Effect of sleep stages on measurements of passive respiratory mechanics in infants with bronchiolitis

Pratl, B; Steinbrugger, B; Weinhandl, Elisabeth; Zach, M

doi:10.1002/(sici)1099-0496(199904)27:4<273::aid-ppul8>3.0.co;2-v

Cited by 7 publications

(4 citation statements)

References 22 publications

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“…Sleep quality is relatively important for children's mental and physical development [13][14][15]. This is the first study to analyze sleep quality (including sleep time and frequency of waking up at night) in children with bronchiolitis undergoing nebulizing treatment.…”

Section: Discussionmentioning

confidence: 99%

“…In case of severe nasal congestion, a child might resort to open-mouth breathing and prone to dyspnea caused by tracheal obstruction, which may cause respiratory failure in severe cases [10,11]. Infants may be prone to vomit due to frequent coughing at night that affect their sleeping quality, day time activities and mental status as well as recovery of the body's immune system [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analysis of randomized controlled trials

Hsieh

Chen

et al. 2020

BMC Pediatr

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Background Inhaled hypertonic saline (HS) has shown benefit in decreasing airway edema in acute bronchiolitis which is the most common lower respiratory infection resulting in dyspnea among infants under 2 years old. The aim of this systematic review and meta-analysis was to evaluate the efficacy and safety of HS in the implementation of treatment with nebulized HS among children with bronchiolitis. Methods A systematic literature search was conducted using Cochrane Library, PubMed, EMBASE and Airiti Library (Chinese Database) for randomized controlled trials from inception to July 2019. We calculated pooled risk ratios (RR), mean difference (MD) and 95% CI using RevMan 5.3 for meta-analysis. Results There were 4186 children from 32 publications included. Compared to the control group, the HS group exhibited significant reduction of severity of respiratory distress, included studies used the Clinical Severity Score (n = 8; MD, − 0.71; 95% CI, − 1.15 to − 0.27; I2 = 73%) and full stop after Respiratory Distress Assessment Instrument (n = 5; MD, − 0.60; 95% CI, − 0.95 to − 0.26; I2 = 0%) for evaluation respectively. Further, the HS group decreased the length of hospital stay 0.54 days (n = 20; MD, − 0.54; 95% CI, − 0.86 to − 0.23; I2 = 81%). Conclusions We conclude that nebulization with 3% saline solution is effective in decreasing the length of hospital stay and the severity of symptoms as compared with 0.9% saline solution among children with acute bronchiolitis. Further rigorous randomized controlled trials with large sample size are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analysis of randomized controlled trials

Hsieh

Chen

et al. 2020

BMC Pediatr

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“…For example, Hayden et al 31 undertook bronchial challenge tests in 11 infants in order to compare the results using the standard technique for obtaining forced expiratory F-V curves with their new technique, in which lung volume was raised before the squeeze was applied. Pratl et al 32 undertook a study which showed that sleep state materially affected the results of lung function measurements, using the passive expiration technique in infants; they concluded that it was important to monitor sleep state when performing lung function tests. Almost 23% of studies were used to evaluate the efficacy of various medications or treatment modalities.…”

Section: How Are Lung Function Tests Being Used In Infants At the Prementioning

confidence: 99%

What is the role of tests of lung function in the management of infants with lung disease?

Godfrey

Bar‐Yishay

Avital

et al. 2003

Pediatric Pulmonology

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This review considers whether there is a role for lung function tests in the clinical management of infants with lung disease. The purpose of testing lung function in older subjects, the tests available for infants, and the practical problems of testing lung function in infants are considered. After reviewing all the facts, we suggest that there are four situations in which lung function testing should be recommended for infants, as follows: (1) the infant who presents with unexplained tachypnea, hypoxia, cough, or respiratory distress in whom a definitive diagnosis is not apparent from physical examination and other, less difficult investigations; (2) the infant with severe, continuous, chronic obstructive lung disease who does not respond to an adequate clinical trial of combined corticosteroid and bronchodilator therapy; (3) the infant with known respiratory disease of uncertain severity in whom there is need to justify management decisions; and (4) research and development. A review of 62 recent publications to determine how lung function tests are being used at the present time showed that they are being used overwhelmingly for research. The role of lung function testing in the clinical management of infants has not been established, and research is needed to clarify this situation. We suggest that such studies should explore the role of lung function tests in infants with specific symptoms, signs, or diagnoses, taking into account information from other types of investigation and the cost/benefit/risk ratios.

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“…[11][12] Infants may also be prone to vomiting milk due to frequent coughing during the night, which can affect their sleep quality, and in turn affect their activity and mental status during the day and is also closely related to recovery of the body's immune system. [13][14][15][16] Approximately 50 Usually, normal saline is employed as the diluent in nebulizers; the principle is that it uses oxygen flow to vaporize water molecules or drugs and allow these to be breathed in through the mouth and nose and spread to the respiratory tract and lungs with the airflow. After the alveolar capillaries absorb the molecules, the drugs then dilute the secretions in the respiratory tract, induce expectoration, and relieve symptoms of bronchospasm.…”

mentioning

confidence: 99%

Exploring the Efficacy of Using Hypertonic Saline for Nebulizing Treatment in Children with Bronchiolitis: a Meta-Analysis of Randomized Controlled Trials

Hsieh

Chen

et al. 2020

Preprint

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Introduction: Acute bronchiolitis is the most common lower respiratory infection in children. It is particularly prone to dyspnea among children under two years old. Inhaled hypertonic saline (HS) has recently been shown to be a favorable therapy, because of its facility to draw fluid from the submucosa and adventitial spaces, decreasing airway edema. The aim of this systematic review and meta-analysis was to evaluate the efficacy and safety of HS in the implementation of vapor treatment among children with bronchiolitis.Methods: A systematic literature search was conducted using Cochrane Library, PubMed, EMBASE and Airiti Library (Chinese Database) for randomized controlled trials from inception to July 2019. We calculated pooled risk ratios (RR), mean difference (MD) and 95% CI using RevMan 5.3 for meta-analysis.Results: In total, 4186 children from 32 publications were included. Compared to the control group, the HS group exhibited significantly reducing the level of severity of respiratory distress, included studies used the Clinical Severity Score (95% CI −1.15, −0.27, I² = 73%) and Respiratory Distress Assessment Instrument (95% CI −0.95, −0.26, I²= 0%) for evaluation respectively. Further, the HS group decreased the length of hospital stay 0.54 days (95% CI −0.86, −0.32, I²= 81%). Conclusion: We conclude that nebulized with 3% saline solution is effective in decreasing the length of hospital stay and the severity of symptoms as compared with 0.9% saline solution among children with acute bronchiolitis. Further rigor randomize controlled trails with large sample size are needed.

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Effect of sleep stages on measurements of passive respiratory mechanics in infants with bronchiolitis

Cited by 7 publications

References 22 publications

Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analysis of randomized controlled trials

Exploring the efficacy of using hypertonic saline for nebulizing treatment in children with bronchiolitis: a meta-analysis of randomized controlled trials

What is the role of tests of lung function in the management of infants with lung disease?

Exploring the Efficacy of Using Hypertonic Saline for Nebulizing Treatment in Children with Bronchiolitis: a Meta-Analysis of Randomized Controlled Trials

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