Effect of Shen-Fu Injection (参附注射液) on Hemodynamics in Early Volume Resuscitation Treated Septic Shock Patients

Fan, Kai-liang; Wang, Junhui; Kong, Li; Zhang, Feihu; Hao, Hao; Zhao, Hao; Tian, Zhengyun; Yin, Ming-xin; Fang, Hua; Yang, Huihui; Liu, Yang

doi:10.1007/s11655-017-2965-z

Cited by 15 publications

(9 citation statements)

References 11 publications

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“…Secondly, SF injection has been reported to play a protective role in blood vessel spasm and microcirculation. Additionally, the components of SF, ginsenosides and aconitine, exert significantly protective effect on cardiovascular system by activating α and β receptors, thereby enhancing cardiac function as well as elevating and stabilizing blood pressure to relieve reperfusion injury [ 24 ] . However, inflammatory markers and related measurements were not investigated, and this was the limitation in our study; further studies on the abovementioned process should be focused on these.…”

Section: Discussionmentioning

confidence: 99%

Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

Yin¹,

Feng²,

Mo³

et al. 2020

Braz J Cardiovasc Surg

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Objective To investigate the effect of Shenfu (SF) injection on donor heart preservation. Methods Twelve pigs were randomly divided into SF group (n=6) and control group (n=6). After eight hours of perfusion, the differences in hemoglobin, the expression of Bcl-2 and BAX, and changes in the myocardial ultrastructure were compared to illustrate the effects of SF injection in heart preservation. Results The differences in free hemoglobin between the SF group and the control group were statistically significant ( P =0.001), and there was significant interaction of groups with times ( P =0.019), but the perfusion time may not be associated with the hemoglobin concentration ( P =0.616). According to Western blotting analysis, the expression of Bcl-2 was higher in the SF group than in the control group, while the expression of BAX was not different between the two groups. As to ultrastructural changes, both groups exhibited mitochondrial swelling and myofilament lysis, but the degree of damage in the SF group was smaller. Conclusion Our study suggests that the application of SF injection for heart preservation may protect against cardiomyocytes and erythrocytes apoptosis, and Bcl-2 protein may play a role in these physiological processes.

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Section: Discussionmentioning

confidence: 99%

Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

Yin¹,

Feng²,

Mo³

et al. 2020

Braz J Cardiovasc Surg

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“…Based on this strategy, the combination of SF with standard bundle therapy significantly improved patients' circulation, tissue perfusion, and coagulation function, as well as inflammation reactions [69]. Adding SF to conventional therapy could increase patients' mean arterial pressure (MAP), normalize the heart rate, clear serum lactate, and reduce the mortality of patients, thus reducing the occurrence of septic shock and the need for resuscitation [70,71]. Based on a systematic review and meta-analysis of randomized controlled trials, compared with standard therapy, the addition of SF showed a trend of decreasing 28-day mortality (p = 0.17) only for the septic shock patients, with 4.5 mmol/L ≤ mean arterial lactate level < 7 mmol/L and with a yang-qi deficiency (a TCM syndrome) [72].…”

Section: Shenfu Injectionmentioning

confidence: 99%

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Cheng

2021

IJMS

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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; the pathophysiology of sepsis is complex. The incidence of sepsis is steadily increasing, with worldwide mortality ranging between 30% and 50%. Current treatment approaches mainly rely on the timely and appropriate administration of antimicrobials and supportive therapies, but the search for pharmacotherapies modulating the host response has been unsuccessful. Chinese herbal medicines, i.e., Chinese patent medicines, Chinese herbal prescriptions, and single Chinese herbs, play an important role in the treatment of sepsis through multicomponent, multipathway, and multitargeting abilities and have been officially recommended for the management of COVID-19. Chinese herbal medicines have therapeutic actions promising for the treatment of sepsis; basic scientific research on these medicines is increasing. However, the material bases of most Chinese herbal medicines and their underlying mechanisms of action have not yet been fully elucidated. This review summarizes the current studies of Chinese herbal medicines used for the treatment of sepsis in terms of clinical efficacy and safety, pharmacological activity, phytochemistry, bioactive constituents, mechanisms of action, and pharmacokinetics, to provide an important foundation for clarifying the pathogenesis of sepsis and developing novel antisepsis drugs based on Chinese herbal medicines.

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“…[ 59 ] It could improve the survival rate of endotoxin shock in a rat model of acute lung injury through inhibiting the HMGB1-NF-κB pathway and preventing cytokine storm. [ 60 ] In addition, ShenFu injection (Ya'an San-jiu Pharmaceutical Co., LTD., Sichuan, China) with the dosage of 100 mL (12 hours a day, intravenous drip) also significantly improved hemodynamic indices such as cardiac index, global end diastolic volume index, mean arterial pressure, and heart rate, in early volume resuscitation treated septic shock patients.. [ 61 ] Combined metabolic pathway enrichment and topology analyses indicated that the mechanisms of ShenFu injection against coxsackievirus B3-induced acute viral myocarditis might be due to modulating the disordered homeostasis of sphingolipid metabolism, arachidonic acid metabolism, glycerophospholipid metabolism, tryptophan metabolism, and TCA cycle. [ 62 ] In vivo work showed that ShenFu injection not only inhibited NF-κB activity, but also reduced TNF-α and IL-6 expressions in systemic inflammatory response syndrome rats.…”

Section: Chinese Herbal Injections For Covid-19mentioning

confidence: 99%

Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review

Zhu

Guo

Zhang

et al. 2021

Integrative Medicine Research

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Background The outbreak of Coronavirus disease 2019 (COVID-19) has caused more than 180 million infections and 3.9 million deaths. To date, emerging clinical evidence has shown the synergetic benefits of Chinese herbal injections in treating this contagious respiratory disease. This review aims to summarize and analyze the efficacy and safety of Chinese herbal injections in the therapy of COVID-19. Methods The literature from 3 electronic databases, PubMed, CNKI, and Web of Science, were searched using the search terms “COVID-19”, “SARS-CoV-2”, “traditional Chinese medicine”, “herb”, “herbal”, and “injection”. Then the identified articles were comprehensively evaluated. Results Limited data demonstrated that Chinese herbal injections could significantly improve the clinical outcomes of COVID-19 patients, especially in combination with conventional treatment strategies. The benefits of which were mainly associated with the relief of symptoms, prevention of secondary infection, regulation of inflammation and immune function. There was also evidence showing the inhibitory effects on SARS-CoV-2 replication in vitro. Nevertheless, available real-world data suggested the increased risk of adverse event. Furthermore, the defects of existing researches and the insights for discovering novel antiviral drugs were prospectively discussed. Conclusion Evidence-based advances revealed that Chinese herbal injections such as XueBiJing injection and ShenMai injection, exerted potent effects against COVID-19. Further laboratory researches and clinical evaluation are needed to gather scientific evidence on the efficacy and safety.

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Effect of Shen-Fu Injection (参附注射液) on Hemodynamics in Early Volume Resuscitation Treated Septic Shock Patients

Abstract: SFI significantly improved hemodynamic indices such as CI, GEDI, MAP and HR in early volume resuscitation treated septic shock patients.

Cited by 15 publications

References 11 publications

Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

Effect of Shenfu Injection on Isolated Empty Beating Hearts from Miniature Pigs

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review

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