Effect of simulated rain, coat length and exposure to natural climatic conditions on the efficacy of a topical formulation of eprinomectin against endoparasites of cattle

Efficacy of eprinomectin pour-on treatment in sheep naturally infected withDictyocaulus filariaandCystocaulus ocreatus

“…However, there is considerable evidence that eprinomectin, like ivermectin and moxidectin, is used 'off licence' in these animals (Dupuy et al, 2001). Another advantage of eprinomectin is the ease of drug administration (pour-on), with wool length, timing of rain relative to time of drug application and environmental conditions, such as ultraviolet exposure, heat and freezing, having no effect on the efficacy of treatment (Gogolewski et al, 1997). Another advantage of eprinomectin is the ease of drug administration (pour-on), with wool length, timing of rain relative to time of drug application and environmental conditions, such as ultraviolet exposure, heat and freezing, having no effect on the efficacy of treatment (Gogolewski et al, 1997).…”

An evaluation of the quality and physical properties of calf leather following topical application of eprinomectin

“…It has an extremely high plasma-milk partitioning coefficient, making it suitable for treating all classes of cattle, including lactating dairy cattle (2). Eprinomectin as a topical formulation has excellent efficacy against a wide range of immature and adult parasites in cattle O )(4), and maintains this high efficacy when cattle are exposed to a variety of climatic conditions, including exposure to rain before or after treatment (5).…”

The effects of simulated rain and sun exposure on the plasma disposition of ivermectin following pour‐on administration in heifers

“…, 1999). Similarly, Gogolewski et al. (1997) reported that different climatic conditions such as sunshine, freezing and simulated rain did not affect on the anthelmintic activity of eprinomectin in cattle affected with some nematode species.…”

“…It has been indicated that IVM and doramectin were efficacious against nematodes in cattle following pour-on administration before or after simulated rain (Rolfe et al, 1997;Rehbein et al, 1999;Skogerboe et al, 1999). Similarly, Gogolewski et al (1997) reported that different climatic conditions such as sunshine, freezing and simulated rain did not affect on the anthelmintic activity of eprinomectin in cattle affected with some nematode species. For all that, the present study indicated that the plasma availability and disposition of IVM in heifer after pour-on administration were significantly changed by simulated rain and sun exposure.…”