Effect of serum lipoproteins and cholesterol on an exogenous pulmonary surfactant. ESR analysis of structural changes and their relation with surfactant activity

Sarrasague, María M. Martínez; Cimato, Alejandra; Piehl, Lidia Leonor; Brites, Fernando; Facorro, Graciela

doi:10.1016/j.resp.2013.08.004

Cited by 7 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, pulmonary surfactant reduces the surface tension in order to avoid collapse of alveolar architecture at the end of expiration and to assist the work of breathing [ 26 , 27 ]. A recent study found that, of all serum components individually tested, HDL cholesterol modified the surface properties of surfactant [ 28 ]. Another possibility is that HDL cholesterol inhibits tumor necrosis factor-alpha (TNF-α) stimulated sphingosine kinase activity in endothelial cells, resulting not only in decreased sphingosine 1-phosphate production but also increased ceramide [ 12 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Association between high-density lipoprotein cholesterol level and pulmonary function in healthy Korean adolescents: the JS high school study

et al. 2017

View full text Add to dashboard Cite

BackgroundAccumulating evidence suggests that high-density lipoprotein (HDL) cholesterol is associated with pulmonary function and pulmonary disorders. The aim of this study was to evaluate the association between HDL cholesterol and pulmonary function in healthy adolescents.MethodsThis cross-sectional study was based on data collected for the JS High School study. The analysis included 644 adolescents (318 male and 326 female) aged 15–16 years old and free from asthma or chronic obstructive pulmonary disease. Fasting blood samples were collected for hematologic and biochemical assessment. Forced vital capacity volume (FVC) and forced expiratory volume in the 1 s (FEV1) were measured using dry-rolling-seal spirometry. The associations between HDL cholesterol and pulmonary function were analyzed using multiple linear regression models.ResultsAmong male adolescents, an increase of 1.0 mg/dL in HDL cholesterol was associated with 10 mL decrease in FVC (p = 0.013) and FEV1 (p = 0.013) after adjusting for age, height, weight, alcohol drinking, smoking, physical activity, systolic blood pressure, total cholesterol, triglyceride, and monthly household income. Percent predicted values of FVC (p = 0.036) and FEV1 (p = 0.017) were also inversely associated with HDL cholesterol. However, among female adolescents, HDL cholesterol level was not significantly associated with absolute or percent predictive value of FVC and FEV1.ConclusionsHigher HDL cholesterol level may be associated with decreased pulmonary function among healthy male adolescents. The sex differences observed in the association between HDL cholesterol and pulmonary function need further investigation.Electronic supplementary materialThe online version of this article (10.1186/s12890-017-0548-6) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between high-density lipoprotein cholesterol level and pulmonary function in healthy Korean adolescents: the JS high school study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Administration of exogenous surfactant has become standard therapy for infants with respiratory distress syndrome (RDS) or jaline membrane disease PROSURF has demonstrated in numerous clinical studies, using the appropriately marked product, a high distribution capacity at the alveolar level and resolution of respiratory failure. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36], Fig. No adverse effects could be found related to the administration of surfactants.…”

Section: Pulmonary Surfactant (Ps) Adjuvant Therapy In Sars-cov-2mentioning

confidence: 99%

Role of the Lung Surfactant in the Treatment of Sars-Cov-2 Infection

Riccardi¹,

Paoli²

2020

J Biotechnol Bioinforma Res

View full text Add to dashboard Cite

The spread of SARS-CoV2 has been progressing continuously for over eight months. Numerous treatments have been proposed, and many have shown efficacy and ability to control the Covid-19 syndrome in this study we propose for the first time, the use of replacement therapy with Pulmonary Surfactant (PS), in patients admitted to intensive care. Pulmonary Surfactant is widely used to treat Acute Respiratory Distress Syndrome (ARDS) in preterm babies and has shown remarkable therapeutic efficacy. Since ARDS, also known as hyaline membrane disease, has many pathogenetic and symptomatological similarities with those produced by SARS-CoV2 infection, it may be useful to associate adjuvant therapy with Pulmonary Surfactant to current therapies in use. The Surfactant that we propose in our study can act as a carrier to convey even drugs with reduced absorption and poor bioavailability, directly in the most hidden alveolar areas.

show abstract

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

Parra

Pérez‐Gil

2015

Chemistry and Physics of Lipids

236

207

View full text Add to dashboard Cite

Effect of serum lipoproteins and cholesterol on an exogenous pulmonary surfactant. ESR analysis of structural changes and their relation with surfactant activity

Cited by 7 publications

References 54 publications

Association between high-density lipoprotein cholesterol level and pulmonary function in healthy Korean adolescents: the JS high school study

Association between high-density lipoprotein cholesterol level and pulmonary function in healthy Korean adolescents: the JS high school study

Role of the Lung Surfactant in the Treatment of Sars-Cov-2 Infection

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

Contact Info

Product

Resources

About