Effect of Small Intestinal Nutrient Infusion on Appetite, Gastrointestinal Hormone Release, and Gastric Myoelectrical Activity in Young and Older Men

MacIntosh, Caroline G.; Horowitz, Michael; Verhagen, M. A. M. T.; Smout, Andreas J.; Wishart, Judith M.; Morris, Howard A.; Goble, Elizabeth A.; Morley, John E.; Chapman, I. T.

doi:10.1111/j.1572-0241.2001.03684.x

Cited by 92 publications

(65 citation statements)

References 29 publications

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“…Postprandial increases in EGG power have been reported (Smout et al, 1980;Stern et al, 1989;Chen et al, 1991;Kaneko et al, 1995;Kobayashi et al, 1998;Riezzo et al, 2000;Chou et al, 2001) previously andMacintosh et al (2001) reportedthe increase in the EGG power ratio during and after intraduodenal glucose infusion in healthy young and old men.…”

Section: Discussionmentioning

confidence: 81%

“…The changes in EGG dominant frequency after glucose intake are similar to the responses to food intake. Whereas some studies (Verhamgen et al, 1998;Macintosh et al, 2001) have shown that the EGG frequency remained unchanged after intraduodenal glucose infusion in healthy young subjects. The mechanism responsible for the increase in EGG dominant frequency during the postprandial period is not understood.…”

Section: Discussionmentioning

confidence: 99%

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Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Misu

Kamiya

Kobayashi

et al. 2004

J. Smooth Muscle Res.

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AbstractsTo investigate the effect of oral glucose intake on gastric motility, we measured gastric myoelectrical activity and gastric emptying on two test conditions: 1) glucose intake and 2) water intake in the same 10 healthy male volunteers (20 to 29 years old). Gastric motility was evaluated with cutaneous-recorded electrogastrography (EGG) for 30 min both on fasting and after glucose or water intake, while gastric emptying was measured using acetaminophen-absorption method. There were no significant changes in EGG dominant frequency after water intake, but the frequency increased significantly after glucose intake. A postprandial dip (i.e., a transient decrease in frequency immediately after the food intake) was observed in 3 subjects after water intake and in 8 subjects following glucose intake. The EGG power ratio was significantly larger after glucose than water intake, with delayed gastric emptying in the former case. These results suggest that glucose is one of the components responsible for postprandial gastric motility.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Misu

Kamiya

Kobayashi

et al. 2004

J. Smooth Muscle Res.

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“…First, only one dose of each peptide was studied; the doses were chosen from our previous studies and aimed to match physiological plasma concentrations of both CCK and GLP-1. Second, only male subjects were investigated as pre- vious findings suggest that young male volunteers have the highest capacity to regulate energy intake in response to energy manipulation (21,22). As a consequence, our observations are valid for young male subjects but cannot necessarily be extrapolated to female subjects.…”

Section: Discussionmentioning

confidence: 99%

Interaction between GLP-1 and CCK-33 in inhibiting food intake and appetite in men

Gutzwiller

Degen

Matzinger

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

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. Interaction between GLP-1 and CCK-33 in inhibiting food intake and appetite in men. Am J Physiol Regul Integr Comp Physiol 287: R562-R567, 2004. First published April 22, 2004 10.1152/ajpregu.00599.2003.-Glucagon-like peptide-1 (GLP-1) and CCK-33 were intravenously infused alone or in combination into normal weight men for 60 min before they were served a lunch of ham sandwiches, chocolate mousse, and orange juice. Infusion of GLP-1 (dose: 0.9 pmol ⅐ kg Ϫ1 ⅐ min Ϫ1 ) or CCK-33 (dose: 0.2 pmol ⅐ kg Ϫ1 ⅐ min Ϫ1 ) each reduced calorie intake of the test meal. However, simultaneous infusion of these peptide doses reduced calorie intake less than the sum of the peptides' individual effects. Infusions of the same doses of GLP-1 plus CCK-33 had neither individual nor interactive effects on meal size or calorie consumption. The combination of GLP-1 plus CCK-33 induced, however, a significant reduction in hunger feelings in the premeal period (P ϭ 0.036 vs. all other treatments). In summary, intravenous infusion of near physiological doses of CCK-33 and GLP-1 produced specific inhibitions of hunger feeling in men; the simultaneous infusion resulted in an infra-additive reduction in calorie consumption, rejecting thereby the hypothesis that the two peptides exert a positive synergistic effect on food intake compared with the effects observed with infusion of individual peptides. In conclusion, CCK and GLP-1 are meal-related satiety signals that are released from the gastrointestinal tract during food intake. glucagon-like peptide; cholecystokininA SERIES OF REMARKABLE DISCOVERIES and the emergence of obesity as major health problem have stimulated research efforts into how the body controls appetite and food intake. The close relationship between the gastrointestinal endocrine system and the brain in regulating food intake and satiety requires a coordinated interplay in which circulating hormones convey information about food intake and appetite to brain pathways that control eating. However, little is known about which physiological signals interact to control human eating. To further explore the role of specific digestive signals, we investigated the potential interaction of two preabsorptive satiety signals, CCK and glucagon-like peptide-1 (GLP-1). Both peptides are two classical gastrointestinal hormones that are released into the circulation in response to meal consumption (14, 17); compelling evidence has accumulated in the past years to document that each participates in the control of appetite in healthy volunteers, but also in patients with obesity or diabetes type II (3,8,11,15,[25][26][27]. As mentioned before, the control of human eating habits is, however, highly complex and our understanding of appetite regulation is far from complete. In many areas our knowledge is only rudimentary. More important, the interactions between individual signals and their integration into the control system have hardly been explored.From studies in animals and humans it is known that individual satiety signals can interact:...

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“…GLP-1 is secreted from intestinal L-cells in response to the absorption of glucose, other sugars, fatty acids and to a minor extent amino acids (MacIntosh et al 2001;Feinle et al 2002;Brubaker & Anini 2003). The GLP-1 secretory actions of metabolizable nutrients may be linked to cellular ATP generation, K ATP channel blockade and elevation of intracellular Ca 2þ (Gribble & Reimann 2002).…”

Section: Introductionmentioning

confidence: 99%

Targeting β-cell cyclic 3′5′adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review

Furman

Pyne

Flatt³

et al. 2004

Journal of Pharmacy and Pharmacology

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Cyclic 3'5'AMP is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet -cell, where it is formed by the activity of adenylyl cyclase, especially in response to the incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide). These hormones are secreted from the small intestine during and following a meal, and are important in producing a full insulin secretory response to nutrient stimuli. Cyclic AMP influences many steps involved in glucose-induced insulin secretion and may be important in regulating pancreatic islet -cell differentiation, growth and survival. Cyclic AMP (cAMP) itself is rapidly degraded in the pancreatic islet -cell by cyclic nucleotide phosphodiesterase (PDE) enzymes. This review discusses the possibility of targeting cAMP mechanisms in the treatment of type 2 diabetes mellitus, in which insulin release in response to glucose is impaired. This could be achieved by the use of GLP-1 or GIP to elevate cAMP in the pancreatic islet -cell. However, these peptides are normally rapidly degraded by dipeptidyl peptidase IV (DPP IV). Thus longer-acting analogues of GLP-1 and GIP, resistant to enzymic degradation, and orally active inhibitors of DPP IV have also been developed, and these agents were found to improve metabolic control in experimentally diabetic animals and in patients with type 2 diabetes. The use of selective inhibitors of type 3 phosphodiesterase (PDE3B), which is probably the important pancreatic islet -cell PDE isoform, would require their targeting to the islet -cell, because inhibition of PDE3B in adipocytes and hepatocytes would induce insulin resistance.

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Effect of Small Intestinal Nutrient Infusion on Appetite, Gastrointestinal Hormone Release, and Gastric Myoelectrical Activity in Young and Older Men

Abstract: Our findings indicate that aging is associated with nutrient-specific changes in appetite, hormonal, and gastric myoelectrical (EGG) responses to i.d. nutrients. An enhanced satiating effect of small intestinal carbohydrates may potentially contribute to the anorexia of aging.

Cited by 92 publications

References 29 publications

Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Interaction between GLP-1 and CCK-33 in inhibiting food intake and appetite in men

Targeting β-cell cyclic 3′5′adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review

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