Effect of Sex Hormones on the Activities of
Hepatic Alcohol-Metabolizing Enzymes in Male Rats

Teschke, Rolf; Heymann, Karoline

doi:10.1159/000459111

Cited by 28 publications

(7 citation statements)

References 9 publications

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“…Studies have shown that hepatic ADH-specific activity is higher in female rats compared with males (4,9,51,52), but the mechanism(s) is unclear. Androgens downregulated ADH-specific activity in some studies (37,40,43), but not others (9,10), whereas estrogens increased hepatic ADH-specific activity in male rats but not females (41,57,58). Furthermore, it is unclear whether sex steroid hormones alter ADH activity directly in the liver or rather through modulation of the GH secretory pattern (9).…”

Section: Discussionmentioning

confidence: 99%

Sexual dimorphic expression of ADH in rat liver: importance of the hypothalamic-pituitary-liver axis

Simon

Fortune

Iwahashi

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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Hepatic alcohol dehydrogenase (ADH) activity is higher in female than in male rats. Although sex steroids, thyroid, and growth hormone (GH) have been shown to regulate hepatic ADH, the mechanism(s) for sexual dimorphic expression is unclear. We tested the possibility that the GH secretory pattern determined differential expression of ADH. Gonadectomized and hypophysectomized male and female rats were examined. Hepatic ADH activity was 2.1-fold greater in females. Because protein and mRNA content were also 1.7- and 2.4-fold greater, results indicated that activity differences were due to pretranslational mechanisms. Estradiol increased ADH selectively in males, and testosterone selectively decreased activity and mRNA levels in females. Effect of sex steroids on ADH was lost after hypophysectomy; infusion of GH in males increased ADH to basal female levels, supporting a role of the pituitary-liver axis. However, GH and L-thyroxine (T4) replacements alone in hypophysectomized rats did not restore dimorphic differences for either ADH activity or mRNA levels. On the other hand, T4 in combination with intermittent administration of GH reduced ADH activity and mRNA to basal male values, whereas T4 plus GH infusion replicated female levels. These results indicate that the intermittent male pattern of GH secretion combined with T4 is the principal determinant of low ADH activity in male liver.

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Section: Discussionmentioning

confidence: 99%

Sexual dimorphic expression of ADH in rat liver: importance of the hypothalamic-pituitary-liver axis

Simon

Fortune

Iwahashi

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…However, the relations between the activi ties of ADH and of ethanol metabolism in mice liver is unknown. Teschke et al reported that sex hormones such as testosterone and estradiol affect the hepatic MEOS in rats (20), and Lieber and Decarli reported that the activity of the MEOS of male rats was higher than of female rats (21). Gender-related differences were also recognized in the hepatic and renal microsomal CYP2E1-dependent metabolism of steroids (22) and xenobiotics (23) in rats and mice.…”

Section: Discussionmentioning

confidence: 99%

Gender-Related Differences in Mouse Hepatic Ethanol Metabolism.

Kishimoto

Ogishi

Ueda

et al. 2002

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Estrogens suppress MEOS, whereas testosterone restores enzyme activity in castrated animals. 5 There are important differences in alcohol-metabolizing capacity of ADH and MEOS. The microsomal ethanol-oxidizing system is an inducible enzyme, and its activity increases at higher levels of alcohol consumption, while ADH levels remain constant with alcohol use.…”

Section: Methods and Resultsmentioning

confidence: 99%

Comparison of truncal hair distribution in alcoholic liver disease and alcohol-related chronic pancreatitis

Kumar

Aggarwal

Anand

2000

The American Journal of Gastroenterology

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disease and portal hypertension. Likewise, patients with alcoholic pancreatitis had severe damage, with presence of dilated pancreatic ducts. A detailed assessment was made in each patient with respect to the amount and duration of alcohol consumption, signs of hepatic decompensation, and grading of premorbid hair distribution as described previously. 3 Briefly, grade 0 indicated a lack of hair over the trunk; grade 1, hair limited to nipple areas; grade 2, hair around nipples and middle of chest; grade 3, sparse hair over the trunk; grade 4, thick hair over the trunk; and grade 5, thick hair over the trunk and back.Eighty-six male subjects comprising 44 with ALD and 42 with alcoholic pancreatitis were investigated. The results are shown in Table 1.The duration of illness prior to presentation was shorter in patients with ALD compared with alcoholic pancreatitis. An assessment of hair distribution showed that patients with ALD had significantly less hair growth compared to patients with alcoholic pancreatitis. As expected, laboratory tests for liver disease showed greater derangement in alcoholic liver disease compared to alcoholic pancreatitis.Abstract The present study shows that scanty hair distribution over the trunk is a specific finding in patients with alcoholic liver disease (ALD), and is not seen in alcoholic pancreatitis. This observation not only provides a useful clinical marker of individuals at increased risk of developing alcohol-related liver disease, but from the pathogenetic viewpoint, it suggests that at the tissue level, the male sex hormones protect the liver against ethanol-related damage.

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Effect of Sex Hormones on the Activities of Hepatic Alcohol-Metabolizing Enzymes in Male Rats

Cited by 28 publications

References 9 publications

Sexual dimorphic expression of ADH in rat liver: importance of the hypothalamic-pituitary-liver axis

Sexual dimorphic expression of ADH in rat liver: importance of the hypothalamic-pituitary-liver axis

Gender-Related Differences in Mouse Hepatic Ethanol Metabolism.

Comparison of truncal hair distribution in alcoholic liver disease and alcohol-related chronic pancreatitis

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