Effect of smoking on single dose pharmacokinetics of phenobarbital

A Mechanistic Physiologically Based Pharmacokinetic-Enzyme Turnover Model Involving both Intestine and Liver to Predict CYP3A Induction-Mediated Drug–Drug Interactions

“…2a1, 2b1, and 2c1) were comparable with the reported data. The estimated C max and AUC from the predicted plasma concentration–time profiles following oral administration of the three individual inducers were 11.32 and 87.99 μg h/mL for rifampin, 1.74 and 122 μg h/mL for carbamazepine, and 1.31 and 216.23 μg h/mL for phenobarbital, respectively, which were in agreement with reported data (13.61 ± 3.96 and 79.79 ± 27.35 μg·h/mL for rifampin,48 1.72 ± 0.10 and 118 ± 36 μg·h/mL for carbamazepine,49 and 1.25 ± 0.10 and 295.55 ± 68.35 μg h/mL for phenobarbital50). The fold‐errors of C max and AUC between observed and predicted data were less than 1.5, indicating validity of the mechanistic PBPK‐enzyme turnover model in the simulation of three inducers.…”