Effect of smoking on macular function and retinal structure in retinitis pigmentosa

Oishi, Akio; Noda, Kazunori; Birtel, Johannes; Miyake, Masahiro; Sato, Akira; Hasegawa, Tomoko; Miyata, Manabu; Numa, Shogo; Issa, Peter Charbel; Tsujikawa, Akitaka

doi:10.1093/braincomms/fcaa117

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Interestingly, despite the similar duration of diagnosis before surgery and CDR, the smoker group also had a significantly lower mean BCVA. Because of the design and scope of our study, we cannot make a valid assumption as to the impact of tobacco smoking on the affectation of the central visual field due to glaucoma; however, smoking has been found to have a negative effect on visual acuity in patients with conditions such as retinitis pigmentosa and age-related macular degeneration, in which a possible cause has been postulated to be the chronic inflammation and oxidative stress resulting in cone cell death (20) .…”

Section: Figurementioning

confidence: 99%

Effect of tobacco smoking on outcomes of trabeculectomy

Acosta¹,

Gould²,

Rahman³

et al. 2022

ABO

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To evaluate the effect of tobacco smoking on trabeculectomy outcomes. Methods: Charts of patients with glaucoma who underwent trabeculectomy performed by a single surgeon between 2007 and 2016 were retrospectively reviewed. Charts were screened for a documented history of smoking status before surgery. Demographic and clinical preoperative variables were recorded. Based on smoking history, subjects were divided into two groups: smokers and nonsmokers. Any bleb-related interventions (e.g., 5-flourouracil injections ± laser suture lysis) or bleb revision performed during the postoperative period were noted. Success was defined as an intraocular pressure >5 mmHg and <21 mm Hg without (complete success) or with (qualified success) the use of ocular hypotensive medications. Failure was identified as a violation of the criteria mentioned above. Results: A total of 98 eyes from 83 subjects were included. The mean age of the subjects was 70.7 ± 11.09 years, and 53% (44/83) were female. The most common diagnosis was primary open-angle glaucoma in 47 cases (47.9%). The smokers Group included 30 eyes from 30 subjects. When compared with nonsmokers, smokers had a significantly worse preoperative best-corrected visual acuity (p=0.038), greater central corneal thickness (p=0.047), and higher preoperative intraocular pressure (p=0.011). The success rate of trabeculectomy surgery at 1 year was 56.7% in the smokers Group compared with 79.4% in the Group nonsmokers (p=0.020). Smoking presented an odds ratio for failure of 2.95 (95% confidence interval, 1.6-7.84). Conclusion: Smokers demonstrated a significantly lower success rate 1 year after trabeculectomy compared with nonsmokers and a higher requirement for bleb-related interventions.

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Section: Figurementioning

confidence: 99%

Effect of tobacco smoking on outcomes of trabeculectomy

Acosta¹,

Gould²,

Rahman³

et al. 2022

ABO

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“…However, its efficacy should be addressed in future studies. In addition, a study showed that smoking is detrimental to patients with RP, as it worsens macular function and structural integrity [32]. Hence, smoking may not benefit patients with RP.…”

Section: Rp: Intervention Strategy At An Early Stagementioning

confidence: 99%

Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A Review

Wang

Geng

et al. 2022

Oxidative Medicine and Cellular Longevity

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The retina, owing to its cellular anatomy and physical location, is susceptible to generating reactive oxygen species (ROS), which are associated with several major retinal diseases. When ROS exceeds the body’s natural antioxidants, the retina is in a state of oxidative stress, which is recognized as the pathogenesis of retinal diseases. The early stage of the pathogenic process is an adaptive change in which oxidative stress and endogenous defense mechanisms occur. If no treatment is applied, the retinal diseases will progress to the pathological stage with neuronal and vascular dysfunction or damage and even blindness. This review summarizes the role of oxidative stress in several common retinal diseases, including retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, glaucoma, and retinopathy of prematurity. In addition, we discuss the early intervention strategies for these diseases. An outline is provided to identify potential intervention targets for further research. Early intervention for retinal diseases is necessary and urgent and may offer hope to improve patients’ quality of life through functional vision.

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“…Immunomodulatory therapies, whether for tumour therapy (melanoma, basal cell carcinoma), rheumatological conditions or ophthalmic diseases, may not only have ocular side-effects, but may also point to systemic conditions associated with vision problems (e. g. vitamin A deficiency associated with ulcerative colitis). Dietary and lifestyle factors should also be considered: For example, there are indications of possible negative effects on the disease course when patients with variants in the ABCA4 gene take high-dose vitamin A, or when patients with retinitis pigmentosa smoke [19,20].…”

Section: Medical Historymentioning

confidence: 99%

Diagnosis of Inherited Retinal Diseases

Birtel

Yusuf

Priglinger

et al. 2021

Klin Monbl Augenheilkd

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Inherited retinal diseases are a frequent cause of severe visual impairment or blindness in children and adults of working age. Across this group of diseases, there is great variability in the degree of visual impairment, the impact on everyday life, disease progression, and the suitability to therapeutic intervention. Therefore, an early and precise diagnosis is crucial for patients and their families. Characterizing inherited retinal diseases involves a detailed medical history, clinical examination with testing of visual function, multimodal retinal imaging as well as molecular genetic testing. This may facilitate a distinction between different inherited retinal diseases, as well as a differentiation from monogenic systemic diseases with retinal involvement, and from mimicking diseases.

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Effect of smoking on macular function and retinal structure in retinitis pigmentosa

Cited by 7 publications

References 25 publications

Effect of tobacco smoking on outcomes of trabeculectomy

Effect of tobacco smoking on outcomes of trabeculectomy

Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A Review

Diagnosis of Inherited Retinal Diseases

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