Effect of sildenafil on wound healing: an experimental study

Derıcı, Hayrullah; Kamer, Erdinç; Ünalp, Haluk Recai; Dınız, Gülden; Bozdağ, Ali Doğan; Tansuğ, Tuğrul; Ortaç, Ragıp; Erbil, Yeşim

doi:10.1007/s00423-009-0471-2

Cited by 35 publications

(35 citation statements)

References 25 publications

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“…The decreased blood glucose and increased red blood cells count observed during the 21 days treatment may be due to the action of sildenafil citrate in the inhibition of cGMP degradation (Gross, 2005;Hamed et al, 2010) and may be an indication that sildenafil citrate improves insulin mediated glucose pathways and reduce blood glucose and increase red blood cells count (Hamed et al, 2010;Das et al, 2012). This supports the findings of Derici et al (2010) which states that, sildenafil citrate, a specific inhibitor of cyclic guanylate monophosphate phosphodiesterase type 5 (PDE5) is known to stimulate the release of nitric oxide, that plays an important role in wound healing involving oxidative stress by reactive oxygen species. However, it is recommended that further studies should be carried out in this field of research using lower dosages of sildenafil citrate administered through the systemic route for a longer period of time.…”

Section: Discussionsupporting

confidence: 81%

“…Treatment with sildenafil citrate orally at the dose rate of 50 mg/kg has no effect on hemoglobin concentration, packed cell volume, mean corpuscular hemoglobin concentration and mean corpuscular volume. Sildenafil citrate, a specific inhibitor of cyclic guanylate monophosphate phosphodiesterase type 5 (PDE5) known to stimulate release of nitric oxide, that plays an important role in wound healing involving oxidative stress by reactive oxygen species (Derici et al, 2010). However, at high concentration, sildenafil citrate adversely affects the red blood cells membrane architecture and cellular mechanical behavior (Jin et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Haematological changes and wound healing effects of sildenafil citrate in diabetic albino rats

Mahre¹,

Umaru²,

Ngulde³

et al. 2017

Sokoto J. Vet. Sc.

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This study presents baseline data on the effect of sildenafil citrate on some of the haematological and biochemical parameters in wistar rats with diabetes and wound formation. Forty two albino rats weighing between 139 and 225 g were separated at random into seven groups (A, B, C, D, E, F and G) of six rats per group. Type 1 diabetes mellitus was induced in groups A, B, C and D by a single intra-peritoneal injection of 130 mg/kg Alloxan. Rats in group A were treated with orally dose of 50 mg/kg sildenafil citrate for 21 days and rats in group B were administered 10 IU of insulin intramuscularly once and sildenafil citrate as in Group A. The rats in group C were treated with a single dose of 10 IU of insulin intramuscularly, and rats in group D with only distilled water. Groups E and F were normal rats with wounds similar to those of diabetic rats in the previous groups and each rat in group E was also treated with sildenafil citrate as in Group A and those in group F were treated with only distilled water. Group G were normal rats without wound treated with sildenafil citrate as in Group A. Blood samples were taken before (day 0) and after the administration of the sildenafil citrate on day 7, 14 and 21. The results of the study showed significant decreased in red blood cells count from 6.28 ± 0.46 × 10 6 to 2.81 ± 0.46 × 10 6 in diabetic rats during the 14 days of treatment with sildenafil citrate, however, there was an indication that continues treatment for up to 21 days reduced the blood glucose and increased the red blood cells count and this may be an indication that sildenafil citrate improves insulin mediated glucose pathways.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Haematological changes and wound healing effects of sildenafil citrate in diabetic albino rats

Mahre¹,

Umaru²,

Ngulde³

et al. 2017

Sokoto J. Vet. Sc.

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“…In the study of wound healing activity of neomycinGhee Combination, the wounds were biopsied on day 10 ( Atiyeh et al, 2002), so the author decided to do wound biopsy on days 9 and 21. Derici et al (2010) showed in their study that the neovascularization score of the wounds treated with sildenafil was 1.5 on the 7th day while the control group had a score of 1.0. Neovascularization was higher in the intervention group on the 21st day (1.7 against 1.0).…”

Section: Discussionmentioning

confidence: 97%

Albusite: A Novel Synthetic Gel for Promotion of Skin Wound Healing in Rats

Jahanabadi¹,

Karami²,

Paydar³

et al. 2015

OnLine Journal of Biological Sciences

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The current study was performed to evaluate the effect of Albusite gel on the healing process of excisional wounds in diabetic and control rats. Fifty-two Sprague Dawley male rats were used to evaluate the effects of Albusite Gel (synthetic gel) on the healing of full-thickness skin wounds. The control group (n = 2 6) and study group (n = 26) were divided into two groups (n = 13). Wounds were assessed by wound measurements and collection of samples at 9 (A, C) and 21 days (B, D) post-wounding to evaluate the healing process. Variables of interest were gross and microscopic histopathological characteristics were reflective of wound healing. Topical Albusite gel was applied for wound A and B, once a day. Each rat was anesthetized and a round full thickness excisional wound with 150 cm 2 area was performed on the right dorsolateral side of each rat. There was little difference between the case and control groups. Wound healing processes and wound closure in the intervention group began sooner and completed more quickly respectively, but both of them did not show a statistically significant difference (p>0.05). The healing of Albusite treated wound was better than the control wounds grossly. The study wounds were biopsied at days 9 and 21, so this might not show different effects of the Albusite gel group in appropriate time. Therefore, further studies are recommended with more sample size and less biopsy interval.

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“…The oral dose was described as 1 mg/kg/ day -20 mg/kg/ day depending on each specifi c case. We chose to apply it 5 mg/kg/ day by orogastric lavage, which has been proven to be effective in studies (15).…”

Section: Discussionmentioning

confidence: 99%

“…It has been recently reported by Derici et al, the useful effects of sildenafi l on abdominal wall healing (15). Hypothesis driven studies in both animals and human subjects indicated that NO infl uences wound healing at a number of levels including angiogenesis, infl ammatory cell proliferation, matrix deposition and remodelling.…”

mentioning

confidence: 91%

Effect of sildenafil citrate on secondary healing in full thickness skin defects in experiment

Çakmak¹,

Yeşilada²,

Sevim³

et al. 2014

BLL

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Abstract:Objectives: An acceleration of the wound healing process expedites chronic wound patient's return to normal social environments signifi cantly. Sildenafi l, a cyclic guanosine monophosphate (cGMP)-dependent phosphodiesterase-5 inhibitor has been shown to be a potent stimulator of angiogenesis through upregulation of cGMP. In our study, sildenafi l was administered orally as a cost-effective supplement in the treatment of full thickness defects and chronic wounds in that manner with low incidence of side effects and morbidity. Materials and methods: Randomly selected 72 Wistar-Albino rats were divided into the two groups, 36 rats in each group. Control group (n =36) was divided further into a secondary healing group consisting of 9 rats and a pathology group consisting of 27 rats (pathology group 1: 9 rats, 4th and 7th day of wound healing, pathology group 2: 9 rats, 10th and 14th day of wound healing, pathology group 3: 9 rats, 21st and 28th day of wound healing. Experimental group consisted of 36 rats which received sildenafi l citrate (Viagra® Pfi zer, Germany) for secondary wound healing to proceed. Results: The average wound healing period in the control group was 17.89 days and in the sildenafi l citrate administered group 14.56 days. The difference of the epithelialisation on full thickness defects were more prominent on days 5 and 11 postoperatively. In the sildenafi l citrate applied group, on the 7th day, the defect was 25 % smaller and on the 13th day, the defect contracted by 38 %. Conclusion: In conclusion, we believe that sildenafi l citrate administered orally is a cost-effective supplement in the treatment of full thickness defects and chronic wounds in that manner with low incidence of side effects and morbidity (Tab. 4, Fig. 7, Ref. 34). Text in PDF www.elis.sk.

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Effect of sildenafil on wound healing: an experimental study

Abstract: Sildenafil can be used as a supporting factor in wound healing.

Cited by 35 publications

References 25 publications

Haematological changes and wound healing effects of sildenafil citrate in diabetic albino rats

Haematological changes and wound healing effects of sildenafil citrate in diabetic albino rats

Albusite: A Novel Synthetic Gel for Promotion of Skin Wound Healing in Rats

Effect of sildenafil citrate on secondary healing in full thickness skin defects in experiment

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