Effect of Sex on the Cardiovascular Response to Adrenaline in Humans

Schouwenberg, B.J.J.W.; Rietjens, Saskia J.; Smits, Paul; Galan, Bastiaan E. de

doi:10.1097/01.fjc.0000198519.28674.cc

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…However, this needs confirmation since spontaneous resolution of sequela aneurysms is reported in SAM [3]. Finally, the pressor effects of norepinephrine may be further intensified because of the increased sensitivity of the alpha-1 adrenergic receptors to adrenaline and by inference to the agonists causing SAM reported in premenopausal females [14]. This finding possibly accounts for the female gender preference in FMD.…”

Section: Discussionmentioning

confidence: 95%

Segmental arterial mediolysis, reparative phase: An analysis and case report showing conversion to fibromuscular dysplasia with renal infarction

Slavin¹,

Gonzalez²,

Machin³

et al. 2014

WJCD

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Segmental arterial mediolysis (SAM), an uncommon arteriopathy putatively caused by norepinephrine released by alpha-1 adrenergic agonists or some Beta-2 agonists capable of releasing norepinephrine from the peripheral sympathetic nervous system potentially can present ischemic and organ injury symptoms caused by sequelae created in its reparative phase in lieu of catastrophic hemorrhages announced in its injurious phase. The case documents this presentation-the patient presenting renal infarcts and ischemic lesions causing abdominal angina, hypertension and a nephrectomy event developing 10 years after prolonged ritodrine treatment for premature labor. This agent may have directly caused SAM or sensitized the patient to agonists causing SAM encountered at a latter date. A variety of lesions derived from injurious phase arterial injuries characterize reparative phase SAM. All were encountered in a hilar branch of the resected renal artery. These included side-by-side sequela aneurysms grossly forming a large fusiform aneurysm, granulation tissue filling adventitial medial tear spaces in which a dissecting hematomas developed, medial muscle loss centered to the outer media repaired with fibrous tissue, arterial stenosis created by reparative intimal plaques, and arterial thrombo-embolism. These lesions were mirrored in accompanying radiologic studies. The accompanying renal vein exhibited changes consistent with repair of the spastic venous angiopathy that often accompanies abdominal SAM. This angiopathy, putatively induced by Endothelin-1, suggested that this agent played a role in the genesis of the arterial lesions. Angiographic resolution of non-treated sequelae occurred in 5 months either spontaneously or due to treatment with bosentem. Conclusions: The histologic and angiographic changes demonstrate that the clinical onset of reparative SAM may be significantly delayed to produce ischemic lesions, renal infarction and in this case report, medial fibromuscular dysplasia in the hilar branch of the renal artery.

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Section: Discussionmentioning

confidence: 95%

Segmental arterial mediolysis, reparative phase: An analysis and case report showing conversion to fibromuscular dysplasia with renal infarction

Slavin¹,

Gonzalez²,

Machin³

et al. 2014

WJCD

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“…The gender-related differences might reflect to cardiac functions, responsible for the differences of sex hormones along with ageing. α-adrenergic effects are predominant in female, and β-adrenergic effects are predominant in male [7], suggesting that blood pressure may be higher sensitive for female, whereas heart rate may be higher sensitive for male. The difference might be partly resulted from the gender-related differences of trace elements.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, the gender-related alterations of physiological and pharmacological functions are produced [5,6]. In human cardiovascular responses to adrenaline, α-adrenergic effects are predominant in female, whereas β-adrenergic effects are predominant in male [7]. Cardiac functions are declined with advancing ageing [8,9].…”

Section: Introductionmentioning

confidence: 99%

Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node

Satoh

Tohno

Minami

et al. 2010

Korean J Physiol Pharmacol

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Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day-to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were − 0.178±0.081 (p＜ 0.05) and − 0.088±0.022 (p＜ 0.05) in male (n=30), and − 0.095±0.026 (p＜ 0.05) and − 0.069±0.017 (p＜ 0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p＜ 0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age-and gender-related SA nodal functions.

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“…Specifically, only those with the Met/Met genotype, which is associated with slow catecholamine metabolism, reported increased heart rate after caffeine consumption. Caffeine is known to increase catecholamines such as epinephrine and norepinephrine, 46 which are known to increase heart rate, 47 and COMT functions to inactivate these catecholamines. 24 Our findings suggest that caffeine may increase heart rate only among individuals with an impaired ability to breakdown catecholamines.…”

Section: Discussionmentioning

confidence: 99%

Catechol-O-Methyltransferase Genotype Is Associated with Self-Reported Increased Heart Rate Following Caffeine Consumption

Brathwaite

Costa

El‐Sohemy

2011

Journal of Caffeine Research

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Rationale:The mechanisms underlying the various acute effects of caffeine are not clear. Some of the physiological effects of caffeine may be mediated through increased catecholamines, which are metabolized by catechol-O-methyltransferase (COMT). A Val158Met polymorphism in COMT affects enzyme activity with Val/Val homozygotes having a 3-4-fold greater activity than Met/Met homozygotes. Objective: To determine whether the self-reported acute effects of caffeine are associated with the COMT Val158-Met polymorphism (rs4680). Methods: Subjects were men (n = 344) and women (n = 801) aged 20-29 years who were participants of the Toronto Nutrigenomics and Health Study. Acute effects were assessed by questionnaire, and caffeine intake was assessed using a semiquantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to determine if the likelihood of reporting an acute effect was associated with COMT genotype. Results: Among individuals consuming more than 200 mg/day of caffeine, COMT genotype was associated with self-reported increased heart rate. Compared to the Val/Val genotype, the adjusted OR (95% CI) of reporting increased heart rate for the Val/Met and the Met/Met genotypes was 1.43 (0.64, 3.20) and 2.98 (1.04, 8.51), respectively. Conclusions: These findings show that the Met/Met genotype, conferring slow COMT activity, is associated with self-reported increased heart rate after caffeine intake. This observation suggests that caffeine may increase heart rate in a genetic subset of the population who have an impaired ability to breakdown catecholamines such as epinephrine and norepinephrine.

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Effect of Sex on the Cardiovascular Response to Adrenaline in Humans

Cited by 10 publications

References 13 publications

Segmental arterial mediolysis, reparative phase: An analysis and case report showing conversion to fibromuscular dysplasia with renal infarction

Segmental arterial mediolysis, reparative phase: An analysis and case report showing conversion to fibromuscular dysplasia with renal infarction

Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node

Catechol-O-Methyltransferase Genotype Is Associated with Self-Reported Increased Heart Rate Following Caffeine Consumption

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