Effect of Simvastatin and Antioxidant mix on pulpotomized young permanent teeth: A clinical and radiographic study

Abstract

Objective: The objective of this study was to evaluate, clinically and radiographically, the effect of Simvastatin and Antioxidant mix on pulpotomized young permanent teeth. Subjects & Methods: Pulpotomy was performed in 54 vital decayed young permanent molars that were indicated for vital pulp therapy. The molars were classified randomly into three equal groups: Group A: molars receiving Simvastatin after pulpotomy (n=18); Group B: molars receiving Antioxidant mix after pulpotomy (n=18); Group C: molars were receiving calcium hydroxide after pulpotomy (n=18). The treated teeth were followed up clinically and radiographically after variable intervals (immediately, 1 month and 3 months) after treatment. The assessment of treated teeth was performed by visual inspection of the signs and symptoms and by periapical radiographs for assessment of pulp space, lamina dura and periapical tissue. Result: According to pain, mobility, swelling, internal or external resorption, widening of periodontal ligament and periapical radiolucency; in simvastatin group at 3 months, 15 (83.3%) of cases were successful and 3 cases failed. Antioxidant mix, at 3 months, 16 (88.9 %) of cases were successful and 2 cases was failed. Calcium hydroxide, at 3 months, 16 (88.9%) of cases were successful and 2 cases failed. Conclusion: Simvastatin and Antioxidant mix pulpotomy are more costeffective, handled easilily, and biocompatible. It has been proven potentially to be an ideal pulpotomy agent in the treatment of vital young permanent teeth. All three tested materials enhancing root formation "elongation" without significant difference, without any change in periodontal tissue.

Efficacy of Combination of Biodentine and Simvastatin as Pulp Capping Materials in Vital Pulpotomy of Primary Molars: Randomized Clinical Trial

“…In their study of the effectiveness of 3Mixtatin (Simvastatin + 3Mix antibiotic) as a new pulp capping biomaterial in DPC of human primary molars, Aminabadi et al (34) concluded that the radiographic and clinical results of the 3 Mixtatin group showed it to be a good alternative for DPC of primary molar teeth. Moreover, Abd Elmegeid et al (35) concluded that Simvastatin and Antioxidant mix pulpotomy are more cost-effective, handled easily, and biocompatible. It has been shown to have the potential to be an excellent pulpotomy agent when treating young, important permanent teeth.…”

Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review

“…Statin, a hyperlipidaemic drug (3-hydroxy-3-methylglutaryl-coenzyme A). Since they have been used for so long and are the first line of treatment for hyperlipidemia, they are known to be economical and safe [1]. The statins are safe and efficient therapeutics for lowering liver cholesterol production and the production of low-density lipoprotein (LDL) cholesterol, also called bad cholesterol, which is associated with the development of cardiovascular diseases and stroke [2][3][4][5].…”