Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis

Helli, Bijan; Mowla, Karim; Mohammadshahi, Majid; Jalali, Mohammad Taha

doi:10.1080/07315724.2015.1005198

Cited by 47 publications

(55 citation statements)

References 34 publications

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“…To calculate the sample size, we used the standard formula suggested for clinical trials by considering type one error (α) of 0.05 and type two error (β) of 0.20 (power = 80%). The sample size was calculated based on the TAC value 17 . According to this formula, 28 patients per group were needed to complete the study.…”

Section: Methodsmentioning

confidence: 99%

A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis

2020

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Aim Rheumatoid arthritis (RA), is a prevalent immune‐inflammatory disease, which is associated with disabling pain. Oxidative stress might play a role in RA pathogenesis and outcomes. According to the antioxidant properties of garlic, the current study was performed to evaluate the garlic supplement effects on some serum levels of oxidative stress biomarkers, and quality of life in patients with rheumatoid arthritis. Methods Seventy women with RA participated in this randomized, double‐blind, placebo‐controlled, parallel‐design trial. The patients were randomly divided into two groups, receiving two tablets of either 500 mg garlic or placebo daily for 8 weeks. Serum levels of total antioxidant capacity (TAC) and malondialdehyde (MDA) and quality of life were determined at baseline and end of week 8. A health assessment questionnaire (HAQ) was used to evaluate the quality of life related to health. Results Of 70 patients enrolled in the trial, 62 subjects were included in the final analysis. At the end of the study, there was a significant increase in serum levels of TAC in the garlic group as compared with the placebo group (26.58 ± 77.30 nmol of Trolox equivalent/ml vs 16.11 ± 0.92 nmol of Trolox equivalent/mL; P = .026). In addition, MDA levels were significantly decreased in the intervention group compared with the control group (−0.82 ± 1.99 nmol/mL vs 0.36 ± 2.57 nmol/mL; P = .032). Pain after activity and HAQ scores decreased in the garlic group compared with the placebo (−11.96 ± 13.43 mm vs −0.06 ± 13.41 mm; P < .001, 0.17 ± 20 vs 0.05 ± 0.15; P < .001, respectively). Conclusions The findings suggest that garlic supplementation for 8 weeks resulted in significant improvements in oxidative stress, HAQ in women with RA.

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Section: Methodsmentioning

confidence: 99%

A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis

2020

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“…In this direction, RA patients with active disease, for example, present with increased levels of ROS and diminished antioxidant potential, ultimately resulting in worse oxidative status for these individuals when compared to healthy controls [13]. Consequently, a greater degree of lipid peroxidation may be found [13,15], either in the synovial fluid or in blood samples from RA individuals [68,69]. Accordingly, serum levels of MDA, a marker of lipid peroxidation, have been described as presenting positive correlation with proinflammatory cytokines in RA [28], with reactive oxygen metabolites (ROM) in blood samples also found to be increased in patients with RA and positively correlated with disease activity [61].…”

Section: Oxidative Stress and Localmentioning

confidence: 99%

“…Several works showed different therapies as efficient complementary alternatives in disease activity control (Table 1) through antioxidant effects, with improvements observed in many disease activity parameters, such as disease activity score-28 joints (DAS-28), erythrocyte sedimentation rate (ESR), health assessment questionnaire-disability index (HAQ-DI), and visual analog scale (VAS). Among them are N-acetylcysteine, used in other diseases due to its antioxidant effect [37], synbiotic supplementation [62], pomegranate extract [66], coenzyme Q10 [70] and sesamin supplementation [68], rectal insufflation of ozone [35], saline balneotherapy [64], and laser acupuncture [69]. For all adjuvant therapies already described in the literature to date, Table 1 shows the route of administration, dose, duration, and other details from each selected study.…”

Section: Antioxidant Therapy In Rheumatoid Arthritismentioning

confidence: 99%

Oxidative Stress in Rheumatoid Arthritis: What the Future Might Hold regarding Novel Biomarkers and Add-On Therapies

Fonseca

Nunes-Souza

Goulart

et al. 2019

Oxidative Medicine and Cellular Longevity

157

121

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Numerous rheumatologic autoimmune diseases, among which rheumatoid arthritis, are chronic inflammatory diseases capable of inducing multiple cumulative articular and extra-articular damage, if not properly treated. Nevertheless, benign conditions may, similarly, exhibit arthritis as their major clinical finding, but with short-term duration instead, and evolve to spontaneous resolution in a few days to weeks, without permanent articular damage. Such distinction—self-limited arthritis with no need of immunosuppressive treatment or chronic arthritis at early stages?—represents one of the greatest challenges in clinical practice, once many metabolic, endocrine, neoplastic, granulomatous, infectious diseases and other autoimmune conditions may mimic rheumatoid arthritis. Indeed, the diagnosis of rheumatoid arthritis at early stages is a crucial step to a more effective mitigation of the disease-related damage. As a prototype of chronic inflammatory autoimmune disease, rheumatoid arthritis has been linked to oxidative stress, a condition in which the pool of reactive oxygen species increases over time, either by their augmented production, the reduction in antioxidant defenses, or the combination of both, ultimately implying compromise in the redox signaling. The exact mechanisms through which oxidative stress may contribute to the initiation and perpetuation of local (in the articular milieu) and systemic inflammation in rheumatoid arthritis, particularly at early stages, still remain to be determined. Furthermore, the role of antioxidants as therapeutic adjuvants in the control of disease activity seems to be overlooked, as a little number of short studies addressing this issue is currently found. Thus, the present review focuses on the binomial rheumatoid arthritis-oxidative stress, bringing insights into their pathophysiological relationships, as well as the implications of potential diagnostic oxidative stress biomarkers and therapeutic interventions directed to the oxidative status in patients with rheumatoid arthritis.

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“…Even in the present study we found subjects are predisposed to dyslipidemia condition is invariably. Such controversial report between the studies might be due to duration of study period or co-morbidity of the disease condition or mode of vitamin D exposure 26,27 In conclusion, study reveals that RA has a link with increased prevalence and predisposition of metabolic syndrome. Our study also revealed, among the parameters lipid profile have shown less association with the vitamin D supplementation possibly due to less exposure of sunlight or inadequate intake of vitamin D. While in vitamin D supplementation, disease activity is comparatively less in arthritis patient than in arthritic prediabetic patients.…”

Section: Discussionmentioning

confidence: 93%

Untitled

2016

IJPSR

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ABSTRACT:We planned to clarify the association between the Vitamin D supplementation and predisposition of metabolic syndrome including obesity, diabetes mellitus, hypertension and dyslipidemia in arthritic patient with pre diabetic condition and to assess prediabetes interfere in the disease progression. Retrospective observational study was conducted on 236 patients. Of these, Arthritis patients with no co-morbid condition and not supplemented with Vitamin D (47), Arthritis patients supplementing with Vitamin D (63), Arthritis patients with prediabetic condition (68), Arthritic prediabetic patients supplementing with Vitamin D (58) were recruited based on inclusion and exclusion criteria. All anthropometric parameters and clinical findings were recorded the predominance of women with RA was observed in this study and the body weight was increased substantially in entire study group irrespective of gender. A significant increase in metabolic parameters was observed in patients with arthritis who were off of Vitamin D supplementation (p<0.05). On the other hand no such significant increase was observed in vitamin D supplemented group (p>0.05. In the group of arthritic patients with prediabetes condition significant increase in metabolic parameters (p<0.01). There was no deterioration rather an improvement during the Vitamin D supplementation in prediabetic arthritic patients but lipid parameters were increased gradually in continuous visit. Predisposition of metabolic disorder was reduced with Vitamin D supplement. Prediabetes has shown positive correlation with the disease activity in RA patients. Moreover less association was observed between the lipid profile and Vitamin D status.

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Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis

Abstract: Sesamin exhibited a protective effect on cardiovascular risk factors in patients with RA. However, further investigation is suggested.

Cited by 47 publications

References 34 publications

A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis

A randomized, double‐blind, placebo‐controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis

Oxidative Stress in Rheumatoid Arthritis: What the Future Might Hold regarding Novel Biomarkers and Add-On Therapies

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