Effect of Sleeve Gastrectomy on Thyroid Hormone Levels

Abstract

This is the first study to evaluate changes in thyroid hormone levels following LSG for morbid obesity. TSH decrease and steady levels of FT4 are expected following LSG. These findings are comparable to reported changes following LRYGB. TSH decrease was not associated with EWL. Further studies are required to elucidate the exact mechanism of this effect.

Effect of Weight Loss after Bariatric Surgery on Thyroid-Stimulating Hormone Levels in Patients with Morbid Obesity and Normal Thyroid Function

“…The mechanism and the clinical implications of this alteration remains uncertain. Furthermore, the effect of bariatric surgery on postoperative thyroid function remains incompletely understood with previous studies showing contradictory results regarding the variation of TSH after bariatric surgery and the relation of TSH variation with postoperative weight loss [12][13][14][15][16][17][18][19]. Therefore, our aim was to evaluate the effect of weight loss after bariatric surgery on TSH variation in patients with morbid obesity and normal thyroid function.…”

Effect of Laparoscopic Sleeve Gastrectomy on Clinical Hypothyroidism in Morbidly Obese Patients

“…Abu-Ghanem et al [15] found significant decrease in TSH with no change in FT4 in patients after LSG compared to results seen after LRYGB by Moulin et al and Chikunguwoet al in euthyroid patients [8,9].…”

“…The exact mechanism of improvement of thyroid dysfunction status after bariatric surgery related not only to weight loss but also to the hormonal change after LSG, LRYGB as hypothesized by different studies in which the level of TSH reduction was not directly correlated to the EWL [4,8,15].…”

“…Improved thyroid status has been reported among obese patients following other bariatric surgical procedures [4][5][6][7][8][9][10][11][12], while few studies have been published on the effect of LSG on thyroid status [13][14][15].…”

Gender differences in thyroid function and obesity among finnish women and men. The FIN-D2D-study

“…Following weight loss, fT3 levels decreased and fT4 increased, with no changes in serum TSH [11]. The mean TSH levels declined from 2.45 mU/L to 1.82 mU/L, but there was no change in fT4 -levels within 6-12 months after weight loss, as determined by sleeve gastrectomy of 38 morbidly obese subjects [12].…”