Effect of single doses of pindolol and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients

Bernik, Márcio; Ramos, Renato T.; Hetem, Luiz Alberto B.; Graeff, Frederico Guilherme

doi:10.1016/j.bbr.2017.11.002

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…In the present review, 4 articles included RCTs [12-15], 3 articles included open trials [15-17] and 5 were comparative trials [18-22]. The article from Mantovani et al [15] comprised two different clinical trials, phases 1 (RCT) and 2 (open trial), which were treated as independent trials.…”

Section: Resultsmentioning

confidence: 99%

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Pharmacological and Neuromodulatory Treatments for Panic Disorder: Clinical Trials from 2010 to 2018

Zugliani

Cabo

Nardi

et al. 2019

Psychiatry Investig

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Objective Treatment for panic disorder (PD) have evolved, although there is still a strong unmet need for more effective and tolerable options. The present study summarizes and discusses recent evidence regarding the pharmacological and neuromodulatory treatment of PD. Methods MEDLINE, Cochrane Library, PsycINFO and Thomson Reuters’s Web of Science were searched for clinical trials published between 2010 and 2018. We included all prospective experimental studies including randomized controlled trials (RCT) and other clinical trials with more than 10 patients. Results Only 11 articles met the inclusion criteria, including 4 RCT, 3 open clinical trials and 5 comparative clinical trials. RCT demonstrated efficacy of transcranial magnetic stimulation (TMS) in only one of two trials. Neither pindolol nor d-fenfluramine were effective in blocking flumazenil-induced panic attacks. Augmentation with quetiapine was not superior to placebo. Open trials indicated that escitalopram, vortioxetine and TMS may be effective. Comparative trials did not demonstrate superiority from any drug, but confirmed tranylcypromine, paroxetine, clonazepam and alprazolam as effective options. Conclusion The current study confirmed the efficacy of tranylcypromine, paroxetine, clonazepam, alprazolam and escitalopram. Vortioxetine and TMS, with duration of 4 or more weeks, also seems to be effective. Quetiapine, pindolol and d-fenfluramine were not considered effective compounds.

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Section: Resultsmentioning

confidence: 99%

“…Bernik et al [12] investigated whether acute enhancement of serotonin inhibits PAs. Single doses of either pindolol, d-fenfluramine or placebo were given to drug-free or never treated PD patients before a challenge test with intravenous infusion of flumazenil.…”

Section: Resultsmentioning

confidence: 99%

Pharmacological and Neuromodulatory Treatments for Panic Disorder: Clinical Trials from 2010 to 2018

Zugliani

Cabo

Nardi

et al. 2019

Psychiatry Investig

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show abstract

“…Flumazenil is a GABA A receptor antagonist with anxiogenic properties, 33 responsible for antagonizing the effects of benzodiazepines, such as diazepam, including anxiolytic, sedative and hypnotic effects. In the literature, many researchers have used flumazenil as a tool to identify possible endogenous and exogenous ligands in benzodiazepine receptors in rodents, 34 as well as in adult zebrafish.…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic-like effect of Azadirachta indica A. Juss. (Neem, Meliaceae) bark on adult zebrafish (Danio rerio): participation of the Serotoninergic and GABAergic systems

Silva¹,

Ferreira²,

Rebouças³

et al. 2020

PPIJ

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Psychiatric and Neurological Effects of Cardiovascular Drugs

Govoni¹

2020

Brain and Heart Dynamics

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Effect of single doses of pindolol and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients

Cited by 5 publications

References 43 publications

Pharmacological and Neuromodulatory Treatments for Panic Disorder: Clinical Trials from 2010 to 2018

Pharmacological and Neuromodulatory Treatments for Panic Disorder: Clinical Trials from 2010 to 2018

Anxiolytic-like effect of Azadirachta indica A. Juss. (Neem, Meliaceae) bark on adult zebrafish (Danio rerio): participation of the Serotoninergic and GABAergic systems

Psychiatric and Neurological Effects of Cardiovascular Drugs

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