Effect of Simvastatin on Histopathology of the Heart After 5/6 Subtotal Nephrectomy

Cahyawati, Putu Nita

doi:10.22159/ijap.2019.v11s5.t0105

Cited by 3 publications

(5 citation statements)

References 14 publications

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“…Generally, Simvastatin is a commonly used drug for treating different cardiovascular diseases, especially hypercholesterolemia [ 16 – 19 ], coronary heart disease [ 19 , 20 ], cardiac cell death [ 21 ], myocardial inflammation, and fibrosis [ 14 , 15 , 22 , 24 , 25 , 43 ] due to the inter-relationships between these diseases. Simvastatin can also inhibit the TGF-β1 pathway which is responsible for interstitial fibrosis and cardiomyocyte hypertrophy [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…With the prevalence of chronic alcoholism (especially in adolescents) and its associated cardiovascular diseases, it is important to investigate interventions that may mask or reduce the damaging effects of alcohol on the heart tissues. One such intervention that is gaining popularity, due to its anti-inflammatory and immune-regulatory properties, is Simvastatin [ 13 – 15 ], an FDA-approved drug, primarily used for lowering blood cholesterol levels (hypercholesterolemia) [ 16 – 19 ]. Simvastatin has also been shown to prevent coronary heart disease [ 19 , 20 ], cardiomyocyte death [ 21 ], myocardial inflammation, and fibrosis [ 14 , 22 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Simvastatin has also been shown to prevent coronary heart disease [ 19 , 20 ], cardiomyocyte death [ 21 ], myocardial inflammation, and fibrosis [ 14 , 22 – 24 ]. Furthermore, Simvastatin also prevents myocarditis [ 25 ], improves endothelial functions [ 14 , 15 ], and inhibits the TGF-β1 pathway which triggers the development of interstitial fibrosis and cardiomyocyte hypertrophy [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice

Nchodu,

Efuntayo,

du Preez

et al. 2024

Cardiovasc Toxicol

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Alcohol abuse by adolescents is becoming a serious health concern as they often progress to becoming alcoholics later in life which may lead to heart problems. Chronic alcohol use alters the cardiac function and structure, such as haemodynamic changes, weakening and loss of cardiomyocytes, myocardial fibrosis, and inflammation. Simvastatin is a commonly used drug for the treatment and management of various cardiovascular problems but information on its protective effects against alcohol-induced cardiomyocyte hypertrophy, fibrosis, and inflammation is lacking in the literature. Four-week-old male (n = 5) and female (n = 5) C57BL/6 J mice were assigned to each experimental group: (I) NT—no administration of alcohol or Simvastatin; (II) ALC—2.5 g/Kg/day of 20% alcohol via intraperitoneal injection (i.p.); (III) SIM—5 mg/Kg/day of Simvastatin via oral gavage; (iv) ALC + SIM5—5 mg/Kg/day of Simvastatin via oral gavage followed by 2.5 g/Kg/day of 20% alcohol via i.p.; and (v) ALC + SIM15—15 mg/Kg/day Simvastatin via oral gavage followed by 2.5 g/Kg/day of 20% alcohol via i.p. After the 28-day treatment period, the heart was removed and processed for H&E, Masson’s trichrome, or TNF-α immunolabelling. The area and diameter of cardiomyocytes were measured on the H&E-stained sections. The distribution of collagen or TNF-α expression was quantified using the deconvolution tool of ImageJ software. The results confirmed alcohol-induced toxicity on the cardiomyocytes and Simvastatin reduced alcohol-induced cardiomyocyte hypertrophy, fibrosis, and inflammation in both sexes. This study demonstrated that Simvastatin, an FDA approved and easily accessible drug, may be beneficial in lowering the prevalence of alcohol-induced cardiovascular diseases (especially in adolescents) which will have a huge financial implication on health systems worldwide.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice

Nchodu,

Efuntayo,

du Preez

et al. 2024

Cardiovasc Toxicol

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“…Prosedur operasi diawali dengan melakukan anastesi kombinasi 90 mg/kg BW ketamine and 10 mg/kb BW xylazine secara intra peritoneal. 23…”

Section: Prosedur Penelitianunclassified

Simvastatin Memperbaiki Degerasi Hidropis dan Nekrosis Sel Hepatosit Mencit Subtotal Nefrektomi

Wibawa

Sumadewi

Cahyawati

2022

JBN

Self Cite

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Latar belakang: Gagal ginjal kronik (GGK) merupakan salah satu penyakit dengan tingkat mortalitas yang tinggi. Pada pasien GGK, golongan obat statin digunakan untuk mengatasi kondisi dislipidemia dan mencegah kelainan kardiovaskular. Selama ini banyak penelitian lebih terfokus meneliti efek pemberian statin terhadap kondisi ginjal dibandingkan dengan kondisi hepar. Penelitian ini bertujuan untuk mengetahui efek simvastatin terhadap perubahan pada degenerasi hidropis dan nekrosis sel hepatosit mencit model subtotal nefrektomi. Metode: Lima belas ekor mencit (Mus musculus L.) jantan, galur Swiss, umur 3 bulan, berat badan 30-40 gram digunakan pada penelitian ini. Mencit dibagi menjadi 3 kelompok perlakuan secara random yaitu kelompok subtotal nefrektomi (SN, n=5), kelompok simvastatin dosis 5,2 mg/kgBB (S5, n=5), dan kelompok simvastatin dosis 10,4 mg/kgBB (S10, n=5). Hasil: Hasil pemeriksaan histopatologi menunjukkan bahwa rerata degenerasi hidropis pada kelompok SN (1,240,19), kelompok S5 (0,640,11), dan kelompok S10 (0,920,41). Terdapat perbedaan signifikan pada penilaian degenersi hidropis pada kelompok SN dan kelompok S5 (p<0,05). Rerata degenerasi hidropis pada kelompok SN (1,240,19), kelompok S5 (0,640,11), dan kelompok S10 (0,920,41). Terdapat perbeda an signifikan antara kelompok hewan yang memperoleh simvastatin (S5 dan S10) dengan kelompok SN (p<0,05). Simpulan: Simvastatin memperbaiki degerasi hidropis dan nekrosis sel hepatosit mencit subtotal nefrektomi.

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“…The I/R procedure was performed after anesthetized with a combination of 90 mg/kg BW ketamine and 10 mg/kb BW xylazine through intraperitoneal injection. (15) Biochemistry Analysis and Body Weight Determinations Blood samples were collected from the retroorbital vein for the determination of blood urea nitrogen (BUN) and creatinine serum (DiaSys, Holzheim, Germany). About 0.5-1 mL blood was centrifuged at a speed of 10,000 rpm for 10 min.…”

Section: I/r Injury Model Of Aki and Experimental Designsmentioning

confidence: 99%

Simvastatin Improves Renal Function and Glomerulosclerosis in Ischemic-reperfusion Injury

et al. 2020

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BACKGROUND: Statin is an anti-cholesterol drug that is widely prescribed throughout the world. Statins are mainly used to treat and prevent cardiovascular disease. Several studies have found the pleiotropic effect of statin. However, related effect of statin in kidney failure is still unclear. Ischemic-reperfusion (I/R) injury is a major cause of acute kidney failure. This study aims to determine the effect of simvastatin on kidney function and glomerular conditions by periodic acid-schiff staining in I/R injury.METHODS: Eighteen male Swiss mice were grouped into sham operation group (GSO), I/R injury group (GIRI), and simvastatin group (GSIM). The GSO group was performed by sham operation and pretreatment of 1% carboxymethylcellulose (CMC) for 3 days. The GIRI group was performed by I/R procedure and pretreatment of 1% CMC for 3 days and the GSIM group was performed by I/R procedure and pretreatment of 10 mg/kg BW simvastatin for 3 days. Blood urea nitrogen (BUN) and creatinine serum were assessed to determine kidney function. Histopathological analysis of glomerulosclerosis was assessed by the extent of glomerular damage (sclerosis), capillary loops, and synechia. The data were analyzed by one-way ANOVA followed by post hoc Tukey’s test (p<0.05).RESULTS: The creatinine and BUN levels in the GIRI group were the highest (0.97±0.48) compared with the other groups. The glomerulosclerosis index in the GSO group was 0.75±0.56, the GIRI group was 3.55±0.61, and the GSIM group was 2.08±1.37. There was a significant difference in the glomerulosclerosis index between the GSO and GIRI groups, but there was no significant difference between the GIRI and GSIM groups. These differences include the formation of sclerosis in the glomerulus, capillary loop, and synechiae.CONCLUSION: Simvastatin improves kidney function and glomerulosclerosis in I/R injury.KEYWORDS: ischemic-reperfusion injury, simvastatin, glomerulosclerosis

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Effect of Simvastatin on Histopathology of the Heart After 5/6 Subtotal Nephrectomy

Cited by 3 publications

References 14 publications

Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice

Simvastatin Significantly Reduced Alcohol-Induced Cardiac Damage in Adolescent Mice

Simvastatin Memperbaiki Degerasi Hidropis dan Nekrosis Sel Hepatosit Mencit Subtotal Nefrektomi

Simvastatin Improves Renal Function and Glomerulosclerosis in Ischemic-reperfusion Injury

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