Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats

Wetzel, Wolfram; Getsova, V. M.; Jork, R.; Matthies, H

doi:10.1016/0091-3057(80)90378-0

Cited by 50 publications

(14 citation statements)

References 24 publications

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“…Post-training infusion of 5-HT in the hippocampus was reported to impair retention in a Y-maze brightness discrimination task (Wetzel et al, 1980). In agreement with these findings, Altman et al (1990) recently reported that 5-hydroxytryptaminergic deafferentiation of the hippocampus facilitated learning of a positively reinforced spatial discrimination task.…”

Section: Introductionsupporting

confidence: 72%

8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT_1A receptors

Carli

Samanin

1992

British J Pharmacology

146

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1 The effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT1A receptor agonist, on place navigation was studied by use of two spatial tasks in a water maze. 2 In the first experiment, rats treated subcutaneously with 100 and 300 (but not 30) p1gkg-1 8-OH-DPAT were impaired in their ability to locate a hidden platform. The probe test confirmed the impairment of spatial navigation but the effect (time spent in the training quadrant) was quantitatively different, depending on whether 8-OH-DPAT was administered only before each training session, only before the probe test or in both conditions. 3 In the second experiment, rats received 150pg 5,7-dihydroxytryptamine (5,7-DHT) intracerebroventricularly to destroy 5-hydroxytryptamine (5-HT-containing neurones and 24 days later were examined for choice accuracy in a two-platform spatial discrimination task.4 At 100 (but not 30)pgkg-1 8-OH-DPAT impaired rats' accuracy with no effect on latency and no errors of omission. In 5,7-DHT-treated rats, this dose had a greater effect, including errors of omission. Sham-operated rats injected with 300pugkg'-8-OH-DPAT were markedly impaired in accuracy but they had longer latencies and made more errors than controls. All the effects were increased in 5,7-DHT treated rats. 5 The results suggest that, at doses causing no apparent changes in motor behaviour or motivation, 8-OH-DPAT impairs spatial navigation by stimulating postsynaptic 5-HTlA receptors in the rat brain.

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Section: Introductionsupporting

confidence: 72%

8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT_1A receptors

Carli

Samanin

1992

British J Pharmacology

146

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“…, , 1993b have shown that the extract from Ginkgo biloba leaves (code name GK501) and its combination with the extract from ginseng roots (code name G115), corresponding to GincosanB (code name PHL-00701) possess many behavioural effects, the most essential being facilitation of learning and memory. A favourable effect of the ginkgo extract on memory process has been also reported by Winter (1991). The results of our investigations (Petkov, 1959(Petkov, , 1961(Petkov, , 1978(Petkov, , 1990Mosharrof, 1987a, 1987b) and those of other authors (Brekhman, 1957;Saito, 1990) provided convincing evidence that the extracts from ginseng roots act mainly as cognition-enhancing agents.…”

Section: Introductionsupporting

confidence: 84%

“…There are many data supporting the view that stimulation of the 5-HTergic neurotransmitter system impairs learning and memory (Essman, 1973;Wetzel et al., 1980; Ogren et af., 1981) but according to Altman and Normile (1986) this view could not be accepted without reservation. As has been mentioned already, we have studies to show that the majority of the nootropic drugs, characterized as cognition-enhancers, increase the 5-HT level in many brain structures (Petkov, 1989).…”

Section: Discussionmentioning

confidence: 98%

Participation of the serotonergic system in the memory effects of Ginkgo biloba L. and Panax ginseng C. A. Mey

Petkov

Belcheva

Konstantinova

et al. 1994

Phytotherapy Research

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The 7-day oral administration of the extracts from Ginkgo biloba (GK501) and Panax ginseng (G115) as well as their combination PHL-00701 (Gincosan@) produced changes in rat behaviour suggesting memory-enhancing effects. Single doses of agonists and antagonists of different serotonin receptor subtypes influenced the rat's capability for retention of learned behaviour and the behavioural effects of the drugs tested. GK501 decreased the density of 5-HT, receptors in the frontal cerebral cortex and hippocampus. Data concerning the effects of the drugs tested suggest the participation of the serotonergic transmitter system as an important neurochemical correlate of rat behaviour and of the memory effects of the drugs studied. This participation is modulated by the differences in the functions of the serotonin receptor subtypes.

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“…Similarly, the central serotonergic system is also reportedly involved in learning and memory. For example, intracranial or intrahippocampal administration of 5-HT impairs retention of avoidance tasks in rats (Essman 1973;Wetzel et al 1980). Moreover, 5-hydroxytryptophan (5-HTP: 5-HT precursor) and PCA (5-HT releaser) also impair avoidance learning in rats (Joyce and Hurwitz 1964;Archer et al 1981 ;Garzdn et al 198t ;Ogren 1982;Lalonde and Vikis-Freibergs 1985;Ogren and Johansson 1985).…”

Section: Discussionmentioning

confidence: 98%

Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive avoidance response in mice: comparison with acetylcholinesterase inhibitors

et al. 1993

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Mice were trained to avoid electric shocks by means of step-down type passive avoidance learning tasks, and memory retention was measured 24 h after the training session. Memory impairment (amnesia) was produced by administering either p-chloroamphetamine (PCA), a serotonin (5-HT) releaser or scopolamine (SCOP), a muscarinic cholinoceptor antagonist, 30 min prior to the training session. Benzomorphans, 5-HT2 antagonists and acetylcholinesterase (AChE) inhibitors were administered immediately after the training session. PCA- but not SCOP-induced amnesia was attenuated by the post-training administration of two benzomorphans, (+)N-allylnormetazocine ((+)SKF-10,047) and (+/- )pentazocine ((+/- )PTZ). Similarly, PCA-induced amnesia was reversed by the post-training administration of 5-HT2 antagonists, ritanserin (RIT) and mianserin (MIA), but SCOP-induced amnesia was not. However, the AChE inhibitors, tetrahydroaminoacridine (THA) and physostigmine (PHY) attenuated both PCA- and SCOP-induced amnesia when administered immediately after the training session. These results indicated that benzomorphans and 5-HT2 antagonists have antiamnestic effects in mice, as do AChE inhibitors. In addition, it is interesting that the patterns of ameliorating effect of benzomorphans were similar to those of 5-HT2 antagonists, which differ from those of AChE inhibitors.

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Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats

Cited by 50 publications

References 24 publications

8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT_1A receptors

8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT_1A receptors

Participation of the serotonergic system in the memory effects of Ginkgo biloba L. and Panax ginseng C. A. Mey

Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive avoidance response in mice: comparison with acetylcholinesterase inhibitors

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Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats

Cited by 50 publications

References 24 publications

8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT1A receptors

8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT1A receptors

Participation of the serotonergic system in the memory effects of Ginkgo biloba L. and Panax ginseng C. A. Mey

Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive avoidance response in mice: comparison with acetylcholinesterase inhibitors

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8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT_1A receptors

8‐Hydroxy‐2‐(di‐n‐propylamino)tetralin impairs spatial learning in a water maze: role of postsynaptic 5‐HT_1A receptors