Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects

Hammett, C.; Oxenham, Helen; Baldi, James C.; Doughty, Robert N.; Ameratunga, Rohan; French, John K.; White, Harvey D.; Stewart, Ralph

doi:10.1016/j.jacc.2004.09.030

Cited by 76 publications

(56 citation statements)

References 8 publications

(1 reference statement)

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“…16 A previous study involving hypoxic training (O 2 , 15%) for middle-aged obese subjects over 4 weeks indicated that the reduction in body fat content with training was greater in the hypoxic group than in the normoxic group. 18,19 In this study, the weight, BMI, body fat percentage and waist circumference were reduced after hypoxic training, regardless of physique, supporting the results of previous studies. …”

Section: Discussionsupporting

confidence: 89%

Influences of Short-Term Normobaric Hypoxic Training on Metabolic Syndrome-Related Markers in Overweight and Normal-Weight Men

Shin

Matsuoka

2018

J Men's Health

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Section: Discussionsupporting

confidence: 89%

Influences of Short-Term Normobaric Hypoxic Training on Metabolic Syndrome-Related Markers in Overweight and Normal-Weight Men

Shin

Matsuoka

2018

J Men's Health

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“…In agreement with previous reports on middle-aged/older adults without clinical disease (16,21,24,30), the exercise intervention did not alter plasma markers of inflammation, nor were markers of oxidative stress or antioxidant capacity affected. These observations indicate that modulation of expression of proinflammatory/-oxidant genes by regular aerobic exercise is not associated with changes in these markers of the oxidative and inflammatory properties of the blood.…”

Section: Amelioration With Habitual Aerobic Exercisesupporting

confidence: 92%

Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise

Gano

Donato

Pierce

et al. 2011

Physiological Genomics

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We tested the hypothesis that peripheral blood mononuclear cells (PBMC) of older adults demonstrate a proinflammatory/-oxidative gene expression profile that can be improved by regular aerobic exercise. PBMC were isolated from young (n ϭ 25, 18 -33 yr) and middle-aged/older (n ϭ 40, 50 -76 yr) healthy adults. The older adults had greater mRNA expression (real-time RT-PCR) of the proinflammatory/-oxidant transcription factor nuclear factor-B (1.58-fold, P Ͻ 0.05) and receptor for advanced glycation end products (1.12-fold, P Ͻ 0.05), the proinflammatory cytokines tumor necrosis factor-␣ (1.90-fold, P Ͻ 0.05) and monocyte chemoattractant protein-1 (1.47-fold, P Ͻ 0.05), and the oxidant-producing enzymes nicotinamide adenine dinucleotide phosphate-oxidase (0.91-fold, P Ͻ 0.05) and inducible nitric oxide synthase (2.60-fold, P Ͻ 0.05). In 11 subjects (58 -70 yr), maximal oxygen consumption (ϩ11%) and exercise time (ϩ19%) were increased (both P Ͻ 0.001), and expression of the above proinflammatory/-oxidative genes was or tended to be decreased in PBMC after vs. before 2 mo of aerobic exercise (brisk walking ϳ6 days/wk, 50 min/day, 70% of maximal heart rate). Expression of interleukin-6 was not different with age or exercise intervention. Age group-and exercise intervention-related differences in gene expression were independent of other factors. PBMC of healthy older adults demonstrate increased expression of several genes associated with inflammation and oxidative stress, which is largely ameliorated by habitual aerobic exercise. This proinflammatory/-oxidative gene signature may represent a therapeutic target for lifestyle and pharmacological prevention and treatment strategies. aging; oxidative stress; inflammation; cytokines; immune cells AGE IS THE MAJOR RISK FACTOR for cardiovascular diseases (CVD), largely as the result of vascular dysfunction (18). Chronic low-grade inflammation and oxidative stress are believed to play important roles in the development of vascular disorders with age (1, 29, 31). Plasma markers of inflammation and oxidative stress often are elevated in older adults (9,11,13). Proinflammatory changes to the intimal layer of arteries with aging have been reported on autopsy (34). Moreover, we recently found increased expression of the redox-sensitive proinflammatory nuclear transcription factor nuclear factor B (NF-B), the proinflammatory cytokines tumor necrosis factor-␣ (TNF-␣), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), and the oxidant enzyme nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase in vascular endothelial cells obtained from older compared with young adults (9, 10). The proinflammatory/redox-sensitive proteins receptor for advanced glycation end products (RAGE) and inducible nitric oxide synthase (iNOS) also have been found to increase with age (2, 15).Although evidence is accumulating for inflammation and oxidative stress in plasma and vascular cells/tissues with advancing age in humans, relatively little is known about the possibility of such...

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“…Participation in an exercise training program for 6 mo in patients with stable chronic heart failure (CHF) significantly decreases the mRNA expression of TNF-α, IL-6, IL-1β in skeletal muscle, compared to the healthy individuals [74] . On the other hand, some studies demonstrate that the levels of pro-inflammatory cytokines are not significantly altered after exercise training in the obese individuals and healthy elderly [75][76][77] . This discrepancy may be derived from differences in experimental design and disease status of the subjects.…”

Section: Effect Of Chronic Exercise On Inflammationmentioning

confidence: 99%

Effects of interventions on oxidative stress and inflammation of cardiovascular diseases

Lee¹,

Park²,

Zuidema³

et al. 2011

WJC

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Excessive oxidative stress and low-grade chronic inflammation are major pathophysiological factors contributing to the development of cardiovascular diseases (CVD) such as hypertension, diabetes and atherosclerosis. Accumulating evidence suggests that a compromised antioxidant system can lead to excessive oxidative stress in cardiovascular related organs, resulting in cell damage and death. In addition, increased circulating levels of pro-inflammatory cytokines, such as tumor necrosis factor α, interleukin-6 and C-reactive protein, are closely related to morbidity and mortality of cardiovascular complications. Emerging evidence suggests that interventions including nutrition, pharmacology and exercise may activate expression of cellular anti-oxidant systems via the nuclear factor erythroid 2-related factor 2-Kelchlike ECH-associated protein 1 signaling pathway and play a role in preventing inflammatory processes in CVD. The focus of the present review is to summarize recent evidence showing the role of these anti-oxidant and anti-inflammatory interventions in cardiovascular disease. We believe that these findings may prompt new effective pathogenesis-oriented interventions, based on the exercise-induced protection from disease in the cardiovascular system, aimed at targeting oxidant stress and inflammation.

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Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects

Cited by 76 publications

References 8 publications

Influences of Short-Term Normobaric Hypoxic Training on Metabolic Syndrome-Related Markers in Overweight and Normal-Weight Men

Influences of Short-Term Normobaric Hypoxic Training on Metabolic Syndrome-Related Markers in Overweight and Normal-Weight Men

Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise

Effects of interventions on oxidative stress and inflammation of cardiovascular diseases

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