Effect of Silver Nanoparticle Administration on Productive Performance, Blood Parameters, Antioxidative Status, and Silver Residues in Growing Rabbits under Hot Climate

Abstract

Simple SummarySilver nanoparticles (AgNPs) were used for their antibacterial effects, which increase productive performance and immune response in poultry and rabbits. On the other hand, residues of silver in meat and the internal organs of treated animals may be toxic for human beings. The current results of using two doses of injecting AgNPs revealed that body weight significantly improved in rabbits given a low dose of AgNPs compared with control animals. For consumers’ health concerns, it is of interest to note that the amount of accumulated silver in blood plasma and meat increased dramatically with an increasing dose.AbstractThe influence of subcutaneous injections of silver nanoparticles (AgNPs) on rabbit performance, hematological and biochemical parameters of blood, antioxidant status, and the residues of silver in meat and blood in two breeds (New Zealand White (NZW) and Jabali) of rabbits growing under high ambient temperature was evaluated. A total of 90 six-week-old rabbits (45 NZW and 45 Jabali) were randomly distributed into three equal treatment groups (control, 0.5 mg, and 1.0 mg AgNPs/kg body weight). The treated rabbits were injected twice a week for four consecutive weeks. The results revealed that AgNPs administration had no significant effect on average daily gain (ADG), feed intake, and feed conversion ratio (FCR). The NZW breed surpassed the Jabali breed in growth performance traits, carcass weight, dressing percentage, and cuts of mid parts and hind cuts. Administration of AgNPs had a significant effect on hematocrit (HCT) and platelet (PLT) values. Rabbits injected with AgNPs at a dose of 0.5 mg showed a lower plasma concentration of total cholesterol and triglycerides than that of control rabbits. The NZW breed had significantly low platelet, total cholesterol, and triglyceride values. Rabbits injected with 0.5 mg/kg BW had the lowest total antioxidant capacity and highest malondialdehyde (MDA) and glutathione peroxidase. The Ag residues were higher in blood than those in meat in treated rabbits. The local breed (Jabali) had significantly lower residues than the imported one (NZW) either in meat or in blood. However, the amount of accumulated silver in blood plasma and meat increased with increasing dose.

Solid-state Synthesis of Silver-silica Nanoparticles Mediated Starch as a Dietery Supplement in Poultry; Genotoxic, Immunologic and Immunohistopathologic Charecterization

“…The decrease in cumulative body weight and other relative organ weights such as spleen of boiler chickens supplemented with SiO2@AgNPs might be due to the effect of these nanomaterials on blocking the intestinal absorption of actively transported sugars and amino acids, and reduced protein digestibility through the small intestine where mainly enzymatic activity is present as maintained by Vadalasetty et al (2018) 23 . From current results It can be noticed that the levels of SiO2@AgNPs levels had significant and insignificant effect on some parts of carcass, for instance the spleen percentages was decreased comparing with control group (p > 0.05), Bursa (not significant effect) and Thymus showed significant effect (p > 0.008), these results were partially agreeing with Abdelsalam et al (2019) 55 . Administration of SiO2@AgNPs showed a substantial and insignificant effect in all blood parameters values as found in (Table 3).…”

Breed Effects on Growth Performance, Blood Parameters and the Levels of Metabolic Hormones in Rabbits Under Heat Stress in Egypt

“…The higher growth performance traits (body weight, ADG, ADFI and feed to gain ratio) that have been depicted by exotic breeds (NZW and Rex) compared with local Egyptian breeds (Al-Gabali) were detected in a previous most recent study [41], and this showed the genetic potential of these breeds for growth compared with Egyptian local breed..…”

“…Concerning the results of oxidative stress parameters, the current results collaborate those of Abdel-Hamid and Omar [51], who detected significant effect of genetic group on catalase separately and GPx in interaction with dietary supplementation with formic acid under heat stress (32°C ± 1). There were nonsignificant effects of breed on TAC, GPx, and malondialdehyde under heat stress [41]. The oxidative stress indicators were recorded in the serum of four exotic rabbit breeds (Fauve de Bourgogne, Chinchilla, British Spot, and New Zealand White) in Ibadan, Southwest Nigeria within July and August, and it was found that the four breeds had similar (P >0.05) serum lipid peroxidation, TAC, catalase, and GPx, whilst British Spot rabbits had a high significant (P <0.05) SOD, which suggests that this breed had the least superoxide anion scavenging ability compared with other breeds [52].…”

“…It is possible to explain these controversial results to the difference in temperatures at which these experiments were conducted. Differences between NZW and Al-Gabali had not been detected for hematological and biochemical parameters except for platelet (P =0.04), Al-Gabali was higher than NZW under Al-Qassim, Saudi Arabia environmental conditions (33 °C ± 0.6) [41]. In another study included two genetics groups (V-line and V-line × Gabali), it was found that these two genotypes were similar in all blood parameters except for cholesterol, total lipids and triglycerides [47] [12].…”

Beneficial effects of curcumin as a native or nanoparticles form on productive efficiency, liver and kidney functions, antioxidative status and immunity of heat‐stressed growing rabbits

“…The antioxidants play an important action as protector's cells from ROS production via reducing the free radicals and disrupting the process of lipid peroxidation (Rahmani, Goliana, Kermanshahia, & Bassamib, 2018). Usage of synthetic antioxidants (vitamins and minerals) or natural antioxidants (herbs and spices) is commercially accepted, as a strategy for improving the productivity and health status of heat‐stressed rabbits (Abdelsalam et al., 2019; Daader et al., 2018).…”