Effect of short-time malathion administration on glucose homeostasis in Wistar rat

Lasram, Mohamed Montassar; Annabi, Alya; Rezg, Raja; Elj, Naziha El; Selmi, Slimen; Kamoun, A; El-Fazaâ, Saloua; Gharbi, N.

doi:10.1016/j.pestbp.2008.06.006

Cited by 54 publications

(38 citation statements)

References 43 publications

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“…Acute exposure of rats to malathion resulted in hyperglycemia with peak increase occurring at 2.2h after administration followed by decrease after 4h (Rodrigues et al, 1986). A similar case of reversible hyperglycemia has been reported by Lasram et al, (2008) following administration of a single dose of malathion to rats. Biochemical changes associated with hyperglycemia serve as useful tools to understand etiology of OPI-induced hyperglycemia.…”

Section: Organophosphorus Insecticides and Glucose Homeostasis: Mechasupporting

confidence: 62%

“…Malathion induced hyperglycemia was associated with AChE inhibition in pancreas. More importantly, the trend of reversibility coincided with spontaneous reactivation of inhibited AChE (Lasram et al, 2008), indicating involvement of AChE-inhibition in hyperglycemia. Increase in blood glucose induced by sub chronic exposure of rats to malathion has been reported to be associated with increased glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities, indicating involvement of both glycogenolytic and gluconeogenic processes.…”

Section: Organophosphorus Insecticides and Glucose Homeostasis: Mechamentioning

confidence: 84%

“…This trend observed in the present study is consistent with other reports, which demonstrated reversible hyperglycemia in experimental animals following OPI administration. While Malathion has been reported to cause reversible hyperglycemia in rats (Gupta, 1974;Rodrigues et al, 1986;Seifert, 2001;Lasram et al, 2008), acute exposure to diazinon induced reversible hyperglycemia in mice (Seifert, 2001). Based on the above results, we reasoned that the reversible hyperglycemia could be triggered by transient changes in the hormonal milieu of glucose homeostasis.…”

Section: Adrenal Involvementmentioning

confidence: 85%

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Organophosphorus Insecticides and Glucose Homeostasis

Joshi¹,

Rajini²

2012

Insecticides - Pest Engineering

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Section: Organophosphorus Insecticides and Glucose Homeostasis: Mechasupporting

confidence: 62%

Section: Organophosphorus Insecticides and Glucose Homeostasis: Mechamentioning

confidence: 84%

Section: Adrenal Involvementmentioning

confidence: 85%

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Organophosphorus Insecticides and Glucose Homeostasis

Joshi¹,

Rajini²

2012

Insecticides - Pest Engineering

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“…Extensive studies have been conducted for assessing the potential health effects of malathion in a variety of biological models from amphibians to mammalians. It has been reported that malathion induces toxicity through the inhibition of acetylcholinesterase (AchE) and subsequent activation of cholinergic receptors [Lasram et al, 2008]. Animal study suggested that inhibition of enzymes leads to age-dependent neurologically disorders neurological and behaviour disorders [Vidair, 2004].…”

Section: Introductionmentioning

confidence: 99%

Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats

Geng

Shao

Zhang

et al. 2015

Environmental Toxicology and Pharmacology

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Please cite this article as: Geng, X., Shao, H., Zhang, Z., Ng, J.C., Peng, C.,Malathioninduced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats, Environmental Toxicology and Pharmacology (2015), http://dx.doi.org/10. 1016/j.etap.2015.01.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Malathion caused the reduction in the sperm counts and motility. The reduced body and testis weights were coupled with mild to severe degenerative changes in seminiferous tubules. We Page 3 of 32 A c c e p t e d M a n u s c r i p t 3 found malathion at 54 mg/kg increased spermatogenic apoptosis rate which was confirmed by changes in protein expression of Bax and Bcl-2. The activities of testicular enzymes including ACP, LDH and γ-GT were significantly altered with the reduced level of reproductive hormones such LH, FSH and T. These results indicate that malathion can elicit deleterious effects on reproductive system of rats. The abnormal levels of hormones and apoptotic proteins induced by malthion may play important roles.

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“…Changes observed from light microscopes showed a varied scope of occurrence and different degree of intensity according to the dose of malathion. Mammals are liked to be harmfully affected by oral, dermal and inhalation administration to malathion 23,24 . Malathion not only toxic to mammals but also toxic to different kinds of non target organisms like as fish, chicken and invertebrate.…”

Section: Figure 1: Light Microscopic Slides Of Liver Sections Of Micementioning

confidence: 99%

Untitled

2015

IJPSR

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ABSTRACT:Malathion is a widely used organophosphorous pesticide that a large number of populations are undesirably exposing themselves to severe health risk due to taking up the contaminated foods, water and vegetables containing malathion. The present study was carried out through histopathologic test to evaluate the extent of damage caused by malathion in the liver and kidney tissues of mice. Twenty five adult female albino mice were used and dispense mainly into two groups as control group and treatment group. The mice of control group were feed with poultry food without any ingredient of malathion. Each of the treatment groups (group1, group 2, group 3 and group 4, containing five animals in each group) were supplied everyday with the same type of food containing the following amounts of malathion as 65mg, 13mg, 2.6mg, and 0.52mg per 50gm (10gm food/mouse) of food, respectively. After fifteen days the animals of both groups were sacrificed and the organs of sacrificed animal were subjected to histopathological examination and then visualized under light microscope. Results demonstrated various histopathological alterations such as enlargement of the sinusoids and vacuole formations in hepatocytes and central vain, congestion of blood vessels of hepatic tissue, hemorrhage and necrosis in hepatic tissue and swelling appearances, highly degeneration and shrinkage of glomeruli, Bowman's capsules and related tubules structure, edema of renal tubules and rising of urinary space in renal tissue compared with their control. Therefore, we strongly recommend here for the ban of malathion for used as pesticide.

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Effect of short-time malathion administration on glucose homeostasis in Wistar rat

Cited by 54 publications

References 43 publications

Organophosphorus Insecticides and Glucose Homeostasis

Organophosphorus Insecticides and Glucose Homeostasis

Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats

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