Effect of Sex and Gender in Sepsis and Septic Shock: A Narrative Review

López, Ángeles; Lakbar, Inès; Léone, Marc

doi:10.1007/978-3-030-73231-8_1

Cited by 1 publication

(1 citation statement)

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“…Many studies have found that sexual dimorphism, which in uences the host immune response, is an important characteristic of sepsis [2][3][4] . Sexual dimorphism could be approached as a rst step in the personalized management of septic patients [5] . However, a large number of observational clinical studies investigating sex dependent differences in sepsis have reported con icting evidence.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic study of sex differences in sepsis

Chen

Shen

et al. 2022

Preprint

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BACKGROUND AND OBJECTIVES:There are significant differences in sepsis incidence and mortality between men and women, but the pathogenesis has remained unclear. The purpose of this study is to compare sex related expression at the transcriptional level in sepsis, and to explore potential target genes for further research. METHODS: The train dataset GSE65682 from the Gene Expression Omnibus (GEO) database was utilized for bioinformatic analysis. Four subgroups were divided according to different infection types such as CAP, HAP, AS and HC. By analyzing the differentially expressed genes (DEGs) in each subgroup between men and women, we got a list of sex related DEGs list. We further analyzed the expression levels of these genes between sepsis and healthy control groups to find the genes of interest (GOIs)with significant changes. Finally the validation dataset GSE134364 was used to verify the changes of GOIs. RESULTS: 9 genes were found by comparing the 4 subgroups DEGs of train dataset under the standard of |log2 (FC) | >0.5 and adj P.value<0.05. In the following expression analysis we got 3 GOIs, which were distributed on the Y chromosome and their expression was significantly down regulated in sepsis compared with healthy control group. These changes of GOIs were further verified by the validation set. CONCLUSIONS: The sex-related differences of sepsis in large samples were mainly manifested in sex chromosome at the transcriptomic level. The expressions of TXLNGY, USP9Y and PRKY located in the male Y chromosome were down-regulated significantly in different sepsis types, which might affect their prognosis in sepsis.

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Section: Introductionmentioning

confidence: 99%