Effect of size of a secundum atrial septal defect on shunt volume

Fuse, Shigeto; Tomita, Hideshi; Hatakeyama, Kinya; Kubo, Nobuhiko; Abe, Naomi

doi:10.1016/s0002-9149(01)02134-8

Cited by 28 publications

(20 citation statements)

References 12 publications

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“…Because of the bigger sample size from the SUR group and its broad clinical spectrum, SUR patients were randomly selected from the computer data in a 2:1 (SUR : ASO) fashion with similar age (±5 years), gender, sPAP (±10 mm Hg), date of the procedure (±6 months), Qp/Qs shunt ratio (±0.7), and size of the defect (±0.25 cm 2 /m 2 ). We estimated the size of the defects in area using the orthogonally measured diameters by an ellipse area equation (area = πab) and then the size was corrected to the body surface area in square meters 20 …”

Section: Methodsmentioning

confidence: 99%

Transcatheter versus Surgical Closure of Secundum Atrial Septal Defect in Adults: Impact of Age at Intervention. A Concurrent Matched Comparative Study

Rosas

Zabal

García-Montes

et al. 2007

Congenital Heart Disease

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The efficacy for closure ASD was similar in both groups. The higher morbidity observed in SUR group was observed only in the patients submitted to the procedure with age >40 years. The length of hospital stay was shorter in the ASO group. Surgical closure is a safe and effective treatment, especially in young adults. There is certainly nothing wrong with continuing to do surgery in countries where the resources are limited.

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Section: Methodsmentioning

confidence: 99%

Transcatheter versus Surgical Closure of Secundum Atrial Septal Defect in Adults: Impact of Age at Intervention. A Concurrent Matched Comparative Study

Rosas

Zabal

García-Montes

et al. 2007

Congenital Heart Disease

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“… 1 Pulmonary cardiac output (CO) (QP) divided by systemic CO (QS) is used to quantify the degree of left-to-right shunting (QP/QS). The magnitude of left-to-right shunting has been related to the size of the ASD 2 and the compliance of the ventricles. 3 However, the effect of exercise on left-to right shunting is less well known.…”

Section: Introductionmentioning

confidence: 99%

Changes in blood volume shunting in patients with atrial septal defects: assessment of heart function with cardiovascular magnetic resonance during dobutamine stress

Stephensen

Steding‐Ehrenborg

Thilén

et al. 2016

European Heart Journal - Cardiovascular Imaging

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BackgroundThe purpose of this study was to determine the effect of stress on left-to-right shunting in patients with atrial septal defect (ASD) and to investigate if the degree of shunting, cardiac output (CO), and right ventricular (RV) volumes are related to exercise capacity.MethodsTwenty-six patients with a secundum ASD and 16 healthy volunteers were studied with rest/stress cardiac magnetic resonance using 20 µg/kg/min dobutamine and 0.25–0.75 mg atropine to quantify CO, pulmonary to systemic flow ratio (QP/QS), and left ventricular (LV) and RV volumes. Peak oxygen uptake (VO2peak) was determined on ergospirometry.ResultsIn patients with ASD the QP/QS decreased from 2.0 ± 0.2 at rest to 1.5 ± 0.1 (P < 0.001) during dobutamine stress (n = 20) and shunt volume per heartbeat decreased from 70 ± 9 to 38 ± 9 mL (P < 0.001). However, absolute shunt volume per minute was unchanged (5.1 ± 0.8 vs. 4.5 ± 1.0 L/min, P = 0.32) explained by a higher increase in systemic CO during stress (90 ± 11%) compared with pulmonary CO (43 ± 7%, P < 0.001). In ASD patients, VO2peak correlated with aortic CO during stress (r = 0.77) and QP/QS at rest (r = −0.48) but not during stress (P = 0.09). VO2peak did not correlate with RV volumes in patients.ConclusionPulmonary to systemic flow ratio and shunt volume per heartbeat decrease during stress in ASD patients. This may be explained by an enhanced LV diastolic function during stress and may have implications to detect disturbances in LV compliance in ASD patients. A high systemic CO during stress is a strong predictor of exercise capacity.

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“…14 size, as measured using 2D transthoracic echocardiography. 6 In that study, defect area (mm 2 ) divided by BSA (m 2 ) was used to compare Qp/Qs among patients with different body sizes. 6 …”

Section: Discussionmentioning

confidence: 99%

Influence of Left Ventricular Stiffness on Hemodynamics in Patients With Untreated Atrial Septal Defects

Kurishima

Inuzuka

Kuwata

et al. 2015

Circ J

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Effect of size of a secundum atrial septal defect on shunt volume

Cited by 28 publications

References 12 publications

Transcatheter versus Surgical Closure of Secundum Atrial Septal Defect in Adults: Impact of Age at Intervention. A Concurrent Matched Comparative Study

Transcatheter versus Surgical Closure of Secundum Atrial Septal Defect in Adults: Impact of Age at Intervention. A Concurrent Matched Comparative Study

Changes in blood volume shunting in patients with atrial septal defects: assessment of heart function with cardiovascular magnetic resonance during dobutamine stress

Influence of Left Ventricular Stiffness on Hemodynamics in Patients With Untreated Atrial Septal Defects

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