Effect of Silymarin and Silibinin-Phosphatidylcholine Complex on Plasma and Lipoprotein Cholesterol, and Oxidation of LDL in Rats Fed on High Cholesterol Diet Supplemented With Currant Oil

Škottová, Nina; Krečman, Vladimı́r; Váňa, Petr; Chmela, Z; Ulrichová, Jitka; Šimánek, Vilı́m

doi:10.5507/bp.2000.019

Cited by 13 publications

(9 citation statements)

References 19 publications

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“…Silymarin also stimulated LDL removal by the liver that contributes to its antihypercholesterolemic effect [151]. Pure silybin but also silybin-phosphatidylcholine complex with better bioavailability [153] was not as effective in cholesterol lowering (ca 50% effectivity) as the silymarin complex suggesting that probably some other components (presumably polymeric fraction) are more efficient. The rats fed standard laboratory diet did not respond to oral administration of silymarin by a decrease of serum cholesterol; indeed, a mild increase of HDL cholesterol was found [152].…”

Section: Silybin As Hypocholesterolemic Agentmentioning

confidence: 99%

Silybin and Silymarin - New and Emerging Applications in Medicine

Gažák¹,

Walterová²,

Křen

2007

CMC

500

309

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This review critically surveys the literature published mainly within this millennium on the new and emerging applications of silybin (pure, chemically defined substance) and silymarin (flavonoid complex from Silybum marianum - milk thistle seeds). These compounds used so far mostly as hepatoprotectants were shown to have other interesting activities, e.g. anticancer and canceroprotective and also hypocholesterolemic activity. These effects were demonstrated in a large variety of illnesses of different organs, e.g. prostate, lungs, CNS, kidneys, pancreas and also in the skin protection. Besides the cytoprotective activity of silybin mediated by its antioxidative and radical-scavenging properties also new functions based on the specific receptor interaction were discovered. These were studied on the molecular level and modulation of various cell-signaling pathways with silybin was disclosed--e.g. NF-kappaB, inhibition of EGFR-MAPK/ERK1/2 signaling, activity upon Rb and E2F proteins, IGF-receptor signaling. Proapoptotic activity of silybin in pre- and/or cancerogenic cells and anti-angiogenic activity of silybin are other important findings that bring silymarin preparations closer to respective application in the cancer treatment. Discovery of the inhibition and modulation of drug transporters, P-glycoproteins, estrogenic receptors, nuclear receptors by silybin and some of its new derivatives contribute further to the better understanding of silybin activity on the molecular level. Silymarin application in veterinary medicine is reviewed as well. Recent works using optically pure silybin diastereomers clearly indicate extreme importance of the use of optically active silybin namely in the receptor studies. Significance of silymarin and its components in the medicine is clearly indicated by an exponential growth of publications on this topic--over 800 papers in the last 5 years.

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Section: Silybin As Hypocholesterolemic Agentmentioning

confidence: 99%

Silybin and Silymarin - New and Emerging Applications in Medicine

Gažák¹,

Walterová²,

Křen

2007

CMC

500

309

View full text Add to dashboard Cite

show abstract

“…[44,46] The effects of silymarin on plasma triglycerides, VLDL, LDL, and high density lipoproteins (HDL) has been evaluated. It lowers plasma VLDL [42][43][44] but has no effect on plasma LDL. [42,44] Silymarin and silibinin increase HDL.…”

Section: Antilipidemic Effectsmentioning

confidence: 97%

“…[42,43] However, silymarin in combination with other milk thistle flavonoids decreased cholesterol absorption from the small intestine in rats fed a high fat diet, through an action similar to bile-acid sequestrants. Taxifolin, a flavonoid compound found in milk thistle, has also been found to inhibit cholesterol absorption.…”

Section: Antilipidemic Effectsmentioning

confidence: 98%

“…[42,44] The mechanisms through which silymarin may exert these effects is unknown, but its antioxidant properties may be responsible for inhibition of LDL oxidation. [43] Anticancer Effects…”

Section: Antilipidemic Effectsmentioning

confidence: 99%

“…Silibinin inhibits 3-hydroxy-3-methylglutaryl-CoA (HMG-COA) reductase activity in a dose-dependent manner in cell lines, but this has not been observed in rat liver microsomes. [45] Silymarin decreases the concentration of cholesterol in very low density lipoproteins (VLDL), [41,43,44] but its effect on plasma cholesterol levels is uncertain. An inverse relationship between plasma cholesterol levels and silymarin was seen in one study, [42] but another study has not found an association.…”

Section: Antilipidemic Effectsmentioning

confidence: 99%

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