Effect of silver nanoparticles on some blood parameters in rats

Abstract

The present study aims are investigating the effects of oral administration of AgNPs on some blood the parameters to show potential of toxicity of AgNPs as tool therapy and diagnosis. In this study, 20 healthy male and female rats were used. Randomly, rats were divided into 5 groups depending on the period variable respectively; AgNPs-treated rats' groups for a period of 3 days in concentration 0.2 and 0.4 gm/kg B.W, while the second period after 20 and 30 days after treatment with concentration 0.08 and 0.008 gm/ kg B.W. In addition to a control group. A Manual method was used to measure Hematological parameters. Rats treated with AgNPs showed the significant P<0.05 decrease in Hemoglobin, Packed Cell Volume, Red Blood Cells. Also, Mean Corpuscular Volume; Mean Corpuscular Hb and Mean Corpuscular Hb Concentration. Platelets levels and White Blood Cell Count were After the administration of AgNPs, a protective effect on hematopoietic levels and on Red Blood Cell morphology were shown respectively as it is assessed by Leishman stained blood smears resulted in ovalocytosis at the dose 0.4 gm/kg body weight, while at the dose, 0.08 gm/kg showed echinocytes, acanthocytes, tear drop, stomatocyte and codocyte (target RBCs). Thus, it is concluded that oral administration of AgNPs caused a decreased in the level of Hb concentration, PCV, RBC, MCV, MCH, MCHC, but increase PLTS and WBCs. It means that AgNPs has a toxic effect on blood.

Toxic effects of butylated hydroxytoluene in rats

“…The histopathological changes of the lungs showed sloughing of epithelial lining the bronchi bronchopneumonia, edema, emphysema, and fibrinous edema that result agreement with another study which found that acute pulmonary toxicity and tumor promotion by the food additive 2,6-di-tert-butyl-4-methylphenol (BHT) are well documented to cause lung lesions (27,28). These suggest the possibility that BHT may exert their promoting effects by inducing oxidative stress, normal cells are destroyed more readily which allows neoplastic cells to expand their proliferation (29,30). Our interpretation for that is the high doses or reheated of BHT are produce lung damage due to some BHT metabolites that are conjunction with SH-groups for proteins like cysteine protein and also inhibit glutathione formation that causes lung toxicity.…”

Evaluation of Scrophularia striata Hydroalcoholic Extract's Hematomodulatory Effects: An Approach to Traditional Ethnomedicine

“…In this study, RBC and HGB levels increased and afterwards increase of HCT, MCV, MCH and MCHC levels were observed in three treatments groups (A, B & C) in comparison with the PC groups. The results of the present study correlate with several reports on the hematotoxic of AgNPs (50,51), and this results were consistent with the Rostami, and Mahdavi on hemathomomodulatory effects of Scrophularia striata studies (37,38).…”

Acute enzootic muscular dystrophy of adult lambs at Basrah, Iraq

“…In this study, the levels of vitamin E and selenium were clearly decreased in diseased animals compared with the control group. Vitamin E is considered the main and important antioxidant factor in the body, nevertheless, not all its characterizations could be detected in this action and its main activities are confined to act in cell membranes to prohibit the spreading of free radical interactions and reactions, although it has been also indicated to have prooxidant activities (17,18). On the other hand, it was shown that the non-radical oxidation products could be created through the reaction between alpha-tocopheryl radical and the other free radicals, which are together with glucuronic acid and excreted through both bile and urine.…”