Effect of serum inflammatory markers on the prognosis of adult and pediatric patients with Guillain–Barré syndrome

Abstract

ObjectiveThe aim of this study was to evaluate blood neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), C-reactive protein (CRP), and albumin levels for their prognostic value in adult Guillain–Barré syndrome (GBS-A) and pediatric Guillain–Barré syndrome (GBS-P) patients.Patients and methodsWe retrospectively analyzed the medical records of 68 Guillain–Barré syndrome (GBS) patients (36 adults, 32 children) who were treated as inpatients at Harran University Faculty of Medicine, Neurology and Pediatric Neurology Departments. The pretreatment NLR, PLR, CRP, and albumin levels and Hughes scores at hospital admission, discharge, and third-month control were documented.ResultsIn GBS-A patients, the mean CRP and NLR levels at admission/discharge and third-month control were significantly higher, and the mean albumin level was significantly lower in the Hughes disability scale (HDS)≥3 group. In GBS-P group, the mean NLR level at third month was significantly higher in the HDS≥3 group. GBS-A patients had higher mean NLR, PLR, and CRP levels and lower mean albumin values than GBS-P patients. Both GBS-A and GBS-P patients had higher mean NLR, PLR, and CRP levels and lower mean albumin values than healthy controls. Only the albumin level of the GBS-A group was found to be a significant predictor of prognosis at discharge from hospital.ConclusionNLR, CRP, and albumin levels in the GBS-A group and NLR levels in the GBS-P group may be helpful in predicting the prognosis of the disease. The albumin level of GBS-A patients is an independent risk factor for prognosis at discharge from hospital.

Peripheral Blood and Cerebrospinal Fluid Cytokine Levels in Guillain Barré Syndrome: A Systematic Review and Meta-Analysis

“…Thirty of the 60 studies were excluded after reading the full text because they lacked the necessary data ( n = 7); lack of a control group ( n = 9); reported ex vivo cytokine data ( n = 4); single case reports ( n = 2), and blood or CSF cytokines were analyzed in less than three studies ( n = 8). Thus, a total of 30 studies comprising 1,302 patients with GBS and 1,073 healthy individuals were included in the meta-analysis (Sharief et al, 1993; Exley et al, 1994; Sindern et al, 1996; Creange et al, 1998; Hohnoki et al, 1998; Ossege et al, 2000; Press et al, 2001; Radhakrishnan et al, 2003, 2004; Deng et al, 2008; Nyati et al, 2010, 2011; Sainaghi et al, 2010; Li et al, 2012, 2013, 2014, 2018a,b; Liang et al, 2012; Wang et al, 2012; Han et al, 2014; Beppu et al, 2015; Du et al, 2015; Chang et al, 2016; Doncel-Perez et al, 2016; Zhang et al, 2016; Kharwar et al, 2017; Debnath et al, 2018a,b; Ethemoglu and Calik, 2018) (Flowchart see Figure 1).…”

Influence of Hyperglycaemia and CRP on the Need for Mechanical Ventilation in Guillain-Barré Syndrome

“…GBS, as a serious autoimmune disorder, may in these conditions induce a higher level of inflammation resulting in an increase in the serum C-reactive protein. CRP has already been used to predict the need for mechanical ventilation and prognosis in GBS patients with inconsistent results across studies ( 19 , 27 , 28 ). Altaweel et al found in 24 GBS patients a statistically significant positive correlation between clinical severity assessed by the Hughes disability scale and serum CRP level ( 19 ).…”

Baseline neutrophil‐lymphocyte ratio is associated with survival for infant living donor liver transplantation for biliary atresia

“…Recently, several studies have also proved the prognostic value of NLR for systematic inflammatory diseases in pediatric settings. 20,21 Interestingly, some of these pediatric patients need to accepted immunotherapy targeting on CTLA-4 and programmed death (PD)-1 receptors, which is similar to post-transplant immunotherapy. 22,23 Thus, we can assume that LT patients may share similar immune-inflammatory backgrounds with some cancer patients, and NLR could be a reliable and accessible indicator to reflect it.…”

“…Our study advances this discussion by focusing on infants with congenital BA. Recently, several studies have also proved the prognostic value of NLR for systematic inflammatory diseases in pediatric settings 20,21 . Interestingly, some of these pediatric patients need to accepted immunotherapy targeting on CTLA‐4 and programmed death (PD)‐1 receptors, which is similar to post‐transplant immunotherapy 22,23 .…”

“…PELD score for the cohort was 20(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) [Median (IQR)]; NLR of recipients was 0.9 (0.6-1.4) [Median (IQR)]. 230 (66.9%) recipients received ABO-incompatible grafts.…”