Effect of silver nanoparticles alone and in combination with fluconazole on Candida albicans

Alshaikh, Najla A.; Perveen, Kahkashan; Bahkali, Ali H.

doi:10.1016/j.jksus.2022.102399

Cited by 9 publications

(6 citation statements)

References 27 publications

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“…To the best of our knowledge, this is the first report on the inhibition of germ tube formation by biogenic SnO 2 NPs. Our results are in accordance with those reported with nanoparticles of silver and zinc oxide where notable reduction of 95% and 86.4% in germ tube formation was observed ( Jalal et al., 2018 ; Alshaikh et al., 2023 ).…”

Section: Resultssupporting

confidence: 93%

In vitro inhibition of biofilm and virulence factor production in azole-resistant strains of Candida albicans isolated from diabetic foot by Artemisia vulgaris stabilized tin (IV) oxide nanoparticles

Zubair,

Husain,

Al-Amri

et al. 2024

Front. Cell. Infect. Microbiol.

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The advent of nanotechnology has been instrumental in the development of new drugs with novel targets. Recently, metallic nanoparticles have emerged as potential candidates to combat the threat of drug-resistant infections. Diabetic foot ulcers (DFUs) are one of the dreadful complications of diabetes mellitus due to the colonization of numerous drug-resistant pathogenic microbes leading to biofilm formation. Biofilms are difficult to treat due to limited penetration and non-specificity of drugs. Therefore, in the current investigation, SnO2 nanoparticles were biosynthesized using Artemisia vulgaris (AvTO-NPs) as a stabilizing agent and were characterized using ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). Furthermore, the efficacy of AvTO-NPs against biofilms and virulence factors of drug-resistant Candida albicans strains isolated from DFUs was assessed. AvTO-NPs displayed minimum inhibitory concentrations (MICs) ranging from 1 mg/mL to 2 mg/mL against four strains of C. albicans. AvTO-NPs significantly inhibited biofilm formation by 54.8%–87%, germ tube formation by 72%–90%, cell surface hydrophobicity by 68.2%–82.8%, and exopolysaccharide (EPS) production by 69%–86.3% in the test strains at respective 1/2xMIC. Biosynthesized NPs were effective in disrupting established mature biofilms of test strains significantly. Elevated levels of reactive oxygen species (ROS) generation in the AvTO-NPs-treated C. albicans could be the possible cause of cell death leading to biofilm inhibition. The useful insights of the present study could be exploited in the current line of treatment to mitigate the threat of biofilm-related persistent DFUs and expedite wound healing.

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Section: Resultssupporting

confidence: 93%

In vitro inhibition of biofilm and virulence factor production in azole-resistant strains of Candida albicans isolated from diabetic foot by Artemisia vulgaris stabilized tin (IV) oxide nanoparticles

Zubair,

Husain,

Al-Amri

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Combined antimicrobial interactions were classified with the following parameters: when the FIC index was 0.5, the interactions were synergistic; when the FIC index was between 0.5 and 4, the interactions were indifferent; and when the FIC index was greater than 4, the interactions were antagonistic [ 31 ]. The FIC of each material used in the present study is shown in Table S2 .…”

Section: Resultsmentioning

confidence: 99%

Green synthesis of copper ions nanoparticles functionalized with rhamnolipid as potential antibacterial agent for pathogenic bacteria

Habibah,

Sri Rizki,

Ivansyah

et al. 2024

Heliyon

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“…They can both inhibit the growth of yeast cells and influence various virulence factors, e.g., biofilm formation. The antifungal activity of AgNPs against C. albicans was investigated by Alshaikh et al [27]. AgNPs were coated with polyvinylpyrrolidone (PVP) for water dispersion.…”

Section: Antifungal Activity Of Silver Nanoparticles Against Candida ...mentioning

confidence: 99%

Antifungal Activity against Human and Plant Mycopathogens, and Green Synthesis of Silver Nanoparticles Exhibiting Such Activity

Górka,

Kubiński

2023

Applied Sciences

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Silver nanoparticles have long been known for their antibacterial properties. Recently, increasing numbers of studies confirm that they have antifungal properties as well. Due to the increasing number of these studies, this review was performed, summarizing most of the research conducted so far in this field and presenting the results of the activity of silver nanoparticles against fungal pathogens of humans and plants, green synthesis of silver nanoparticles, and the mechanism of action. The combined activity with antifungal drugs and toxicity assessment is also presented. The review describes the antifungal activity of silver nanoparticles against pathogens such as F. oxysporum, F. graminearum, T. asahii, B. cinerea, P. concavum, and Pestalotia sp. as well as many species of the genus Candida. The green synthesis of these nanoparticles has been carried out from many species of plants and microorganisms. The research cited in this review confirms the fact that silver nanoparticles obtained using green synthesis exhibit antifungal activity and can therefore be an excellent alternative to the chemical synthesis of these particles. All this proves that silver nanoparticles have a great potential to be used as a potential antifungal agent in the future.

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Effect of silver nanoparticles alone and in combination with fluconazole on Candida albicans

Cited by 9 publications

References 27 publications

In vitro inhibition of biofilm and virulence factor production in azole-resistant strains of Candida albicans isolated from diabetic foot by Artemisia vulgaris stabilized tin (IV) oxide nanoparticles

In vitro inhibition of biofilm and virulence factor production in azole-resistant strains of Candida albicans isolated from diabetic foot by Artemisia vulgaris stabilized tin (IV) oxide nanoparticles

Green synthesis of copper ions nanoparticles functionalized with rhamnolipid as potential antibacterial agent for pathogenic bacteria

Antifungal Activity against Human and Plant Mycopathogens, and Green Synthesis of Silver Nanoparticles Exhibiting Such Activity

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