Effect of SGLT2 Inhibitor on Cardiomyopathy in a Rat Model of T2DM: Possible involvement of Cardiac Aquaporins

Eltobshy, Somaia A.G.; Messiha, Refka; Metias, Emile; Sarhan, Mohamed; El-Gamal, Randa; El-Shaieb, Ahmed; Ghalwash, Mohammad

doi:10.1016/j.tice.2023.102200

Cited by 3 publications

(1 citation statement)

References 77 publications

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“…This may be explained by the fact that empagliflozin reduces the expression of aquaporins 1, 3, and 4 of cardiac endothelial cells. In mice with diabetes and cardiomyopathy, the levels of these aquaporins increased [107].…”

Section: Other Therapy Approachesmentioning

confidence: 99%

Mechanisms of Myocardial Edema Development in CVD Pathophysiology

Kiseleva,

Kirichenko,

Markina

et al. 2024

Biomedicines

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Myocardial edema is the excess accumulation of fluid in the myocardial interstitium or cardiac cells that develops due to changes in capillary permeability, loss of glycocalyx charge, imbalance in lymphatic drainage, or a combination of these factors. Today it is believed that this condition is not only a complication of cardiovascular diseases, but in itself causes aggravation of the disease and increases the risks of adverse outcomes. The study of molecular, genetic, and mechanical changes in the myocardium during edema may contribute to the development of new approaches to the diagnosis and treatment of this condition. This review was conducted to describe the main mechanisms of myocardial edema development at the molecular and cellular levels and to identify promising targets for the regulation of this condition based on articles cited in Pubmed up to January 2024.

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Section: Other Therapy Approachesmentioning

confidence: 99%