Effect of silibinin on telomerase gene expression in breast cancer cell line (T47D)

Nasiri, Marzieh; Zarghami, Nosratollah; Pourhassan‐Moghaddam, Mohammad; Rahmati, Mohammad; Nejati-Koshki, Kazem; Mollazadeh, Mahdieh; Jahanban, Raana; Barkhordari, Amin

doi:10.1016/j.clinbiochem.2011.08.1052

Cited by 1 publication

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“…T47D breast cancer cell line was treated with Silibinin+CCM mixture. This mixture has an inhibitory effect on hTERT gene expression in a dose-dependent manner and the real-time PCR results show a significant decrease in hTERT expression [35].…”

Section: Silymarin Interaction With Proactive Compounds From Plantsmentioning

confidence: 86%

Interaction of Bioactive Compounds With Ceramic Materials – A Review

PALTINEAN¹,

Tomoaia²,

RACZ³

et al. 2022

AnnalsARSciPhysChem

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This review examines the interaction between silymarin (SIL) and other plant-based bioactive compounds such as curcumin (CCM), piperine (PIP), resveratrol (RES), and icariin (ICA). Their combination revealed synergistic effects on colon (HCT116), breast (T47D) tumor cells, hepatocellular carcinoma, and periodontal disease. The review also addresses the interaction between these plant extracts with ceramic materials such as hydroxyapatite (HAP) and carotenoids with concrete examples of biomedical applications. Silymarin’s interaction with chemotherapeutic drugs (doxorubicin-DOX, paclitaxel-PCT and 5-Fluorouracil-5-FLU) and gold nanoparticles-GNPs and silver nanoparticles-SNPs is also debated. All these combinations can form composites of major importance in the biomedical field and to contribute significantly to orthopedic surgery where materials are needed for implants that face severe infections. This short review highlights the variety of multifunctional nanoparticles that open new opportunities in cancer treatment and the need to use the Langmuir Blodgett Technique that mimics the biological membrane and provides rich medical information.

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Section: Silymarin Interaction With Proactive Compounds From Plantsmentioning

confidence: 86%