Effect of Serum Lipid Profile on the Risk of Breast Cancer: Systematic Review and Meta-Analysis of 1,628,871 Women

Nouri, Mehran; Mohsenpour, Mohammad Ali; Katsiki, Niki; Ghobadi, Saeed; Jafari, Alireza; Faghih, Shiva; Banach, Maciej; Mazidi, Mohsen

doi:10.3390/jcm11154503

Cited by 13 publications

(12 citation statements)

References 49 publications

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“…And was no important difference between laparoscopic hepatectomy and robotic hepatectomy in the length of stay, and also in the estimated blood loss. On the other hand, complications during surgery could lead to long operations and more blood loss and may raise the hospital stay because patients need more time to recover [ 58 , 59 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic versus Robotic Hepatectomy: A Systematic Review and Meta-Analysis

Aboudou

Zhang

et al. 2022

JCM

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This study aimed to assess the surgical outcomes of robotic compared to laparoscopic hepatectomy, with a special focus on the meta-analysis method. Original studies were collected from three Chinese databases, PubMed, EMBASE, and Cochrane Library databases. Our systematic review was conducted on 682 patients with robotic liver resection, and 1101 patients were operated by laparoscopic platform. Robotic surgery has a long surgical duration (MD = 43.99, 95% CI: 23.45–64.53, p = 0.0001), while there is no significant difference in length of hospital stay (MD = 0.10, 95% CI: −0.38–0.58, p = 0.69), blood loss (MD = −20, 95% CI: −64.90–23.34, p = 0.36), the incidence of conversion (OR = 0.84, 95% CI: 0.41–1.69, p = 0.62), and tumor size (MD = 0.30, 95% CI: −0–0.60, p = 0.05); the subgroup analysis of major and minor hepatectomy on operation time is (MD = −7.08, 95% CI: −15.22–0.07, p = 0.09) and (MD = 39.87, 95% CI: −1.70–81.44, p = 0.06), respectively. However, despite the deficiencies of robotic hepatectomy in terms of extended operation time compared to laparoscopic hepatectomy, robotic hepatectomy is still effective and equivalent to laparoscopic hepatectomy in outcomes. Scientific evaluation and research on one portion of the liver may produce more efficacity and more precise results. Therefore, more clinical trials are needed to evaluate the clinical outcomes of robotic compared to laparoscopic hepatectomy.

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Section: Discussionmentioning

confidence: 99%

Laparoscopic versus Robotic Hepatectomy: A Systematic Review and Meta-Analysis

Aboudou

Zhang

et al. 2022

JCM

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“…A meta-analysis of 26 prospective studies involving 1,628,871 women showed that TG was significantly related to breast cancer development, and HDL-C was inversely related to breast cancer risk 46 . In the present study, the associations between these two biomarkers and OPS trajectory in the same direction as previous studies were observed only in premenopausal women, highlighting the importance of implementing strategies to improve lipid levels (increase HDL-C and reduce TG) before menopause.…”

Section: Discussionmentioning

confidence: 99%

Temporal relationships between BMI and obesity-related predictors of cardiometabolic and breast cancer risk in a longitudinal cohort

Xu,

Lv,

Chen

et al. 2023

Sci Rep

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Prospective inter-relationships among biomarkers were unexplored, which may provide mechanistic insights into diseases. We investigated the longitudinal associations of BMI change with trajectories of biomarkers related to cardiometabolic or breast cancer risk. A longitudinal study was conducted among 444 healthy women between 2019 to 2021. Cross‑lagged path analysis was used to examine the temporal relationships among BMI, cardiometabolic risk score (CRS), and obesity‑related proteins score (OPS) of breast cancer. Linear mixed-effect models were applied to investigate associations of time-varying BMI with biomarker-based risk score trajectories. Baseline BMI was associated with subsequent change of breast cancer predictors (P = 0.03), and baseline CRS were positively associated with OPS change (P < 0.001) but not vice versa. After fully adjustment of confounders, we found a 0.058 (95%CI = 0.009–0.107, P = 0.020) units increase of CRS and a 1.021 (95%CI = 0.041–1.995, P = 0.040) units increase of OPS as BMI increased 1 kg/m2 per year in postmenopausal women. OPS increased 0.784 (95%CI = 0.053–1.512, P = 0.035) units as CRS increased 1 unit per year. However, among premenopausal women, BMI only significantly affected CRS (β = 0.057, 95%CI = 0.007 to 0.107, P = 0.025). No significant change of OPS with time-varying CRS was found. Higher increase rates of BMI were associated with worse trajectories of biomarker-based risk of cardiometabolic and breast cancer. The longitudinal impact of CRS on OPS is unidirectional. Recommendations such as weight control for the reduction of cardiometabolic risk factors may benefit breast cancer prevention, especially in postmenopausal women.

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“…Dos Santos CR et al also disclosed that LDL-C signaling promoted BC cell survival and induced BC cell proliferation and invasion (15). In additon,the recent meta-analysis has highlighted the reversed correlation between HDL-C and BC occurrence (19). Experimental studies have also revealed that HDL-C contributes signi cantly in inhibiting the oxidative cascade of LDL-C oxidation and in alleviating in ammation stress, which may affect carcinogenesis (20,21).…”

Section: Discussionmentioning

confidence: 99%

LDL-C/HDL-C ratio:a strong metabolic risk factor of invasive breast cancer

Fan

Sun

Yin

2023

Preprint

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Objective:Our study aims to evaluate whether low density lipoprotein cholesterol/high density lipoprotein cholesterol (LDL-C/HDL-C) can act as a metabolic risk factor of invasive breast cancer (BC) in females. Methods: From January,2022 to December, 2022,505 females invasive BC and 505 age-matched controls were prospectively enrolled in our study. Data were obtained via medical records and questionnaires.We used Student’s t-test and Pearson’s χ2 test to assess the baseline characterisitcs, and binary logistic regression was utilized to clarify the metabolic risk factors of invasive BC. Finally, stratified analyses were performed according to estrogen receptor(ER) status. Results: LDL-C/HDL-C,waist circumference (WC),coronary heart disease and family history of cancer were independent risk factors of invasive BC. Among the metabolic factors,higher LDL-C/HDL-C ratio(OR,25.19,95%CI,13.15-48.25) and WC(OR,1.20,95%CI,1.15-1.24) were associa- -ted with higher BC risk(P<0.05) after adjustment for the potential confounders. Stratified analyses according to ER state also demonstrated that LDL-C/HDL-C and WC were still independent risk factors regardless of whether ER status was positive or negative(P＜0.05). Conclusions: We find that LDL-C/HDL-C ratio is a strong metabolic risk factor of invasive BC regardless of whether ER status was positive or negative.

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Effect of Serum Lipid Profile on the Risk of Breast Cancer: Systematic Review and Meta-Analysis of 1,628,871 Women

Cited by 13 publications

References 49 publications

Laparoscopic versus Robotic Hepatectomy: A Systematic Review and Meta-Analysis

Laparoscopic versus Robotic Hepatectomy: A Systematic Review and Meta-Analysis

Temporal relationships between BMI and obesity-related predictors of cardiometabolic and breast cancer risk in a longitudinal cohort

LDL-C/HDL-C ratio:a strong metabolic risk factor of invasive breast cancer

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