Effect of Sesamum indicum L. Seed Oil Supplementation on the Kidney Function Parameters of Hypercholesterolemic Rats

B, Ajayi Olubumi; SF, Akomolafe

doi:10.4172/2155-9600.1000306

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…An increase in the plasma creatinine level suggests kidney damage, more specifically damage to the renal filtration mechanism. 18,36 These end-products of protein metabolism, however, showed insignificant variation from the control group in this study, indicating that the risk of potential inflammatory challenge was minimal. Similarly, the tissue histology of the kidney of the extract-treated animals showed normal appearance, further confirming that the extract had no nephrotoxic effect.…”

Section: Discussionmentioning

confidence: 53%

Evaluation of the Histomorphological and Toxicological Changes in Rodents after treatment with Hydroethanolic Extract of the Secamone Afzelii Aerial Parts

Mbaka

Akala

2018

J Morphol Sci

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Objective To evaluate the histomorphological and toxicological changes in rodents after treatment with hydroethanolic extract of the Secamone afzelii aerial parts. Materials and Methods An acute toxicity study on Swiss albino mice of both sexes was performed. Administration of a single dose of 2,000 mg/kg −1 of body weight (bwt) of S. afzelii extract by gavages to 5 mice showed no mortality; hence, a 1/10th dose was used as the highest therapeutic dose. The intra-peritoneal administration produced dose-dependent mortality, with median lethal dose (LD50) being ∼ 281.8 mg/kg −1. In a subacute toxicity study, Wistar rats received daily administration of the extract in the dose range of 50 to 200 mg/kg bwt for 35 days. Its effects on histological, biochemical and hematological parameters were evaluated. Results There was an initial body weight decrease in all the treated animals in the first 7 days. Thereafter, increase in body weight was observed. The treated animals also exhibited organ weight increase when compared with the control. Statistically significant increase (p < 0.05) in aspartate aminotransferase (AST) occurred in the extract treated animals, whereas alanine aminotransferase (ALT) showed a statistically insignificant (p ≥ 0.05) increase when compared with the control. Total plasma protein (TPP) and albumin (ALB) also exhibited insignificant (p ≥ 0.05) increases, while total bilirubin (T. BIL) decreased compared with the control. Insignificant (p ≥ 0.05) changes also occurred in the plasma creatinine and urea levels in the extract treated animals when compared with the control group. The liver tissue histology showed no hepatocellular damage. However, inflammatory changes occurred in the testicular tissue, in which a quantitative decrease in spermatogenic cells was observed due to extensive cellular necrosis, leaving only the basement layer of the seminiferous tubules. Conclusion S. afzelii exhibited a high safety margin, an indication that it is safe for consumption. However, after chronic administration, it caused undesirable effect in the testes that could compromise its fertility function.

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Section: Discussionmentioning

confidence: 53%

Evaluation of the Histomorphological and Toxicological Changes in Rodents after treatment with Hydroethanolic Extract of the Secamone Afzelii Aerial Parts

Mbaka

Akala

2018

J Morphol Sci

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“…It suggested that the presence of the phenolic groups such as quercetin and naringenin in M. alba could be responsible for OH radical scavenging activity [154]. Supplementing with Sesamum indicum L. oil showed a significant reduction in ALP activities in the kidney with no corresponding increase in the serum, thus suggesting that the benniseed oil appears to attenuate the effect the hypercholesterolemic diet on the kidney [155]. In treatment of calcium oxalate urolithiasis in rats with Piper cubeba L. fruit extract, urinary crystals and histopathological derangement were improved at the doses 35 mg/kg and 60 mg/kg through significant decrease in urinary calcium after 14 days [156].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Classification of Medicinal Plants Used in the Treatment of Kidney Disease Based on Traditional Persian Medicine

Rabizadeh

Mirian

Doosti

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background and Objectives. Human beings have used natural products as one of the pharmaceutical sources to improve human health for thousands of years. Phytochemical constituents distributed in different parts of medicinal plants cause therapeutic effects on treatment of acute and chronic diseases. Over the years, traditional Persian medicine has become popular over Iran and some countries globally as a source of alternative therapies of kidney diseases and renal dysfunctions. Iranian herbal medicine consists of natural compounds with complex active ingredients that causes valuable effects. Despite performing research works on traditional Persian medicine in the treatment of kidney disorders, there is still a need to investigate on chemical components and biological molecules of medicinal plants. Methods. This review was focused on studying the various secondary metabolites in model plants of Iranian herbal medicine known as treatment of kidney diseases in traditional Persian medicine textbooks including Makhzan-ol-Advieh, The Canon of Medicine, and Taghvim al-Abdan fi Tadbir al-Ensan. Results. Secondary metabolites of 94 medical plants belonging to 42 families were reported with their scientific and family name. Conclusion. Although herbal medicines are gaining rapid popularity among people and the pharmaceutical industry, the understandings of the phytochemical and therapeutic properties of medicinal plant are important for developing effective nephroprotective medicines. Therefore, the relationship between traditional uses and biological properties should be clearly verified through further studies.

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Effect of Sesamum indicum L. Seed Oil Supplementation on the Kidney Function Parameters of Hypercholesterolemic Rats

Cited by 2 publications

References 8 publications

Evaluation of the Histomorphological and Toxicological Changes in Rodents after treatment with Hydroethanolic Extract of the Secamone Afzelii Aerial Parts

Evaluation of the Histomorphological and Toxicological Changes in Rodents after treatment with Hydroethanolic Extract of the Secamone Afzelii Aerial Parts

Phytochemical Classification of Medicinal Plants Used in the Treatment of Kidney Disease Based on Traditional Persian Medicine

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