“…Looking at the younger subgroup (20-29y), who had the lower 25(OH)D levels, we did not find any differences in the indices of bone remodeling between smokers and non-smokers, although smoking has been associated with reduced OPG production and increased bone remodeling, as shown by Lappin et al 33 In terms of the routine measurements of calcium, phosphate, ALP and PTH, studies have demonstrated that these parameters are not adequate to identify patients with hypovitaminosis D 7,32 and are thus not reliable predictors of hypovitaminosis D. 31 Studies of the relationship between vitamin D status and bone turnover have yielded conflicting results, 7,34-36 which may be attributed, at least in part, to differences in dietary calcium intake. Notably, several studies supported an inverse relationship between 25(OH)D and serum PTH (and consequently bone turnover markers as a result of secondary hyperparathyroidism) when dietary Ca intake is adequate; 37,38 it should be noted that in our study, the daily dietary calcium consumption was very low (on average 328mg/day).…”
“…Looking at the younger subgroup (20-29y), who had the lower 25(OH)D levels, we did not find any differences in the indices of bone remodeling between smokers and non-smokers, although smoking has been associated with reduced OPG production and increased bone remodeling, as shown by Lappin et al 33 In terms of the routine measurements of calcium, phosphate, ALP and PTH, studies have demonstrated that these parameters are not adequate to identify patients with hypovitaminosis D 7,32 and are thus not reliable predictors of hypovitaminosis D. 31 Studies of the relationship between vitamin D status and bone turnover have yielded conflicting results, 7,34-36 which may be attributed, at least in part, to differences in dietary calcium intake. Notably, several studies supported an inverse relationship between 25(OH)D and serum PTH (and consequently bone turnover markers as a result of secondary hyperparathyroidism) when dietary Ca intake is adequate; 37,38 it should be noted that in our study, the daily dietary calcium consumption was very low (on average 328mg/day).…”
“…Apatzidou et al (2005) stated that smokers with periodontal disease have a suppressed inflammatory response, a significantly less favourable clinical outcome and seem to have an altered host antibody response to antigenic challenge than non-smokers although; the subgingival microflora of smokers appears similar to that of non-smokers. Lappin et al (2007) reported decreased serum OPG levels and greater soluble receptor activator of nuclear-factor kappa B ligand (sRANKL) sRANKL/OPG ratios in smoker patients in the maintenance program than the non-smoker counterparts. Negative correlation between pack-years and total OPG amount in peri-implant crevicular fluid was detected in clinically healthy implants (Arıkan et al 2008).…”
“…Patients with diagnosed periodontitis have been reported to have an increase in RANKL and a decrease in OPG in both the gingival tissues and in gingival crevicular fluid. As a consequence, RANKL/OPG ratios are found to be increased in periodontitis patients when compared to healthy controls (Buduneli et al 2008;Lappin et al 2007;Tang et al 2009). …”
Section: Periodontitis In Smokersmentioning
confidence: 97%
“…Periodontitis is a chronic inflammatory disease that is caused by an infection of anaerobic, gram-negative bacteria (Buduneli et al 2008;Lappin et al 2007). The bacteria colonize in the subgingival area, and they cause localized and systemic elevations of pro-inflammatory cytokines (Buduneli et al 2008).…”
Section: Periodontitis In Smokersmentioning
confidence: 99%
“…The periodontal ligament fibroblasts appear to be involved in both stimulatory and inhibitory processes. However, gingival fibroblasts have been shown to produce higher levels of OPG and may have a greater protective effect than the periodontal ligament fibroblasts (Lappin et al 2007). Overall, bone resorption will occur in periodontitis as the result of the uncoupled process in bone remodeling, and it is usually reflected in an increased RANKL/OPG ratio.…”
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