Effect of simvastatin on the ubiquinone synthetic pathway

Laaksonen, Reijo; Jokelainen, Kalle; Tikkanen, Minna; ̈nen, M. Ha ̈rko; Sahi, Timo; Himberg, Jaakko‐Juhani

doi:10.1016/0021-9150(94)94285-4

Cited by 1 publication

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“…This is verified where one study reported a 40% reduction in Coq10 levels over 3 months in healthy individuals treated with 20mg per day of either pravastatin or simvastatin, whilst another in healthy people taking 10mg of atorvastatin daily or 20mg per day of pravastatin did not observe significant decreases in CoQ10 levels, although a higher dose of 80mg per day of atorvastatin administered subsequently for 30 days did result in a 52% reduction in CoQ10 levels [228,229]. In a different study those taking simvastatin 20 mg/day for 4 weeks experienced reduced serum coenzyme Q-10 levels of about 32%, whilst levels in muscle actually increased by up to 47% [230].…”

Section: Statinsmentioning

confidence: 87%

A Review of the Role Micronutrient Status in the Elderly Plays in Their Immune Response to Viral Respiratory Infections and the Potential Compromising Effects Medications Might Cause

Wakeman¹

2020

JAMMR

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The elderly are a growing proportion of the global population. They are more susceptible to non-communicable diseases and respiratory viral diseases like influenza and covid19, which may lead to increased levels of morbidity and mortality than those of a younger generation. It is also reported that co-morbidities, especially diabetes, hypertension and coronary heart disease contribute significantly to the prognosis with these types of infections. That the immune system operates in a less efficient way as an individual ages, is now well understood and likely contributes significantly to this situation. The role of certain micronutrients in maintaining a healthy immune system is well recognised and demonstrated to play an important role both in preventing and controlling infection. However, for a number of reasons many elderly individuals have a less than optimal intake of many of the micronutrients that support the immune system. This review examines the contributory roles an aging immune system, suboptimal intake of micronutrients, comorbidities and the impact of the intake of medications typically used to treat them can play in the outcome of viral respiratory infections. It identifies the need for supplementation, especially in the elderly to support the immune system.

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Section: Statinsmentioning

confidence: 87%

A Review of the Role Micronutrient Status in the Elderly Plays in Their Immune Response to Viral Respiratory Infections and the Potential Compromising Effects Medications Might Cause

Wakeman¹

2020

JAMMR

View full text Add to dashboard Cite

show abstract

Effect of simvastatin on the ubiquinone synthetic pathway

Cited by 1 publication

References 0 publications

A Review of the Role Micronutrient Status in the Elderly Plays in Their Immune Response to Viral Respiratory Infections and the Potential Compromising Effects Medications Might Cause

A Review of the Role Micronutrient Status in the Elderly Plays in Their Immune Response to Viral Respiratory Infections and the Potential Compromising Effects Medications Might Cause

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