Effect of sildenafil citrate on the liver structure and function in obstructive jaundice: An experimental study

Simsek, Tamer; Ersoy, Ömer Faik; Özsoy, Zeki; Yenidoğan, Erdinç; Kayaoğlu, Hüseyin Ayhan; Özkan, Nilüfer; Şahi̇n, Mustafa

doi:10.5152/turkjsurg.2018.3771

Cited by 13 publications

(12 citation statements)

References 23 publications

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“…Sildenafil is a phosphodiesterase type 5 enzyme inhibitor. Inhibition of this enzyme increases the cyclic guanosine monophosphate levels inside cells and the NO concentration in the surrounding environment, which in turn leads to vascular smooth muscle relaxation, vasodilatation, inhibition of platelet aggregation, an increased blood flow, stimulation of angiogenesis and a decreased severity of inflammatory reactions 4,41,42 .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Sildenafil and/or Nitroglycerin on Random-pattern Skin Flaps After Nicotine Application in Rats

Ellabban

Fattah

Kader

et al. 2020

Sci Rep

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Smoking aggravates skin necrosis as a complication of random-pattern flap ischaemia. Sildenafil and nitroglycerin (NTG) are vasodilator agents that may affect skin flap survival. Fifty rats were subjected to a dorsal random-pattern flap operation and randomly divided into 5 groups. The control group received no treatment. The ischaemic group were administered local nicotine injections. The sildenafil group were administered oral sildenafil treatment in addition to the same intervention as the ischaemic group. The NTG group received topical NTG ointment application instead of sildenafil. The combined group were given both sildenafil and NTG treatments. After 7 days, all rats were sacrificed for flap assessment. Flap survival percentages at the 3 rd and 7 th days were significantly higher in the combined group than in the other study groups. Histologically, the ischaemic group exhibited dermal disorganization and inflammatory cell infiltration, which were improved in the 3 treated groups; however, the combined group presented the most relevant effect. The epidermal thickness showed a decrease in the ischaemic group (23.1 μm) that was significantly increased in the sildenafil (28.4 μm), NTG (28.8 μm) and combined (35.8 μm) groups. Immunohistochemically, the combined group exhibited a significant decrease in the apoptotic index and an increase in the proliferative index (2.3 and 56.9%, respectively) compared to those in the ischaemic (63.2 and 3%), sildenafil (41.7 and 28.1%) and NTG (39.3 and 30.4%) groups. Transmission electron microscopy (TEM) showed that the combined group displayed improvement in most of the ischaemic changes. Our analyses suggest that the combined use of sildenafil and NTG is more efficacious than using only one of these treatments for skin flap survival.Random skin flaps are widely used options for the reconstruction of large acquired or congenital skin defects 1 . Survival of these flaps is highly reliant on oxygen delivery to their tissues 2 . The main challenge is that the distal parts of the flap suffer from a reduced blood supply, which can trigger skin necrosis 3 . This reduction in the blood supply is mainly caused by anatomical or haemodynamic factors 4 . During vascular regeneration, ischaemia/reperfusion injury occurs, promoting oxidative stress and apoptosis 3 . Additionally, other factors, such as inadequate angiogenesis and inflammatory reactions, play roles in the pathogenesis of flap necrosis 5 .Skin flap ischaemic necrosis and increased incidence of infection can be aggravated by nicotine, which endangers the results of plastic skin reconstruction 6 . Smoking increases the risk of skin flap complications, which has been observed in clinical and experimental studies in both rats and hamsters 7 . Smokers have a higher risk of developing skin flap necrosis, namely, 13 times higher than that of non-smokers, which can result in flap loss or secondary contractures that negatively affect the aesthetic outcomes 6,8 . The potential mechanisms of this increased risk in smokers are highly...

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Section: Discussionmentioning

confidence: 99%

The Effects of Sildenafil and/or Nitroglycerin on Random-pattern Skin Flaps After Nicotine Application in Rats

Ellabban

Fattah

Kader

et al. 2020

Sci Rep

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“…Liver function tests did not changed significantly between the 10th and 28th day in sildenafil-treated rats (p>0.05). The sildenafil-treated groups at different time points didn't show any statistical difference in histopathological changes (p>0.05) [16].…”

Section: Discussionmentioning

confidence: 86%

“…At the 28th day, liver function tests except alanine aminotransferase showed statistical significant differences among the groups (p<0.001). Liver function tests did not show statistical significant changes between the 10th and 28th day in sildenafil-treated rats (p>0.05) [16].…”

Section: Effects Of Sildenafil Citrate On Some Major Organs Of the Albino Ratmentioning

confidence: 78%

“…The difference noted with the 100mg/kg treatment group may be from the higher dose of 100mg/kg body weight of sildenafil citrate and the fact that the male Wister albino rats were induced with obstructive jaundice by legating their common bile ducts which was not the practice in this index study. This cited study concluded that oral administration of 10 mg/kg sildenafil citrate dramatically reversed the biochemical and histopathological liver changes induced by obstructive jaundice in rats [16]. The findings of the index study also compared with those of another research in which it was reported that the use of high doses of sildenafil citrate or its misuse could lead to serious histopathological malformations.…”

Section: Discussionmentioning

confidence: 90%

“…On the 28th day, the severity of structural changes in the liver after obstructive jaundice, except edema, reduced significantly (p<0.001). The sildenafil-treated groups at different time points didn't show any statistical difference in histopathological changes (p>0.05) [16].…”

Section: Effects Of Sildenafil Citrate On Some Major Organs Of the Albino Ratmentioning

confidence: 86%

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A scientific compendium of the effects of sildenafil citrate on the liver, kidney and heart of male albino rats at Nnewi, South East Nigeria

Se¹,

Unekwe²,

Lc³

et al. 2020

World J. Bio. Pharm. Health Sci.

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This study investigated the various effects of Sildenafil citrate on the liver, kidney and heart of male albino rats. Twenty eight male rats randomly divided into 4 groups and weighing 131-214g were used. While the animals in group 1 (control) received food and water only, those in the study groups 2,3&4 respectively received 25mg/kg, 50mg/kg and 100mg/kg of Sildenafil citrate orally, daily for 4 weeks. All animals were sacrificed and blood samples collected by cardiac puncture for analysis of biochemical parameters. The rats Liver, kidneys and hearts were subjected to histopathological tests. Study results showed no changes in food consumption, fluid intake, body weight and relative organ weight of the animals. The animals in group 4 showed significant increase in mean Lactate dehydrogenase and Aspartate aminotransferase ⃰(P<0.05) compared to control. Mean levels of creatinine was significantly higher among group 4 animals ⃰(p<0.05) but not significantly high among the animals in other groups. Mean Na+ and Cl- level were significantly high among the animals in group 4 ⃰(p<0.05). Although no histopathological changes were observed in the heart of the rats in groups 2,3 and 4, there were significant increase in serum levels of Na+, K and Cl- of animals in group 4 which could have affected their heart owing to fatigue. Sildenafil citrate (100mg/kg) caused distortion in cyto-architecture of the liver and mild distortion of cortical structures in the kidneys of albino rats. Sildenafil citrate has potential toxic effects on the liver, kidney and heart of studied rats with higher doses. Conclusion: Sildenafil citrate has potential toxic effects on the liver, kidney and heart of male albino rats especially with higher doses.

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Impact of sildenafil-containing ointment on wound healing in healthy and experimental diabetic rats

2020

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Effect of sildenafil citrate on the liver structure and function in obstructive jaundice: An experimental study

Cited by 13 publications

References 23 publications

The Effects of Sildenafil and/or Nitroglycerin on Random-pattern Skin Flaps After Nicotine Application in Rats

The Effects of Sildenafil and/or Nitroglycerin on Random-pattern Skin Flaps After Nicotine Application in Rats

A scientific compendium of the effects of sildenafil citrate on the liver, kidney and heart of male albino rats at Nnewi, South East Nigeria

Impact of sildenafil-containing ointment on wound healing in healthy and experimental diabetic rats

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