Effect of Simulated Microgravity and Lunar Gravity on Human Inspiratory Muscle Function: ‘Selena-T’ 2015 Study

Segizbaeva, M. O.; Aleksandrova, N. P.; Donina, Zh. A.; Baranova, E V; Katuntsev, V. P.; Tarasenkov, G. G.; Baranov, V. M.

doi:10.1007/5584_2016_16

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…The aim of the protocol is to study the effect of two different modalities of long-term bed rest space simulations (6 degree HDT bed rest simulating microgravity, and 9.6 degree HUT simulating lunar gravity) on FETa and spirometric indices. It should be mentioned that the current protocol was a part of a multidisciplinary «Selena» Bed Rest Study, some results of which were already published ( Cherepov et al, 2014 ; Segizbaeva et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

A Technique of Forced Expiratory Noise Time Evaluation Provides Distinguishing Human Pulmonary Ventilation Dynamics During Long-Term Head-Down and Head-Up Tilt Bed Rest Tests Simulating Micro and Lunar Gravity

et al. 2018

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Estimating the effect of microgravity/hypogravity on pulmonary ventilation function remains topical. Recently developed acoustic techniques based on the evaluation of the forced expiratory noise time (FETa) were hypothesized to be a promising tool for this aim. The aim of the protocol is to study the effect of two different modalities of bed rest space simulations (microgravity and lunar gravity) on FETa and spirometric indices. The FETa in the frequency band of 200–2000 Hz, recorded above human trachea, was evaluated. The 21st-day exposure to 6 degree head-down tilt (HDT) bed rest, simulating microgravity, and 9.6 degree head-up tilt (HUT) bed rest with head-zero tilt (HZT) rest intervals (HUT + HZT), simulating lunar gravity, in statistically identical subgroups of five and six healthy male volunteers, was studied. In the course of HDT bed rest, a significant elongation of FETa was found in relation to background measurements in “sitting” position (p = 0.016). The effect corresponded to a significant decrease of basic spirometric indices (p < 0.02). Moreover, FETa provided reliable discrimination of HDT and HUT + HZT bed rest tests (p = 0.018), while spirometric indices did not (p > 0.05). Based on previously found correlations (Korenbaum and Pochekutova, 2008; Malaeva et al., 2017), a FETa elongation in response to HDT bed rest was attributed to an increase of aerodynamic resistance of the respiratory tract. The technique seems promising to monitor human pulmonary ventilation dynamics in long-term space missions; however, new studies are welcome to verify it in real spaceflight.

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Section: Introductionmentioning

confidence: 99%

A Technique of Forced Expiratory Noise Time Evaluation Provides Distinguishing Human Pulmonary Ventilation Dynamics During Long-Term Head-Down and Head-Up Tilt Bed Rest Tests Simulating Micro and Lunar Gravity

et al. 2018

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Effects of strict prolonged bed rest on cardiorespiratory fitness: systematic review and meta-analysis

Ried‐Larsen

Aarts

Joyner

2017

Journal of Applied Physiology

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The aim of this systematic review and meta-analysis [International Prospective Register of Systematic Reviews (PROSPERO) CRD42017055619] was to assess the effects of strict prolonged bed rest (without countermeasures) on maximal oxygen uptake (V̇o) and to explore sources of variation therein. Since 1949, 80 studies with a total of 949 participants (>90% men) have been published with data on strict bed rest and V̇o The studies were conducted mainly in young participants [median age (interquartile range) 24.5 (22.4-34.0) yr]. The duration of bed rest ranged from 1 to 90 days. V̇o declined linearly across bed rest duration. No statistical difference in the decline among studies reporting V̇o as l/min (-0.3% per day) compared with studies reporting V̇o normalized to body weight (ml·kg·min; -0.43% per day) was observed. Although both total body weight and lean body mass declined in response to bed rest, we did not see any associations with the decline in V̇o However, 15-26% of the variation in the decline in V̇o was explained by the pre-bed-rest V̇o levels, independent of the duration of bed rest (i.e., higher pre-bed-rest V̇o levels were associated with larger declines in V̇o). Furthermore, the systematic review revealed a gap in the knowledge about the cardiovascular response to extreme physical inactivity, particularly in older subjects and women of any age group. In addition to its relevance to spaceflight, this lack of data has significant translational implications because younger women sometimes undergo prolonged periods of bed rest associated with the complications of pregnancy and the incidence of hospitalization including prolonged periods of bed rest increases with age. Large interindividual responses of maximal oxygen uptake (V̇o) to aerobic exercise training exist. However, less is known about the variability in the response of V̇o to prolonged bed rest. This systematic review and meta-analysis showed that pre-bed-rest V̇o values were inversely associated with the change in V̇o independent of the duration of bed rest. Moreover, we identified a large knowledge gap about the causes of decline in V̇o, particularly in postmenopausal women, which may have clinical implications.

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Effect of Simulated Microgravity and Lunar Gravity on Human Inspiratory Muscle Function: ‘Selena-T’ 2015 Study

Cited by 2 publications

References 18 publications

A Technique of Forced Expiratory Noise Time Evaluation Provides Distinguishing Human Pulmonary Ventilation Dynamics During Long-Term Head-Down and Head-Up Tilt Bed Rest Tests Simulating Micro and Lunar Gravity

A Technique of Forced Expiratory Noise Time Evaluation Provides Distinguishing Human Pulmonary Ventilation Dynamics During Long-Term Head-Down and Head-Up Tilt Bed Rest Tests Simulating Micro and Lunar Gravity

Effects of strict prolonged bed rest on cardiorespiratory fitness: systematic review and meta-analysis

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