Effect of ShanZha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet

Kuo, Daih‐Huang; Yeh, Ching‐Hua; Shieh, Pochuen; Cheng, Kai‐Chun; Chen, Fu‐An; Cheng, Juei‐Tang

doi:10.1016/j.jep.2009.05.005

Cited by 50 publications

(39 citation statements)

References 33 publications

(36 reference statements)

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“…Subsequently, treatment with ST could significantly ameliorate leptin resistance. Furthermore, accompanied by the reduced circulating leptin levels, the lowered serum TG, TC, LDL-C and FFA, and increased HDL-C levels by ST were consistent with previous studies in different animal models (Memon et al, 1994;Ahmed et al,1998;Rao et al, 1999;Kuo et al, 2009;Jadeja et al, 2011). However, ST has no dosedependent effect on these.…”

Section: Discussionsupporting

confidence: 90%

Sweet tea leaves extract improves leptin resistance in diet-induced obese rats

Zhou

Huang

Liu

et al. 2013

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 90%

Sweet tea leaves extract improves leptin resistance in diet-induced obese rats

Zhou

Huang

Liu

et al. 2013

Journal of Ethnopharmacology

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“…Nowadays, medicinal plants play the key role in promoting human health and treating diseases. Traditional Chinese medicine has been reported to treat hyperlipidaemia and prevent atherosclerosis in many developing countries [3, 4]. As they are normally considered to be less toxic than synthetic agents, natural agents are increasingly purported to exert potent beneficial actions to regulate serum TC and TG levels and may thus play the role in reducing synthetic drug use for the treatment of hyperlipidemia [5].…”

Section: Introductionmentioning

confidence: 99%

Effect ofCentella asiaticaon Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models

Zhao

Shu

Zhang

et al. 2014

Oxidative Medicine and Cellular Longevity

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Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported. We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism. Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect. We observed that a fraction (CAF3) of the ethanol extract (CAE) of Centella asiatica had a cholesterol decrease of 79% and a triglyceride decrease of 95% in acute mice model, so CAF3 was further investigated in high-fat-fed hamster model. It was shown that CAF3 increased SOD and GSH-Px activities and decreased MDA level, and it also improved TC, TG, LDL-C, HDL-C, AST, and ALT levels. L-CAT and SR-BI gene expression in hamsters were increased. Taken together, our data suggest that the CAF3 fraction of Centella asiatica has antioxidant and hypolipidemic properties.

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“…Other reports have revealed that ethanol or methanol extracts of hawthorn fruit significantly increase the mRNA expression levels of PPARα 15,25,27) and that hawthorn flavonoids improve lipid metabolism by regulating the PPAR expression 28) . We examined the mRNA levels of PPARα and found that they were significantly increased in the hawthorn fruit group compared with those observed in the control group.…”

mentioning

confidence: 98%

Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice

Zhang

Geng

et al. 2014

JAT

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Aims:The protective effects of hawthorn fruit against atherosclerosis and the potential underlying mechanisms of this fruit in improving the hypolipidemic and antioxidant activities were investigated in apolipoprotein E-deficient (apoE −/− ) mice. Methods: ApoE −/− mice were divided into a control group (n = 10) and hawthorn fruit group (n = 10). The mean size of the lesions in the aortic root was assessed, and the serum glucose levels, insulin levels, lipid profiles, total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities were measured. The mRNA levels of hepatic genes related to lipid metabolism and antioxidant enzymes were examined. Results: The hawthorn fruit group mice developed significantly decreased (p＜0.05) atherosclerotic lesions. The levels of serum lipids decreased significantly (p＜0.05) and the levels of cholesterol/triglycerides, including very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), decreased in the hawthorn fruit group. The hawthorn fruit mice exhibited significantly increased T-AOC values and SOD and GSH-PX activities (p＜0.05). The hepatic fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) mRNA levels were reduced by 42% (p＜ 0.05) and 23% p＜0.05) in the mice fed the hawthorn fruit diet compared with that observed in the mice fed a standard diet. However, the hepatic hydroxymethylglutaryl CoA reductase (HMG-CoAR) mRNA levels showed no significant differences between the two groups. The mRNA expression levels of the antioxidant enzymes (SOD1, SOD2, Gpx3) were higher (p＜0.05) in the livers of the hawthorn fruit diet mice compared with those observed in the control mice. Conclusions: Hawthorn fruit exerts a protective effect against atherosclerosis in apoE −/− mice by improving the hypolipidemic and antioxidant activities.

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Effect of ShanZha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet

Cited by 50 publications

References 33 publications

Sweet tea leaves extract improves leptin resistance in diet-induced obese rats

Sweet tea leaves extract improves leptin resistance in diet-induced obese rats

Effect ofCentella asiaticaon Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models

Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice

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