Effect of short-term carvedilol therapy on salivary and plasma oxidative stress parameters and plasma glucose level in type II diabetes

Larijani, Bagher; Afshari, Mojgan; Astanehi-Asghari, Fatemeh; Mojtahedi, Alireza; Rezaie, Ali; Hossein–Nezhad, Arash; Heshmat, Ramin; Mohammadirad, Azadeh; Abdollahi, Mohammad

doi:10.1586/14750708.3.1.119

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…Further, several studies have shown that carvedilol has beneficial effects on oxidative biomarkers (it is approximately 10 times more potent than a-tocopherol) and metabolic parameters (glycemic control, insulin sensitivity, and lipid metabolism) (Dandona et al, 2007;Larijani et al, 2006;Saeidnia & Abdollahi, 2013). Such a distinctive characteristic has not been reported for other medicines of the same pharmacological class yet (Stafylas & Sarafidis, 2008).…”

Section: Introductionmentioning

confidence: 99%

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Rezvanfar

Saeedi

Mansoori

et al. 2015

Pharmaceutical Biology

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Submit your article to this journal Results: PCO rats exhibited ovarian cystogenesis which was preserved by the application of carvedilol and ANGIPARSä. In comparison with controls, decreased level of the total antioxidant power (TAP) and higher levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in serum and ovaries (2.41 ± 0.67 versus 0.72 ± 0.11; and 0.17 ± 0.04 versus 0.05 ± 0.01; 5.48 ± 1.30 versus 10.56 ± 0.77; and 7.06 ± 1.94 versus 17.98 ± 0.98; p50.05, respectively) were detected in PCO rats. Moreover, the PCO rats exhibited hyperandrogenism due to a 3.7-fold increase in serum testosterone concentration (35.04 ± 3.17 versus 131.09 ± 13.24; p50.05) along with a 2.98-fold decrease in serum progesterone (6.19 ± 0.40 versus 18.50 ± 1.03; p50.05) and 5.2-fold decrease in serum estradiol (9.30 ± 0.61 versus 48.3 ± 2.10; p50.05) when compared with those of the control group. However, similar to the control group, normal levels of OS markers and sex hormones were detected in ANGIPARSä and carvedilol co-treated PCO rats. Besides, when compared with controls, increased levels of TNF-a (770.75 ± 42.06 versus 477.14 ± 28.77; p50.05) and insulin (1.27 ± 0.10 versus 0.36 ± 0.05; p50.05) in PCO rats were significantly inhibited by carvedilol and ANGIPARSä co-treatment. Discussion and conclusion: We evidenced the beneficial effects of carvedilol and ANGIPARSä in PCO, which underpin the new alternative approach in using these kinds of medicines in female reproductive disorders.

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Section: Introductionmentioning

confidence: 99%

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Rezvanfar

Saeedi

Mansoori

et al. 2015

Pharmaceutical Biology

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“…Because of the importance of lipid and hemodynamic control most diabetic patients need different classes of drugs. For instance, the oxidative stress in diabetes can be reduced by phosphodiesterase inhibitors [12], carvedilol [13], herbal medicines [14][15][16], and pentoxiphylline [17]. Therefore it seems logical to look for new medications which may affect different pathological pathways.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy and Tolerability of Exenatide in Comparison to Placebo; A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Nikfar¹,

Abdollahi²,

Salari³

2011

J Pharm Pharm Sci

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Recent investigations in finding new drugs in the treatment of diabetes have led to the discovery of several pathological pathways involved in diabetes. Exenatide a drug with incretin mimetic activity was studied in several in vivo and in vitro as well as human studies. It has shown promising results in controlling metabolic indices in type-2 diabetes and was approved by FDA but still there is an active safety alert on it. In this study we aimed to meta-analyze all placebo-controlled clinical trials on the efficacy or tolerability of exenatide in type 2 diabetes.The literature search provided 1016 articles while only 14 articles were eligible to be included in the metaanalysis with a total of 2583 patients enrolled in the study. According to the wide variation in design of various studies, the study duration of 16 weeks and less or more and dose (5 μg bid versus 10 μg bid) were considered and analyzed.The results of this meta-analysis show that exenatide decreases fasting plasma glucose and HbA1C significantly regardless of dose and study duration. The effect of exenatide on weight reduction was more prominent at the dose of 10 μg bid regardless of the study duration, however at the dose of 5 μg bid, significant results were observed after drug administration for more than 16 weeks. Exenatide usage decreased serum triglycerides indifferent to dose and study duration while its effect on cholesterol was not prominent. Along with these impacts, exenatide changed LDL and HDL cholesterol at the lower dose. The hemodynamic effect of exenatide was observed as significant decrements in systolic and diastolic blood pressure at the higher dose. The risk of nausea, vomiting and hypoglycemia was significant and indifferent to dose while headache and nasopharyngaitis were seen more at lower dose.It is concluded that exenatide can be considered as a good hypoglycemic agent in type-2 diabetic patients with benefits on lipid profile and blood pressure with partially questionable tolerability.

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“…A number of evidence on the relationship between oxidative stress and diabetes (32)(33)(34)(42)(43)(44)(45)(46)(47) even by OP compounds (48) supports this conclusion, and calls for further research of the benefi cial effects of antioxidants (49). Our future work will focus on the balance between insulin secretion, antioxidant levels, and islet cytotoxicity.…”

Section: Figure 6 Insulin Release From Islets Of Langerhans Incubatedmentioning

confidence: 76%

Comparative Effects of Calcium Channel Blockers, Autonomic Nervous System Blockers, and Free Radical Scavengers On Diazinon-Induced Hyposecretion Of Insulin From Isolated Islets of Langerhans in Rats

Pourkhalili

Pournourmohammadi

Rahimi

et al. 2009

Archives of Industrial Hygiene and Toxicology

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Hyperglycaemia has been observed with exposure to organophosphate insecticides. This study was designed to compare the effects of calcium channel blockers, alpha-adrenergic, beta-adrenergic, and muscarinic receptor blockers, and of free radical scavengers on insulin secretion from diazinon-treated islets of Langerhans isolated from the pancreas of rats using standard collagenase digestion, separation by centrifugation, and hand-picking technique. The islets were then cultured in an incubator at 37 °C and 5 % CO 2 . In each experimental set 1 mL of 8 mmol L -1 glucose plus 125 µg mL -1 or 625 µg mL -1 of diazinon were added, except for the control group, which received 8 mmol L -1 glucose alone. The cultures were then treated with one of the following: 30 µmol L -1 atropine, 100 µmol L -1 ACh + 10 µmol L -1 neostigmine, 0.1 µmol L -1 propranolol, 2 µmol L -1 nifedipine, 50 µmol L -1 phenoxybenzamine, or 10 µmol L -1 alphatocopherol. In all experiments, diazinon signifi cantly reduced glucose-stimulated insulin secretion at both doses, showing no dose dependency, as the average inhibition for the lower dose was 62.20 % and for the higher dose 64.38 %. Acetylcholine and alpha-tocopherol restored, whereas atropine potentiated diazinoninduced hyposecretion of insulin. Alpha-, beta-and calcium channel blockers did not change diazinoninduced effects. These fi ndings suggest that diazinon affects insulin secretion mainly by disturbing the balance between free radicals and antioxidants in the islets of Langerhans and by inducing toxic stress.

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Effect of short-term carvedilol therapy on salivary and plasma oxidative stress parameters and plasma glucose level in type II diabetes

Cited by 9 publications

References 33 publications

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

Dual targeting of TNF-αand free radical toxic stress as a promising strategy to manage experimental polycystic ovary

The Efficacy and Tolerability of Exenatide in Comparison to Placebo; A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Comparative Effects of Calcium Channel Blockers, Autonomic Nervous System Blockers, and Free Radical Scavengers On Diazinon-Induced Hyposecretion Of Insulin From Isolated Islets of Langerhans in Rats

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