Effect of single dose of SA 14-14-2 vaccine 1 year after immunisation in Nepalese children with Japanese encephalitis: a case-control study

Genetic and Phenotypic Properties of Vero Cell-Adapted Japanese Encephalitis Virus SA14-14-2 Vaccine Strain Variants and a Recombinant Clone, Which Demonstrates Attenuation and Immunogenicity in Mice

“…15,17,18 Immunization with JEV SA14-14-2 has been shown to result in 88-96% efficacy after a single dose (10 5.4 -10 6.8 plaque-forming units [PFU]/dose, depending on the study [19][20][21][22] ) and has been administered to millions of children with no reported serious adverse events. 15,[23][24][25][26] The World Health Organization (WHO) prequalified the JEV SA14-14-2 vaccine in October of 2013.…”

Immunogenicity and safety of currently available Japanese encephalitis vaccines: A systematic review

“…Sohn et al 52 reported no immediate local or systemic reactions among 86 children received live attenuated SA14-14-2 virus vaccine. The proportions of subjects reporting mild and self-limited symptoms were as followed: elevated temperature (37.5-38℃) 7% (6/86), vomiting 1%(1/86), skin rash 1%(1/86), loss of appetite 1% (1/86), and irritability 1%(1/86).…”

“…51 Live attenuated SA14-14-2 virus vaccine was first used outside of China among Korean children, Sohn et al 52 evaluated the immunogenicity in 68 infants aged 1-3 years old. 65 (96%) of the subjects were seroprotected after the primary vaccination, and the GMT was 188.…”

Product review on the JE vaccine IXIARO

“…Later on, Chinese manufacturers started producing both inactivated and live-attenuated virus vaccines using primary hamster kidney cells for virus propagation. [25][26][27][28] The use of these vaccines has not remained limited to domestic supply, in addition, there has been utilization of the live attenuated SA14-14-2 JE vaccine, which was recently prequalified by the World Health Organization, in national immunization programs in Asia. 29 However, potential safety hazards with live vaccines remain a constant source of controversy in the scientific community and among public-health officials, 25,30,31 with the potential threat of mutagenic reversion into pathogenic strains as the greatest fear among critics.…”