Effect of Severe Stress Upon Thyroid Function

Williams, Robert H.; Jaffe, Herbert; Kemp, Carol A.

doi:10.1152/ajplegacy.1949.159.2.291

Cited by 53 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Soffer, Gabrilove & Jailer (1949) found a decreased 24 hr uptake of 131J in the rat following the injection of adrenaline. Williams, Jaffe & Kemp (1949) found reduced uptakes after 1 and 2 hr in rats, though the 24 hr uptake was increased. Botkin & Jensen(1952) reported a decrease in the uptake after adrenaline.…”

mentioning

confidence: 79%

The effect of exogenous and endogenous adrenaline on the uptake of radio‐iodine by the thyroid gland of the rabbit

Brown-Grant¹,

Gibson²

1956

The Journal of Physiology

View full text Add to dashboard Cite

mentioning

confidence: 79%

The effect of exogenous and endogenous adrenaline on the uptake of radio‐iodine by the thyroid gland of the rabbit

Brown-Grant¹,

Gibson²

1956

The Journal of Physiology

View full text Add to dashboard Cite

“…There is ample evidence that the RAIU is depressed in a variety of animal species during acute stress due to infection, bacterial toxins, and other related noxious stimuli (2,25,(29)(30)(31). Under these circumstances, the fraction of '31I derived from the peripheral deiodination of "3I-T4 and which ordinarily would have been trapped by the thyroid, would consequently enter the urine.…”

Section: Methodsmentioning

confidence: 99%

Alterations in thyroid iodine release and the peripheral metabolism of thyroxine during acute falciparum malaria in man

Wartofsky¹,

Martı́n²,

Earll³

1972

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T Previous studies of thyroid function during various infections have yielded conflicting results, but most have suggested an acceleration of peripheral thyroxine (Ti) turnover during the acute infectious illness. In the present studies, thyroid function was examined by a method allowing simultaneous analysis of both endogenous thyroidal release and peripheral To disposal in normal volunteers after induction of acute falciparum malaria. Subjects received iodide-'I, followed in 5-7 days by 'I-T4 intravenously. 4 days later, infection was induced by the injection of parasitized red blood cells. Bidaily measurements of serum protein-bound 'I and protein-bound 'I, and urinary 125I and 'I, together with frequent estimates of serum "'I-T4 (Murphy-Pattee) and free T4 (FT4), were made during a control period, during acute illness, and during convalescence. Alterations in the peripheral metabolism of '"'I-T4 during infection included significant decreases in the fractional disappearance rate for To [(k)], and in the clearance and daily disposal of T4, all of which returned to control values during convalescence. Total serum 'I-T4 increased late in the infected period to become greater during convalescence than either before or during infection, while FT4 did not increase significantly until convalescence. An analysis of serum 'I-T4/I-Ti and 'I-T4/ PB'I ratios confirmed these observations. The slope with time of ratios for urinary 'I/I, a reflection of thyroidal iodine release, was decreased during infection, but rebounded to control values during the convalescent period. The observed increments in serum 'I-T, concentration in the convalescent phase mnay reflect in part A preliminary report on this work appeared in abstract form in 1971. Clin. Res. 19: 384.

show abstract

“…Soffer, Volterra, Gabrilove, Pollack & Jacobs (1947) found hyperplasia of the thyroid following adrenaline injections in the dog. Soffer, Gabrilove & Jailer (1949) described a decrease in the 24 hr uptake of radio-iodine in rats following adrenaline, whereas Williams, Jaffe & Kemp (1949) found that the 24 hr uptake of 131I in rats was increased by adrenaline, although the 1 and 2 hr uptake and the serum protein-bound 1311 were decreased. Botkin & Jensen (1952) similarly report a decrease in the 131I uptake and serum protein-bound radio-iodine in rats.…”

Section: Stress and Thyroid Activitymentioning

confidence: 99%

The effect of emotional and physical stress on thyroid activity in the rabbit

Brown-Grant¹,

Harris²,

Reichlin³

1954

The Journal of Physiology

View full text Add to dashboard Cite

Many workers have shown that thyroid activity is altered by physical damage. However, there is no direct evidence that such stress affects the rate of release of thyroid hormone from the gland. As part of a study on the functional relationship between the central nervous system, anterior pituitary gland and thyroid gland a method has been devised for studying the rate of output of thyroid hormone in conscious rabbits (Brown-Grant, von Euler, Harris & Reichlin, 1954). In the experiments to be described the effects of both emotional and physical stress on the rate of release of thyroid hormone in the rabbit have been studied. METHODSThe technique used for studying thyroid activity in unanaesthetized rabbits has been described previously (Brown-Grant, von Euler, Harris & Reichlin, 1954). As in the previous work the animals were maintained on a standard diet and at a constant environmental temperature. Emotional stress has been produced by: (1) applying brief subcutaneous electric shocks (faradism) at approximately 1 min intervals. During the period of stimulation the animals were partially immobilized by placing them in small wire cages. The intensity of the stimulus was just sufficient to cause signs of fright. (2) Restraining the animals, either by confining them in a small cage, or by tying the back legs to the side of the cage with wide gauze bandages. In most experiments the two types of restraint were used alternately for periods from 24 to 72 hr, since the effect of any one procedure tended to wear off. (3) Subjecting the animals to abrupt changes in lighting, either from the normal day/night alternation to continuous darkness, or from continuous illumination to continuous darkness, or from continuous darkness to continuous illumination. All stresses were continued for at least 24 hr as it was noted that measurable changes in thyroid activity do not occur within shorter periods.Physical stress has been produced by: (1) removing 20 % of the estimated blood volume from the marginal vein of the ear on either a single occasion or on two consecutive days. (2) Subjecting the animal to laparotomy under ether anaesthesia, and (3) giving an intraperitoneal injection of 1-0 ml. turpentine (which produced no visible signs of pain or discomfort).

show abstract

Effect of Severe Stress Upon Thyroid Function

Cited by 53 publications

References 0 publications

The effect of exogenous and endogenous adrenaline on the uptake of radio‐iodine by the thyroid gland of the rabbit

The effect of exogenous and endogenous adrenaline on the uptake of radio‐iodine by the thyroid gland of the rabbit

Alterations in thyroid iodine release and the peripheral metabolism of thyroxine during acute falciparum malaria in man

The effect of emotional and physical stress on thyroid activity in the rabbit

Contact Info

Product

Resources

About