biomarkers for brain injury: What are we measuring?

Response of protein S100B to playing American football, lifting weights, and treadmill running

Potential Blood-based Biomarkers for Concussion

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