Effect of Short Pulsed Nonablative Infrared Laser Irradiation on Vascular Cells In Vitro and Neointimal Hyperplasia in a Rabbit Balloon Injury Model

Kipshidze, Nicholas; Nikolaychik, Victor; Muckerheidi, Michael; Keelan, Michael H.; Chekanov, Valeri; Maternowski, Michelle A.; Chawla, Paramjit; Hernández, Irina Adalid; Iyer, Sriram S.; Dangas, George; Sahota, Harry; Leon, Martin B.; Roubin, Gary S.; Moses, Jeffrey W.

doi:10.1161/hc3901.096101

Cited by 31 publications

(22 citation statements)

References 26 publications

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“…[17][18][19][20][21]29,30 In the present study, we extend these findings to show that FIR radiation exerts a potent antiinflammatory effect on vascular endothelium. We observed that FIR radiation inhibits the TNF-␣-mediated expression of the adhesion molecules VCAM-1, ICAM-1, and E-selectin, as well as the chemoattractants MCP-1 and IL-8.…”

Section: Discussionsupporting

confidence: 75%

“…In particular, the ability of nonablative infrared laser therapy to inhibit neointimal hyperplasia after percutaneous coronary angioplasty in hypercholesterolemic rabbits 29 may also occur through HO-1 because this enzyme protects against intimal thickening in various animal models of arterial injury. [12][13][14] In addition, the induction of HO-1 may contribute to the antioxidant effect of FIR.…”

Section: Discussionmentioning

confidence: 99%

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Far Infrared Therapy Inhibits Vascular Endothelial Inflammation via the Induction of Heme Oxygenase-1

Lin¹,

Liu

Peyton

et al. 2008

ATVB

116

115

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Objective-Survival of arteriovenous fistulas (AVFs) in hemodialysis patients is associated with both far infrared (FIR) therapy and length polymorphisms of the heme oxygenase-1 (HO-1) promoter. In this study, we evaluated whether there is an interaction between FIR radiation and HO-1 in regulating vascular inflammation. Methods and Results-Treatment of cultured human umbilical vein endothelial cells (ECs) with FIR radiation stimulated HO-1 protein, mRNA, and promoter activity. HO-1 induction was dependent on the activation of the antioxidant responsive element/NF-E2-related factor-2 complex, and was likely a consequence of heat stress. FIR radiation also inhibited tumor necrosis factor (TNF)-␣-mediated expression of E-selectin, vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interleukin-8, and the cytokine-mediated adhesion of monocytes to ECs. The antiinflammatory action of FIR was mimicked by bilirubin, and was reversed by the HO inhibitor, tin protoporphyrin-IX, or by the selective knockdown of HO-1. Finally, the antiinflammatory effect of FIR was also observed in patients undergoing hemodialysis. Key Words: endothelium Ⅲ far infrared therapy Ⅲ inflammation Ⅲ leukocyte adhesion A well-functioning vascular access is necessary for achieving adequate hemodialysis (HD) in patients with end stage renal failure. Approximately 17% to 25% of HD patient hospitalizations in the United States arise from vascular access complications, with an annual cost of more than 1 billion US dollars, which continues to grow. 1 Nearly 85% of vascular access failures arise from thromboses, more than 80% of which are associated with stenoses, 2 which usually presents with inadequate blood flow. 3,4 The causative factors of vascular access stenosis include small diameter of artery and vein, surgical technique, previous venipunctures, hemodynamic stress, and the presence of accessory veins. 5 Moreover, many factors leading to endothelial dysfunction, such as oxidative stress, hyperhomocysteinemia, platelet activation, and inflammation are associated with arteriovenous fistula (AVF) failure. 5 The histological features of vascular access stenosis comprise vascular inflammation, intimal hyperplasia, and excessive accumulation of extracellular matrix. 5 Despite these findings, the cause of stenoses remains unknown in a significant proportion of HD patients. This interindividual variation may relate to differences in the genetic background that may influence susceptibility to vascular inflammation and neointima formation after endothelial and smooth muscle injury. 6,7 Consistent with this notion, AVF survival was reported to be associated with specific genetic polymorphisms of transforming growth factor (TGF)-␤1 8 and methylene tetrahydrofolate reductase. 9 In addition, we recently identified a length polymorphism in the heme oxygenase-1 (HO-1) gene that is associated with patency of AVFs. 10 HO-1 catalyzes the oxidative degradation of heme into equimolar amounts of biliverdin,...

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Far Infrared Therapy Inhibits Vascular Endothelial Inflammation via the Induction of Heme Oxygenase-1

Lin¹,

Liu

Peyton

et al. 2008

ATVB

116

115

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“…61 Regarding the third mechanism, Kipshidze et al demonstrated that NIL inhibited neointimal hyperplasia. 57 Furthermore, FIR rays have been applied in treating various chronic diseases, such as hypertension, heart failure, and vascular endothelial dysfunction, which are associated with the depletion of tetrahydrobiopterin (BH4), a critical cofactor for NO synthases. 90,91 FIR therapy improves blood flow in heated surface areas, causing an increase in vascular shear stress and enhancement of the activity of GTP cyclohydrolase I, which benefits BH4 synthesis.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

Shui

Wang

Chiang

et al. 2015

Exp Biol Med (Maywood)

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Physical therapy (physiotherapy), a complementary and alternative medicine therapy, has been widely applied in diagnosing and treating various diseases and defects. Increasing evidence suggests that convenient and non-invasive far-infrared (FIR) rays, a vital type of physiotherapy, improve the health of patients with cardiovascular disease, diabetes mellitus, and chronic kidney disease. Nevertheless, the molecular mechanisms by which FIR functions remain elusive. Hence, the purpose of this study was to review and summarize the results of previous investigations and to elaborate on the molecular mechanisms of FIR therapy in various types of disease. In conclusion, FIR therapy may be closely related to the increased expression of endothelial nitric oxide synthase as well as nitric oxide production and may modulate the profiles of some circulating miRNAs; thus, it may be a beneficial complement to treatments for some chronic diseases that yields no adverse effects.

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“…A ké-szülék működése során a folyadékban keltett nagy sebességű áramlás hatására számos gázbuborék képződik, amelyek a nagyobb környező nyomás hatására kollabál-nak, ennek következtében az összecsapódó folyadék nagy energiájú lökéshullámot kelt (kavitáció), ami a baktériumok sejthártyáját megrongálva fejti ki baktericid hatását [25,26]. A lézerablatio keménylézerrel (erbiumdoped yttrium aluminium garnet laser -Er:YAG lézer) történő anyagelvétel, amelyet kiegészíthetünk lágyléze-res biostimulációval (diódalézerrel vagy neodymiumdoped yttrium aluminium granet laser -Nd:YAG lézer-rel), ami fokozza a sejtszaporodást, az osteoblastok szaporodását és differenciálódását, illetve az érképző-dést, amely növeli a csont és a nyálkahártya gyógyhajla-mát [27,28,29]. Használata a beteg számára kevésbé megterhelő, mivel lebenyképzést nem igényel, kevésbé fájdalmas, kevesebb vérzéssel jár [30].…”

Section: Esetismertetésunclassified

Sunitinib és zoledronsav által indukált állcsont-osteonecrosis

2015

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Napjainkban egyre gyakrabban találkozunk biszfoszfonátok, illetve egyéb, nem biszfoszfonát típusú antireszorptív, illetve angiogenezis-gátló gyógyszerek által indukált állcsont-osteonecrosissal. E betegkör kezelése komoly szakmai kihívást jelent a fogorvosok, dentoalveolaris és maxillofacialis sebészek számára. Kiemelkedően fontos a megelőzés, aminek alapja a gyógyszereket elrendelő szakorvosok felkészültsége, általuk a betegek fogorvosi vizsgálatra irányítása, a kezelést megelőzően fogászati gócszanálás kérése, orális higiénére nevelés, edukáció, majd a szoros fogorvosi ellenőrzés, illetve a már kialakult állcsont-osteonecrosis esetén a beteg maxillofacialis szakrendelésre irányítása. A szerzők egy sunitinib és zoledronsav kombinált terápiában részesülő állcsont-osteonecrosisban szenvedő nőbeteg konzervatív, később sebészi kezelésének nehézségeit mutatják be. A hat és tizenkét hónapos kontrollon a beteg panasz-és tünetmentesnek mutatkozott, az operált terület gyógyult. A hosszú távú sikeresség megállapításához a beteg további követésére lesz szükség.

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Effect of Short Pulsed Nonablative Infrared Laser Irradiation on Vascular Cells In Vitro and Neointimal Hyperplasia in a Rabbit Balloon Injury Model

Abstract: We conclude that nonablative infrared laser inhibited neointimal hyperplasia after PTCA in cholesterol-fed rabbits for up to 60 days.

Cited by 31 publications

References 26 publications

Far Infrared Therapy Inhibits Vascular Endothelial Inflammation via the Induction of Heme Oxygenase-1

Far Infrared Therapy Inhibits Vascular Endothelial Inflammation via the Induction of Heme Oxygenase-1

RETRACTED: Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review

Sunitinib és zoledronsav által indukált állcsont-osteonecrosis

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