Effect of Smoking on Blood Coagulation and Platelet Survival in Man

Mustard, J. F.; Murphy, Edmond A.

doi:10.1136/bmj.1.5334.846

Cited by 123 publications

(27 citation statements)

References 12 publications

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“…Subsequent data, indicating that, under our experimental conditions, the increase in plasma FFA evoked by nicotine was not followed by an increase in liver and plasma triglycerides, fit well with findings obtained by other investigators in human subjects [3,10,11].…”

Section: Discussionsupporting

confidence: 78%

Some Aspects of the Effect of Nicotine on Plasma FFA and Tissue Triglycerides

et al. 1972

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Nicotine given subcutaneously to rats raised the levels of plasma free fatty acids (FFA) and blood glucose, the content of FFA and glycerol in adipose tissue also being increased. The basal lipolysis of adipose tissue obtained from nicotine-treated rats was increased, while the lipolytic effects of norepinephrine or theophylline remained unchanged or were slightly diminished. The rise in plasma FFA was inhibited by the administration of 5-carboxy-3-methylpyrazole, an antilipolytic agent, or of a β-adrenergic blocker. Nicotine failed to raise plasma FFA in previously adrenalectomized rats. However, this effect was restored by the administration of corticosterone. No elevation of lipid content in the liver and heart was observed after single or repeated treatment.

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Section: Discussionsupporting

confidence: 78%

Some Aspects of the Effect of Nicotine on Plasma FFA and Tissue Triglycerides

et al. 1972

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“…Smoking is related to disturbances in blood platelet function. 1 However, it is still not settled whether or not cigarette smoking activates platelets acutely. 2,3 Cigarette smoking increases heart rate and blood pressure, probably through activation of the sympathetic nervous system.…”

mentioning

confidence: 99%

Acute Effects of Cigarette Smoking on Platelet Function and Plasma Catecholamines in Hypertensive and Normotensive Men

Mundal

Hjemdahl

Gjesdal

1998

American Journal of Hypertension

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In this randomized controlled crossover study essential hypertensive men (n ‫؍‬ ‫؍‬ 13) and matched normotensive controls (n ‫؍‬ ‫؍‬ 18) were examined before and during cigarette and sham smoking to assess the acute effects of smoking on platelets and plasma catecholamines. Platelet activity in vivo was determined by measurements of the released ␣-granule constituent ␤-thromboglobulin (␤-TG) in plasma and in urine. Urinary high molecular weight ␤-TG and venous plasma epinephrine increased significantly during smoking in the hypertensive group, but not among the normotensive men. Thus, cigarette smoking induces a mild platelet release reaction and also elicits a significantly higher epinephrine response in hypertensive men compared to normotensive controls. Am J Hypertens 1998;11:677-681 © 1998 American Journal of Hypertension, Ltd.KEY WORDS: ␤-Thromboglobulin, blood pressure, epinephrine, nicotine, platelet function. C igarette smoking is an important risk factor for occlusive cardiovascular disease, especially in hypertensive patients. Smoking is related to disturbances in blood platelet function.1 However, it is still not settled whether or not cigarette smoking activates platelets acutely. 2,3Cigarette smoking increases heart rate and blood pressure, probably through activation of the sympathetic nervous system. ␤-Thromboglobulin (␤-TG) is a platelet-specific protein released from the ␣-granules during the platelet release reaction and is commonly used as a marker of platelet activation. ␤-TG may, however, also be elevated by ex vivo release. To avoid such sampling-and preparation-induced elevation of plasma ␤-TG, urinary ␤-TG can be determined, as small amounts of ␤-TG are excreted by the kidneys. To minimize nonspecific interferences we measured the high molecular weight (HMW) fraction of ␤-TG in urine. The values were adjusted for urinary creatinine and reflect the platelet release reaction in vivo.5 Platelet counts and mean volumes are other relevant platelet function parameters.The aim of the present study was to examine the responses to acute effects of cigarette smoking on platelet function, plasma catecholamines, and the cardiovascular system in hypertensive men and in ageand weight-matched controls. The study design allowed us to compare baseline results between the hypertensive and normotensive group twice, 1 week apart. We also measured the plasma concentrations of fibrinopeptide A (a marker of thrombin generation), as well as nicotine and its main metabolite, cotinine.

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“…The adhesiveness and aggregation of platelets appear to be increased by cigarette smoking [3,9,10], the platelet survival time is shortened [18], and the electrophoretic mobility seems to decrease [10,22]. The same platelet parameters, following treatment with oral contraceptives, show more contra dictory results.…”

Section: Introductionmentioning

confidence: 48%

A Comparative Study of the Effect of Oral Contraceptives and Cigarette Smoking on Platelet Adhesiveness

Strolin‐Benedetti¹,

Gutty²,

Strölin³

1976

Pathophysiol Haemos Thromb

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The aim of this work was to discover to what extent cigarette smoking and oral contraceptives, either separately or in association, are responsible for platelet adhesiveness changes in humans. Platelet adhesiveness has been measured in 77 subjects, smokers and nonsmokers. 47 of these subjects were women both using and not using oral contraceptives. Cigarette smoking significantly increases platelet adhesiveness both in men and women. On the contrary, if no distinction is made in the smoking habits of female volunteers and they are only divided into two groups according to the use or nonuse of oral contraceptives, no significant change in platelet adhesiveness occurs following intake of oral contraceptives.

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Effect of Smoking on Blood Coagulation and Platelet Survival in Man

Cited by 123 publications

References 12 publications

Some Aspects of the Effect of Nicotine on Plasma FFA and Tissue Triglycerides

Some Aspects of the Effect of Nicotine on Plasma FFA and Tissue Triglycerides

Acute Effects of Cigarette Smoking on Platelet Function and Plasma Catecholamines in Hypertensive and Normotensive Men

A Comparative Study of the Effect of Oral Contraceptives and Cigarette Smoking on Platelet Adhesiveness

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