Effect of sleep apnea syndrome on the circadian profile of cortisol in obese men

Dadoun, F.; Darmon, Patrice; Achard, Vincent; Boullu-Ciocca, Sandrine; Philip-Joët, F.; Alessi, Marie‐Christine; Rey, Marc; Grino, Michel; Dutour, Anne

doi:10.1152/ajpendo.00126.2007

Cited by 46 publications

(36 citation statements)

References 40 publications

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“…Our findings are in line with those of Vgontzas et al [22] who showed increased nightly cortisol concentrations in obese apneic patients as compared with obese controls and a trend to reduced cortisol concentrations after CPAP therapy. In contrast, Dadoun et al [23] found no significant differences in cortisol concentrations between obese OSAS patients and obese controls, which may possibly be because of a small number of participants and a distinctly lower mean AHI as compared with that of our study. Other studies focused at single time points in the morning and found no changes in cortisol concentrations upon CPAP therapy [24][25][26].…”

Section: Discussioncontrasting

confidence: 99%

“…Therefore, we included a comparatively high number of participants into this study. This gain possibly accounts for the significant differences in cortisol concentrations after CPAP therapy in our study, where other studies showed trends or failed significance [22,23]. As previously shown, small changes in HPA axis activation within the reference range are also considered to be crucial and are known to be related to, for example, the metabolic syndrome [14,37,38].…”

Section: Discussionsupporting

confidence: 60%

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Continuous positive airway pressure therapy decreases evening cortisol concentrations in patients with severe obstructive sleep apnea

et al. 2009

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 60%

Continuous positive airway pressure therapy decreases evening cortisol concentrations in patients with severe obstructive sleep apnea

et al. 2009

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“…However, another reported that OSAS was not associated with any change in the level of salivary or plasma cortisol rhythmicity [29]. In the present study, since no statistically significant differences in the serum cortisol concentrations at each time-point were found between healthy subjects, severe OSAS patients and severe OSAS patients treated with CPAP, the mechanism of induction of hPer1 mRNA at 02:00 h in OSAS patients may not be related to the signalling pathway via GRE.…”

Section: Glucocorticoid Signals To the Mammalian Clock Gene Per1contrasting

confidence: 54%

Clock gene dysfunction in patients with obstructive sleep apnoea syndrome

Burioka

Koyanagi²,

Endo

et al. 2008

European Respiratory Journal

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Clock genes regulate mammalian circadian rhythms, and dysfunction of clock genes can contribute to various disorders. To investigate whether obstructive sleep apnoea syndrome (OSAS) influences clock gene function, the present authors examined Period1 (Per1) mRNA expression in vitro and in vivo.In eight healthy subjects and eight OSAS patients, plasma noradrenaline, serum interleukin (IL)-6, high-sensitivity C-reactive protein (hsCRP) and Per1 mRNA expression in peripheral whole blood were measured. Expression of Per1 mRNA in cultured cells was examined under IL-6 or noradrenaline stimulation in vitro. After noradrenaline was administered to mice in vivo, Per1 mRNA expression in the brain was examined.The concentrations of serum IL-6, hsCRP and plasma noradrenaline were elevated in OSAS patients, but improved by continuous positive airway pressure (CPAP) therapy. Per1 mRNA expression in the peripheral blood significantly decreased at 02:00 h by CPAP in OSAS patients. Stimulation with IL-6 did not directly induce Per1 mRNA in vitro. Administration of noradrenaline induced Per1 mRNA in the cerebral cortex of mice in vivo.The current study revealed that obstructive sleep apnoea syndrome caused clock gene dysfunction, and continuous positive airway pressure helped to improve it. Sympathetic activation and elevation of the plasma noradrenaline concentration in obstructive sleep apnoea syndrome may be one of the factors involved in disorders of Period1 mRNA expression.

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“…Since OSAS causes an increase in sympathetic activity and may increase cortisol levels [9,14], it can be speculated that patients with OSAS are at higher risk of developing CSC than the general population. We found that 22% of our patients with CSC also suffered from OSAS, whereas OSAS is less frequently reported (2-4%) in the general population [15].…”

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea in patients with central serous chorioretinopathy

Kloos

Laube

Thoelen

2008

Graefes Arch Clin Exp Ophthalmol

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Background Patients with central serous chorioretinopathy (CSC) show an increased sympathetic activity compared to controls. Additionally, there are several reports of increased corticosteroid and catecholamine levels in these patients. Obstructive sleep apnea syndrome (OSAS) has been shown to enhance sympathetic activity depending on severity. Respiratory disturbance increases urinary catecholamine secretion and is associated with the occurance of hypertension in a dose dependent manner. Therefore we hypothesize that OSAS may act as a risk factor for the development of CSC. Methods Patients with active CSC or with pigment epithelial disturbances after CSC were contacted to answer a questionnaire about general health, drugs and sleeping habits and to complete the Epworth Sleepiness Scale (ESS) score, a widely used subjective measure of daytime sleepiness. Patients with an ESS score of >10 were referred to our department of pulmonary medicine for evaluating of respiratory disturbance in sleep. ResultsWe identified 56 consecutive patients with angiographic criteria for acute CSC or pigment epithelial defects after CSC, seven (12.5%) of whom were excluded because of a history of systemic or topic corticosteroid use. Thirtysix (73.5%) of the remaining 49 patients returned the questionnaire. Fourteen (38.8%) had an ESS score of >10. They were referred to the Department of Pulmonary Medicine. In eight (22.2%) of these patients, a diagnosis of obstructive sleep apnea syndrome was confirmed. Conclusions We found that 22% of the patients with acute or chronic CSC in this case series also suffered from OSAS, whereas in the general population OSAS is considerably less frequently reported (2-4%). OSAS therefore may act as a risk factor for the development of CSC. However, prospective controlled data is needed to definitely evaluate the possible association between CSC and OSAS. Also the clinical course of CSC during treatment of OSAS would be of particular interest.

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Effect of sleep apnea syndrome on the circadian profile of cortisol in obese men

Cited by 46 publications

References 40 publications

Continuous positive airway pressure therapy decreases evening cortisol concentrations in patients with severe obstructive sleep apnea

Continuous positive airway pressure therapy decreases evening cortisol concentrations in patients with severe obstructive sleep apnea

Clock gene dysfunction in patients with obstructive sleep apnoea syndrome

Obstructive sleep apnea in patients with central serous chorioretinopathy

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