Effect of short-chain alcohols as co-surfactants on pseudo-ternary phase diagrams containing lecithin

Choi, Seungkyu; Oh, Seong‐Geun; Bae, Seung Yong; Moon, Sei-Ki

doi:10.1007/bf02707128

Cited by 23 publications

(14 citation statements)

References 10 publications

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“…Formulations appeared completely dark when observed between polarising plates in crossed position because of inability of light to pass. These observations, therefore, confirmed the optical isotropy of the resulting microemulsions[828]. The globule size for all NDFX-ME formulations revealed from light-scattering experiments were in the range 65.83-121.21 nm, which is generally considered to be the globule size of microemulsion (≈10-150 nm).…”

Section: Resultssupporting

confidence: 73%

“…High solubilisation capacity and small droplet size provides better adherence to biological-membrane transporting of the drug in a controlled manner. This is most useful for treatment of acne as it improves the skin attachment and consequently enhances the accumulation of antibacterial agent in the target area[8]. Increased drug loading and high penetration through biological membrane leads to increase in the bioavailability and less inter and intra individual variability in drug's pharmacokinetics.…”

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confidence: 99%

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Design and evaluation of microemulsion gel system of nadifloxacin

2012

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Topical microemulsion systems for the antiacne agent, nadifloxacin were designed and developed to overcome the problems associated with the cutaneous delivery due to poor water solubility. The solubility of nadifloxacin in oils, surfactants and cosurfactants was evaluated to screen the components of the microemulsion. Various surfactants and cosurfactants were screened for their ability to emulsify the selected oily phase. The pseudoternary diagrams were constructed to identify the area of microemulsion existence. The influence of km (surfactant/cosurfactant) ratio on the microemulsion existence region was determined and optimum systems were designed. The systems were assessed for drug-loading efficiency and characterised for optical birefringence, pH and refractive index, robustness to dilution, globule size, drug content and thermodynamic stability. Optimised microemulsion systems were formulated into gel form and evaluated for viscosity, spreadability, drug content, ex vivo skin permeation and antibacterial activity. The maximum solubility of nadifloxacin in the microemulsion system was found to be 0.25%. The nadifloxacin microemulsions had a small and uniform globule size (67.3-121.23 nm). The stability results revealed that all formulations showed a stable globule size and the polydispersity index under stress conditions. Incorporation of nadifloxacin in microemulsion gel increased the ex vivo skin permeation and antibacterial activity when compared to marketed cream.

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Section: Resultssupporting

confidence: 73%

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confidence: 99%

Design and evaluation of microemulsion gel system of nadifloxacin

2012

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“…Choi et al . have shown that the use of different short chain alcohols, like ethanol, 1‐propanol, and 1‐butanol, were able to increase the range of composition in which the resultant emulsion containing lecithin and lidocaine is a water‐in‐oil emulsion.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation ofN,N‐diethyl‐meta‐toluamide (DEET) via miniemulsion polymerization for temperature controlled release

Gomes

Bigon

Montoro

et al. 2018

J of Applied Polymer Sci

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N,N-diethyl-meta-toluamide (DEET), an insect repellent, can be successfully encapsulated in poly(n-butyl methacrylate-comethyl methacrylate) nanospheres via direct miniemulsion polymerization. Stable and low polydisperse nanospheres with a number average diameter of 114 AE 37 nm were obtained. It is shown that DEET is an effective costabilizer and that sodium lauryl sulfate is a suitable surfactant. The nanospheres glass-transition temperature (T g ) can be tuned by adjusting the ratio between n-butyl methacrylate and methyl methacrylate in the monomer formulation. The repellent reduced the polymerization reaction rate and the copolymer molecular weight, and changed the nanoparticle morphology. The release rate of the encapsulated DEET provides repellency for over 9 h and is and more controlled when compared to the free DEET. Results show the mechanism of release is temperature dependent. At temperatures close to and lower than the polymer T g , polymer relaxation is the limiting mechanism. At higher temperatures, Fickian diffusion limits the overall release. Thus, the DEET release rate can be tuned by adjusting the copolymer T g . This ensures this material a great potential as temperature-dependent delivery system. An alternative of protection for this vulnerable population is the encapsulation and further application of DEET in fabrics, for instance. Thus, not only the DEET would not be applied directly to the skin, but its evaporation could be slowed down, increasing the repellency time of this substance.The encapsulation of substances can be achieved with a large number of techniques, like coacervation, 8 solvent evaporation, 9 and polymerization techniques 10,11 and there is also a considerable variety of carrier systems, such as liposomes, polymeric nanocapsules, micelles, etc. [12][13][14] One advantage of using polymeric systems for encapsulation is the possibility of tailoring the polymer chain, which makes them suitable for a wide range of applications, like drug delivery, 15,16 controlled release of fragrances, 17-19 and cells encapsulation. 20,21 The miniemulsion polymerization is a simple technique which allows the formation of polymer particles with controlled Additional Supporting Information may be found in the online version of this article.

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“…The DGE as co-surfactant may influence the LC formation. Choi et al (32) reported the effect of short-chain alcohols as co-surfactant on pseudo-ternary phase diagram, the LC region gradually increased in longer carbon chain of alcohol molecule. The LC regions are not observed with shorter chain alcohol (ethanol) in all regions of pseudoternary phase diagram.…”

Section: Small Angle X-ray Scatteringmentioning

confidence: 99%

Spontaneous Emulsification of Nifedipine-Loaded Self-Nanoemulsifying Drug Delivery System

et al. 2014

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ABSTRACT. Self-nanoemulsifying drug delivery system (SNEDDS) can be used to improve dissolution of poorly water-soluble drugs. The objective of this study was to prepare SNEDDS by using ternary phase diagram and investigate their spontaneous emulsifying property, dissolution of nifedipine (NDP), as well as the pharmacokinetic profile of selected SNEDDS formulation. The results showed that the composition of the SNEDDS was a great importance for the spontaneous emulsification. Based on ternary phase diagram, the region giving the SNEDDS with emulsion droplet size of less than 300 nm after diluting in aqueous medium was selected for further formulation. The small-angle X-ray scattering curves showed no sharp peak after dilution at different percentages of water, suggesting non-ordered structure. The system was found to be robust in different dilution volumes; the droplet size was in nanometer range. In vitro dissolution study showed remarkable increase in dissolution of NDP from SNEDDS formulations compared with NDP powders. The pharmacokinetic study of selected SNEDDS formulation in male Wistar rats revealed the improved maximum concentration and area under the curve. Our results proposed that the developed SNEDDS formations could be promising to improve the dissolution and oral bioavailability of NDP.

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Effect of short-chain alcohols as co-surfactants on pseudo-ternary phase diagrams containing lecithin

Cited by 23 publications

References 10 publications

Design and evaluation of microemulsion gel system of nadifloxacin

Design and evaluation of microemulsion gel system of nadifloxacin

Encapsulation ofN,N‐diethyl‐meta‐toluamide (DEET) via miniemulsion polymerization for temperature controlled release

Spontaneous Emulsification of Nifedipine-Loaded Self-Nanoemulsifying Drug Delivery System

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