Effect of Size on Other Physical Properties of Granules and Their Corresponding Tablets

Marks, Alan M.; Sciarra, John J.

doi:10.1002/jps.2600570330

Cited by 32 publications

(10 citation statements)

References 9 publications

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“…Fan et al2 noted that flowability was improved with larger particles and narrower particle size distribution. However, there is an increase in flowability as the size of granules decreases in some cases 10. Nevertheless, when the particle size was reduced even more the flowability decreased.…”

Section: Introductionmentioning

confidence: 95%

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Role of FDG‐PET as a biological marker for predicting the hypoxic status of tongue cancer

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Section: Introductionmentioning

confidence: 95%

“…The weight variation of tablets decreases with decrease in granule size 10. Fan et al2 noted that blends with good flowability have low tablet weight variation and good content uniformity.…”

Section: Introductionmentioning

confidence: 99%

Role of FDG‐PET as a biological marker for predicting the hypoxic status of tongue cancer

et al. 2011

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“…Repose angle (a) was calculated by the equation: tan (a) = height/(0.5 * base). Friability was assayed based on a method reported in literature (Marks, Sciarra, 1968), and the percentage of weight loss for the resulting granulates was calculated. The average of two determinations was recorded for each of the mentioned tests.…”

Section: Pharmacotechnical Characterization Of the Granulatesmentioning

confidence: 99%

Application of multivariate techniques in the evaluation of melt granulation products

Andrade

2011

Braz. J. Pharm. Sci.

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In this work, principal component analysis and cluster analysis were applied as helping tools to extract useful information in the development of formulations and manufacturing processes of melt granulates. Two melt granulation processes that differ in the shear stress applied to the solid bed during melting step were designed. These processes employ equipment frequently used in the local pharmaceutical industry. The selected binders include both hydrophilic and hydrophobic excipients, which were used alone or in binary mixtures. Granulates were characterized regarding their physicomechanical properties, including their compaction behavior. The resulting tablets were also evaluated. The selected multivariate statistical methods proved to be useful in facilitating the interpretation of the collected data and the study of the properties of granulates and tablets, as well as the selection of more efficient production processes.Uniterms: Granulates/evaluation. Tablets/evaluation. Granulates/manufacturing processes. Melt granulates/manufacturing processes. Tablets/production processes. Principal component analysis/ application. Cluster analysis/application. Pharmaceutical formulations/development. Melt granulation/ application.Neste trabalho, foram aplicadas as técnicas de análise de componentes principais e de análise de agrupamentos para extrair informações úteis no desenvolvimento de formulações e de processos de produção de granulados por fusão. Desenharam-se dois processos de granulação por fusão que apresentam diferenças na tensão de cisalhamento aplicada ao leito sólido durante a etapa de fusão. Esses processos empregam equipamentos frequentemente usados na indústria farmacêutica local. Os ligantes escolhidos incluíram excipientes tanto hidrofílicos quanto hidrofóbicos, utilizados de forma individual ou em misturas binárias. Os granulados foram caracterizados quanto às suas propriedades físico-mecânicas, incluindo seu desempenho no processo de compactação. Os comprimidos resultantes também foram avaliados. Os métodos de análise multivariada escolhidos provaram ser úteis para facilitar a interpretação dos dados coletados e o estudo das propriedades dos granulados e dos comprimidos, bem como a seleção de processos de produção mais eficientes.

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“…The effect of granule-size crystal formation and granulometry of compressed particles on the properties of some tablet formulations was presented (344)(345)(346). Also a method was described for the measurement of granulometry and porosity of solids by X-ray scattering (347).…”

Section: Pharmaceutical Technologymentioning

confidence: 99%

Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics

Bernardo¹,

Russo²

1969

Journal of Pharmaceutical Sciences

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Effect of Size on Other Physical Properties of Granules and Their Corresponding Tablets

Cited by 32 publications

References 9 publications

Role of FDG‐PET as a biological marker for predicting the hypoxic status of tongue cancer

Role of FDG‐PET as a biological marker for predicting the hypoxic status of tongue cancer

Application of multivariate techniques in the evaluation of melt granulation products

Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics

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