Effect of serum cholesterol levels on meta-chlorophenylpiperazine-evoked neuroendocrine responses in healthy subjects

Terao, Takeshi; Yoshimura, Reiji; Ohmori, Osamu; Takano, Tomoki; Takahashi, Norito; Iwata, Noboru; Suzuki, Takashi; Abe, Kazuhiko

doi:10.1016/s0006-3223(96)00213-2

Cited by 34 publications

(13 citation statements)

References 7 publications

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“…Thus, the degree of cortisol release to m-CPP is thought to reflect the sensitivity of the serotonergic receptors. Two studies of healthy young adults reveal serum cholesterol levels to be positively correlated with the cortisol response to m-CPP, suggesting that higher cholesterol levels are associated with a more sensitive serotonergic receptor [49,50]. However, in depressed patients, a greater sensitivity of serotonergic receptors, as evident by an elevated secretion of cortisol or prolactin after administration of d-fenfluramine, has been found to confer a good prognosis to treatment in two studies [51,52].…”

Section: Discussionmentioning

confidence: 99%

Serum Cholesterol in Treatment-Resistant Depression

et al. 2003

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Objective: Patients with major depressive disorder (MDD) may have significant differences in cholesterol levels compared with healthy controls. A previous study by our group reported that depressed patients with elevated cholesterol levels (≧200 mg/dl) were significantly more likely to be nonresponders to fluoxetine treatment than depressed patients with nonelevated cholesterol levels. However, very little is known regarding cholesterol in patients with treatment-resistant depression (TRD). The purpose of this study was to compare cholesterol levels at baseline between depressed patients with and without TRD and to test whether cholesterol levels at baseline can predict clinical response in patients with TRD treated with open-label nortriptyline (NT). Methods: Ninety-two patients with TRD entered a 6-week open trial of NT. Baseline cholesterol levels were randomly collected for 59 of these patients. Controlling for age and gender, we compared baseline cholesterol and triglyceride levels for 35 patients with TRD who did not respond to NT with 205 non-TRD patients who responded to an 8-week open trial of fluoxetine. Furthermore, with the use of logistic regression, we tested whether baseline cholesterol levels predicted clinical response to NT in the patients with TRD. Results: Patients with TRD had higher triglyceride levels at baseline compared with depressed patients without TRD. Cholesterol defined as a dichotomous variable being elevated if equal to or greater than 200 mg/dl, predicted poor response to a 6-week open trial of NT in patients with TRD. Conclusions: The results of this study confirm the relationship between hypercholesterolemia and poor outcome in the treatment of MDD for patients with TRD.

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Section: Discussionmentioning

confidence: 99%

Serum Cholesterol in Treatment-Resistant Depression

et al. 2003

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“…This suggestion is in line with Reist et al's (1996) findings that paroxetine 40 mg elicited a cortisol response that correlated with the magnitude of plasma calcium response indirectly, indicating that the response was induced via 5-HT 2A receptors. However, 5-HT 2C receptors still may be involved because the 5-HT 2C agonist (m-CPP) evokes ACTH and cortisol responses (Terao et al 1997). On the other hand, this suggestion is in contrast to the finding that cyproheptadine did not attenuate cortisol response to another SSRI, citalopram (Attenburrow et al 2001).…”

Section: Discussionmentioning

confidence: 99%

“…The former include 5-hydroxytryptophan (Meltzer et al 1984;Koyama and Meltzer 1986), l-tryptophan (Heninger et al 1984;Price et al 1991), fenfluramine (Lopez-Ibor et al 1989;O'Keane and Dinan 1991), and clomipramine (Laakman et al 1984), while the latter include metachlorophenylpiperazine (m-CPP) (Kahn and Wetzler 1991;Terao et al 1997Terao et al , 2000aTerao et al , 2000b, ipsapirone (Lesch et al 1990) and others.…”

Section: Introductionmentioning

confidence: 99%

Paroxetine as a 5-HT neuroendocrine probe

et al. 2003

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“…Serotonergic dysfunction is a well-established substrate for suicidal behavior (Mann et al, 1999;Mann et al, 2001), a relationship apparently mediated by increased aggressivity (Golomb, 1998;Oquendo et al, -In press.). Low plasma concentrations of cholesterol in turn, have been associated with low platelet 5-HT content (Delva et al, 1996), low plasma serotonin concentrations (Steegmans et al, 1996) and blunted neuroendocrine responses to MCPP (Terao et al, 1997) or fenfluramine (Muldoon et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Combined biological tests for suicide prediction

Coryell¹,

Schlesser²

2007

Psychiatry Research

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Disturbances in serotonin neuroregulation and in hypothalamic-pituitary-adrenal axis activity are both likely, and possibly independent, factors in the genesis of suicidal behavior. This analysis considers whether clinically accessible measures of these two disturbances have additive value in the estimation of risk for suicide. Seventy-four inpatients with RDC major or schizoaffective depressive disorders entered a prospective follow-up study from 1978-1981, underwent a dexamethasone suppression test (DST) and had fasting serum cholesterol levels available in the medical record. As reported earlier, patients who had had an abnormal DST result were significantly more likely to commit suicide during follow-up. Serum cholesterol concentrations did not differ by DST result and low cholesterol values were associated with subsequent suicide when age and sex were included as covariates. These results indicate that, with the use of age-appropriate thresholds, serum cholesterol concentrations may be combined with DST results to provide a clinically useful estimate of suicide risk.

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Effect of serum cholesterol levels on meta-chlorophenylpiperazine-evoked neuroendocrine responses in healthy subjects

Cited by 34 publications

References 7 publications

Serum Cholesterol in Treatment-Resistant Depression

Serum Cholesterol in Treatment-Resistant Depression

Paroxetine as a 5-HT neuroendocrine probe

Combined biological tests for suicide prediction

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