Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model

Iwakiri, Kentaro; Oda, Yutaka; Kaneshiro, Yasunori; Iwaki, Hiroaki; Masada, Toshiaki; Kobayashi, Akio; Asada, Akira; Takaoka, Kunio

doi:10.1007/s00776-008-1257-z

Cited by 41 publications

(46 citation statements)

References 25 publications

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“…2 The LA group had a lower (P < 0.01) incidence of ON (20 of this study are consistent with the previous Wndings that oxidative stress and vascular endothelial dysfunction were important mechanisms [6,13]. Oxidative stress develops soon after steroid administration, oxidative injury also occurring within bone [14], which has been demonstrated recently. Based on the previous and the present study, it can be concluded that oxidative stress is an important mechanism in the steroid-induced osteonecrosis rabbit model.…”

Section: Discussionsupporting

confidence: 90%

Lipoic acid prevents steroid-induced osteonecrosis in rabbits

2011

Rheumatol Int

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The objective of this study was to investigate in vivo effects of lipoic acid (LA) in preventing steroid-induced osteonecrosis and the possible pathway in a rabbit model. Sixty rabbits were divided into 2 groups: rabbits were intraperitoneally injected with LA aqueous solution at 36 mg/kg of body weight per day for 4 weeks in Group A and rabbits were injected with physiologic saline (PS) as a control in Group B. At 2 weeks after starting treatment, they were intramuscularly injected once with 20 mg/kg of methylprednisolone acetate (MPSL). The femora were histopathologically examined for the presence of osteonecrosis. The plasma levels of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), glutathione (GSH), endothelin (ET) and malondialdehyde (MDA) were assayed at 2 weeks after the injection of MPSL. The incidence of osteonecrosis was significantly higher in Group B (73.1%) than in Group A (20.8%). The GSH level was higher in Group A than in Group B after the LA injection. The plasma MDA and ET levels were lower in Group A than in Group B at 2 weeks after the MPSL administration. Lipoic acid can prevent the development of steroid-induced osteonecrosis in rabbits. Inhibited oxidative stress and amendment of vascular endothelial dysfunction is a possible mechanism for this effect.

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Section: Discussionsupporting

confidence: 90%

Lipoic acid prevents steroid-induced osteonecrosis in rabbits

2011

Rheumatol Int

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“…Farmakolojik tedavinin etkisini değerlendirmek için yürütülen birçok çalışma mevcuttur. Osteonekroz gelişiminin önlenmesinde bifosfonatlar (20,21), antikoagülanlar (22), lipid düşürücü ajanlar (23)(24)(25) ve antihipertansif (26,27) ilaçlarla yapılmış birçok çalışma mevcuttur. Cerrahi tedavi femur başını koruyucu tedavi ve femur yüzeyinin yenilenmesinde şeklinde ikiye ayrılır.…”

Section: Discussionunclassified

Multiple Sklerozlu Hastada Spastisite ile Karışabilecek Femur Başı Avasküler Nekrozu: Olgu Sunumu

Baygutalp¹,

Işık²,

Şenel³

2014

tod

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SummaryMultiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Disease is often characterized by attacks and remissions. The lesions present various symptoms according to their locations in the CNS. The treatment can be divided into three categories as attack treatment, prophylactic therapy and symptomatic treatment. Glucocorticoids (GC) are used in acute attacks of MS usually in intravenous pulse form for 3-10 days several times in a year and they accelerate the remission of attacks. GC has various positive and negative effects on the musculoskeletal system. Avascular necrosis (osteonecrosis) is a common complication of GC using. GC-induced avascular necrosis is frequently seen in femoral head. GC-induced femoral head avascular necrosis (FHAVN) may occur in patients with MS. FHAVN may be asymptomatic and painless or may cause pain and limitations in the hips. Since hip pain and limitations can be seen in MS patients due to spasticity, FHAVN should be absolutely considered and ruled out in differential diagnosis. In this article, a FHAVN case developed due to high-dose GC using for several times a year in a patient while being followed-up for MS was presented, and the association of these two diseases was discussed in the light of current literature. The aim of this case report is to point out the importance of ruling FHAVN by magnetic resonance imaging (MRI) in MS patients even they have normal direct radiography findings.

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“…Cryogenic and thermal insults have been used to induce osteonecrosis in quadrupeds such as canines [60] and bipeds such as emus [61] . Intramuscular injection of methylprednisolone has been used to develop steroid-induced osteonecrosis in mouse [62] , rat [63] , rabbit [64,65] , pig [66] , and chicken models [18] , where the percent incidence of induced osteonecrosis is dependent on the amount of methylprednisolone injected. These animal models have been used to study the molecular mechanisms of osteonecrosis and assess the usefulness of several therapies over the last few decades.…”

Section: Update On Bench Research and Clinical Applicationsmentioning

confidence: 99%

Osteonecrosis of the femoral head: An update in year 2012

Kaushik

Das²,

Cui³

2012

WJO

135

118

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Osteonecrosis is a phenomenon involving disruption to the vascular supply to the femoral head, resulting in articular surface collapse and eventual osteoarthritis. Although alcoholism, steroid use, and hip trauma remain the most common causes, several other etiologies for osteonecrosis have been identified. Basic science research utilizing animal models and stem cell applications continue to further elucidate the pathophysiology of osteonecrosis and promise novel treatment options in the future. Clinical studies evaluating modern joint-sparing procedures have demonstrated significant improvements in outcomes, but hip arthroplasty is still the most common procedure performed in these affected younger adults. Further advances in joint-preserving procedures are required and will be widely studied in the coming decade.

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Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model

Cited by 41 publications

References 25 publications

Lipoic acid prevents steroid-induced osteonecrosis in rabbits

Lipoic acid prevents steroid-induced osteonecrosis in rabbits

Multiple Sklerozlu Hastada Spastisite ile Karışabilecek Femur Başı Avasküler Nekrozu: Olgu Sunumu

Osteonecrosis of the femoral head: An update in year 2012

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